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Gene Review

Aoc3  -  amine oxidase, copper containing 3

Mus musculus

Synonyms: Copper amine oxidase, Membrane primary amine oxidase, SSAO, Semicarbazide-sensitive amine oxidase, VAP-1, ...
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Disease relevance of Aoc3


Psychiatry related information on Aoc3

  • Increased SSAO-mediated deamination may contribute to protein deposition, the formation of plaques, and inflammation, and thus may be involved in the pathophysiology of chronic vascular and neurological disorders, such as diabetic complications, atherosclerosis, and Alzheimer's disease [5].

High impact information on Aoc3


Chemical compound and disease context of Aoc3


Biological context of Aoc3


Anatomical context of Aoc3


Associations of Aoc3 with chemical compounds


Regulatory relationships of Aoc3


Other interactions of Aoc3


Analytical, diagnostic and therapeutic context of Aoc3


  1. Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsis. Laudes, I.J., Guo, R.F., Riedemann, N.C., Speyer, C., Craig, R., Sarma, J.V., Ward, P.A. Am. J. Pathol. (2004) [Pubmed]
  2. Adipocytes release a soluble form of VAP-1/SSAO by a metalloprotease-dependent process and in a regulated manner. Abella, A., García-Vicente, S., Viguerie, N., Ros-Baró, A., Camps, M., Palacín, M., Zorzano, A., Marti, L. Diabetologia (2004) [Pubmed]
  3. Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet. Yu, P.H., Wang, M., Deng, Y.L., Fan, H., Shira-Bock, L. Diabetologia (2002) [Pubmed]
  4. Expression of vascular adhesion protein-1 in normal and inflamed mice lungs and normal human lungs. Singh, B., Tschernig, T., van Griensven, M., Fieguth, A., Pabst, R. Virchows Arch. (2003) [Pubmed]
  5. Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine. Gubisne-Haberle, D., Hill, W., Kazachkov, M., Richardson, J.S., Yu, P.H. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  6. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Salmi, M., Jalkanen, S. Science (1992) [Pubmed]
  7. Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1. Bonder, C.S., Norman, M.U., Swain, M.G., Zbytnuik, L.D., Yamanouchi, J., Santamaria, P., Ajuebor, M., Salmi, M., Jalkanen, S., Kubes, P. Immunity (2005) [Pubmed]
  8. Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo. Stolen, C.M., Marttila-Ichihara, F., Koskinen, K., Yegutkin, G.G., Turja, R., Bono, P., Skurnik, M., Hänninen, A., Jalkanen, S., Salmi, M. Immunity (2005) [Pubmed]
  9. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. Kuperman, D., Schofield, B., Wills-Karp, M., Grusby, M.J. J. Exp. Med. (1998) [Pubmed]
  10. Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice. Yu, P.H., Wang, M., Fan, H., Deng, Y., Gubisne-Haberle, D. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  11. Diminished lung injury with vascular adhesion molecule-1 blockade in choline-deficient ethionine diet-induced pancreatitis. Callicutt, C.S., Sabek, O., Fukatsu, K., Lundberg, A.H., Gaber, L., Wilcox, H., Kotb, M., Gaber, A.O. Surgery (2003) [Pubmed]
  12. Molecular cloning of a major mRNA species in murine 3T3 adipocyte lineage. differentiation-dependent expression, regulation, and identification as semicarbazide-sensitive amine oxidase. Moldes, M., Fève, B., Pairault, J. J. Biol. Chem. (1999) [Pubmed]
  13. Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity. Bono, P., Salmi, M., Smith, D.J., Jalkanen, S. J. Immunol. (1998) [Pubmed]
  14. Isolation, structural characterization, and chromosomal mapping of the mouse vascular adhesion protein-1 gene and promoter. Bono, P., Salmi, M., Smith, D.J., Leppänen, I., Horelli-Kuitunen, N., Palotie, A., Jalkanen, S. J. Immunol. (1998) [Pubmed]
  15. NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. Fogler, W.E., Volker, K., McCormick, K.L., Watanabe, M., Ortaldo, J.R., Wiltrout, R.H. J. Immunol. (1996) [Pubmed]
  16. Semicarbazide-sensitive amine oxidase (SSAO) gene expression in alloxan-induced diabetes in mice. Nordquist, J.E., Göktürk, C., Oreland, L. Mol. Med. (2002) [Pubmed]
  17. Origins of serum semicarbazide-sensitive amine oxidase. Stolen, C.M., Yegutkin, G.G., Kurkijärvi, R., Bono, P., Alitalo, K., Jalkanen, S. Circ. Res. (2004) [Pubmed]
  18. Vascular adhesion protein 1 (VAP-1) functions as a molecular brake during granulocyte rolling and mediates recruitment in vivo. Tohka, S., Laukkanen, M., Jalkanen, S., Salmi, M. FASEB J. (2001) [Pubmed]
  19. The release of soluble VAP-1/SSAO by 3T3-L1 adipocytes is stimulated by isoproterenol and low concentrations of TNFalpha. García-Vicente, S., Abella, A., Viguerie, N., Ros-Baró, A., Camps, M., Testar, X., Palacín, M., Zorzano, A., Marti, L. Journal of physiology and biochemistry. (2005) [Pubmed]
  20. Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis. Dopp, J.M., Breneman, S.M., Olschowka, J.A. J. Neuroimmunol. (1994) [Pubmed]
  21. Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis. Teramoto, K., Miura, S., Tsuzuki, Y., Hokari, R., Watanabe, C., Inamura, T., Ogawa, T., Hosoe, N., Nagata, H., Ishii, H., Hibi, T. Clin. Exp. Immunol. (2005) [Pubmed]
  22. Developmental platelet endothelial cell adhesion molecule expression suggests multiple roles for a vascular adhesion molecule. Redick, S.D., Bautch, V.L. Am. J. Pathol. (1999) [Pubmed]
  23. Impact of cirrhosis on the development of experimental hepatic metastases by B16F1 melanoma cells in C57BL/6 mice. Qi, K., Qiu, H., Sun, D., Minuk, G.Y., Lizardo, M., Rutherford, J., Orr, F.W. Hepatology (2004) [Pubmed]
  24. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Jaakkola, K., Nikula, T., Holopainen, R., Vähäsilta, T., Matikainen, M.T., Laukkanen, M.L., Huupponen, R., Halkola, L., Nieminen, L., Hiltunen, J., Parviainen, S., Clark, M.R., Knuuti, J., Savunen, T., Kääpä, P., Voipio-Pulkki, L.M., Jalkanen, S. Am. J. Pathol. (2000) [Pubmed]
  25. Overexpression of semicarbazide-sensitive amine oxidase in smooth muscle cells leads to an abnormal structure of the aortic elastic laminas. Göktürk, C., Nilsson, J., Nordquist, J., Kristensson, M., Svensson, K., Söderberg, C., Israelson, M., Garpenstrand, H., Sjöquist, M., Oreland, L., Forsberg-Nilsson, K. Am. J. Pathol. (2003) [Pubmed]
  26. Endogenous formaldehyde as a potential factor of vulnerability of atherosclerosis: involvement of semicarbazide-sensitive amine oxidase-mediated methylamine turnover. Yu, P.H., Deng, Y.L. Atherosclerosis (1998) [Pubmed]
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