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Gene Review

Ccr6  -  chemokine (C-C motif) receptor 6

Mus musculus

Synonyms: C-C CKR-6, C-C chemokine receptor type 6, CC-CKR-6, CCR-6, Cmkbr6, ...
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Disease relevance of Ccr6


High impact information on Ccr6


Biological context of Ccr6


Anatomical context of Ccr6


Associations of Ccr6 with chemical compounds


Physical interactions of Ccr6


Regulatory relationships of Ccr6


Other interactions of Ccr6

  • The chemokine receptor CCR6 and its ligand MIP-3alpha/CCL20 may be involved in the recruitment of these inflammatory cells [1].
  • In contrast, Ab neutralization of CCL9 in vivo resulted in significant reduction of the CD11b(+) DC number in the subepithelial dome regions of Peyer's patches of both wild type and CCR6 -/- mice [17].
  • CCR6 mRNA was not detected in any murine DC populations [18].
  • The reconstituted response was characterized by an increase in IL-5 levels, eosinophil accumulation, and serum IgE levels in recipient CCR6-/- mice [11].
  • CXCR3 and CCR6 transcripts were biased to type-1, and CCR4 transcripts increased in type-1 and type-2 populations [19].

Analytical, diagnostic and therapeutic context of Ccr6


  1. Cigarette Smoke-Induced Pulmonary Inflammation and Emphysema Are Attenuated in CCR6-Deficient Mice. Bracke, K.R., D'hulst, A.I., Maes, T., Moerloose, K.B., Demedts, I.K., Lebecque, S., Joos, G.F., Brusselle, G.G. J. Immunol. (2006) [Pubmed]
  2. Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. Lukacs, N.W., Prosser, D.M., Wiekowski, M., Lira, S.A., Cook, D.N. J. Exp. Med. (2001) [Pubmed]
  3. CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. Varona, R., Villares, R., Carramolino, L., Goya , I., Zaballos , A., Gutiérrez, J., Torres, M., Martínez-A, C., Márquez, G. J. Clin. Invest. (2001) [Pubmed]
  4. Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo. Le Borgne, M., Etchart, N., Goubier, A., Lira, S.A., Sirard, J.C., van Rooijen, N., Caux, C., Aït-Yahia, S., Vicari, A., Kaiserlian, D., Dubois, B. Immunity (2006) [Pubmed]
  5. CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Salazar-Gonzalez, R.M., Niess, J.H., Zammit, D.J., Ravindran, R., Srinivasan, A., Maxwell, J.R., Stoklasek, T., Yadav, R., Williams, I.R., Gu, X., McCormick, B.A., Pazos, M.A., Vella, A.T., Lefrancois, L., Reinecker, H.C., McSorley, S.J. Immunity (2006) [Pubmed]
  6. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Cook, D.N., Prosser, D.M., Forster, R., Zhang, J., Kuklin, N.A., Abbondanzo, S.J., Niu, X.D., Chen, S.C., Manfra, D.J., Wiekowski, M.T., Sullivan, L.M., Smith, S.R., Greenberg, H.B., Narula, S.K., Lipp, M., Lira, S.A. Immunity (2000) [Pubmed]
  7. CC chemokine ligand 20 partially controls adhesion of naive B cells to activated endothelial cells under shear stress. Meissner, A., Zilles, O., Varona, R., Jozefowski, K., Ritter, U., Marquez, G., Hallmann, R., Korner, H. Blood (2003) [Pubmed]
  8. CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses. Varona, R., Cadenas, V., Gómez, L., Martínez-A, C., Márquez, G. Blood (2005) [Pubmed]
  9. Absence of CCR6 inhibits CD4+ regulatory T-cell development and M-cell formation inside Peyer's patches. Lügering, A., Floer, M., Westphal, S., Maaser, C., Spahn, T.W., Schmidt, M.A., Domschke, W., Williams, I.R., Kucharzik, T. Am. J. Pathol. (2005) [Pubmed]
  10. CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. Osterholzer, J.J., Ames, T., Polak, T., Sonstein, J., Moore, B.B., Chensue, S.W., Toews, G.B., Curtis, J.L. J. Immunol. (2005) [Pubmed]
  11. Attenuation of allergen-induced responses in CCR6-/- mice is dependent upon altered pulmonary T lymphocyte activation. Lundy, S.K., Lira, S.A., Smit, J.J., Cook, D.N., Berlin, A.A., Lukacs, N.W. J. Immunol. (2005) [Pubmed]
  12. CCR6 has a non-redundant role in the development of inflammatory bowel disease. Varona, R., Cadenas, V., Flores, J., Martínez-A, C., Márquez, G. Eur. J. Immunol. (2003) [Pubmed]
  13. Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors. Okada, N., Masunaga, Y., Okada, Y., Iiyama, S., Mori, N., Tsuda, T., Matsubara, A., Mizuguchi, H., Hayakawa, T., Fujita, T., Yamamoto, A. Cancer Gene Ther. (2003) [Pubmed]
  14. Contact sensitizers downregulate the expression of the chemokine receptors CCR6 and CXCR4 in a skin dendritic cell line. Cruz, M.T., Gonçalo, M., Paiva, A., Morgado, J.M., Figueiredo, A., Duarte, C.B., Lopes, M.C. Arch. Dermatol. Res. (2005) [Pubmed]
  15. Astrocytes are the major intracerebral source of macrophage inflammatory protein-3alpha/CCL20 in relapsing experimental autoimmune encephalomyelitis and in vitro. Ambrosini, E., Columba-Cabezas, S., Serafini, B., Muscella, A., Aloisi, F. Glia (2003) [Pubmed]
  16. CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse. Kucharzik, T., Hudson, J.T., Waikel, R.L., Martin, W.D., Williams, I.R. Eur. J. Immunol. (2002) [Pubmed]
  17. CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells. Zhao, X., Sato, A., Dela Cruz, C.S., Linehan, M., Luegering, A., Kucharzik, T., Shirakawa, A.K., Marquez, G., Farber, J.M., Williams, I., Iwasaki, A. J. Immunol. (2003) [Pubmed]
  18. Chemotactic response toward chemokines and its regulation by transforming growth factor-beta1 of murine bone marrow hematopoietic progenitor cell-derived different subset of dendritic cells. Ogata, M., Zhang, Y., Wang, Y., Itakura, M., Zhang, Y.Y., Harada, A., Hashimoto, S., Matsushima, K. Blood (1999) [Pubmed]
  19. Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses. Chiu, B.C., Shang, X.Z., Stolberg, V.R., Komuniecki, E., Chensue, S.W. J. Leukoc. Biol. (2002) [Pubmed]
  20. CC Chemokine Receptor 6 Expression by B Lymphocytes Is Essential for the Development of Isolated Lymphoid Follicles. McDonald, K.G., McDonough, J.S., Wang, C., Kucharzik, T., Williams, I.R., Newberry, R.D. Am. J. Pathol. (2007) [Pubmed]
  21. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine. Iwasaki, A., Kelsall, B.L. J. Exp. Med. (2000) [Pubmed]
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