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Gene Review

Siglec1  -  sialic acid binding Ig-like lectin 1,...

Mus musculus

Synonyms: CD169, Cd169, SER, Sa, Sheep erythrocyte receptor, ...
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Disease relevance of Siglec1


High impact information on Siglec1

  • Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template [6].
  • In this study we present evidence that the mouse and rat sialoadhesin (originally named sheep erythrocyte receptor) on macrophages can function as a lymphocyte adhesion molecule [7].
  • An inhibitory rat mAb, SER-4, has been raised to the mouse macrophage (M phi)-restricted hemagglutinin, sheep erythrocyte receptor (SER), which binds unopsonized sheep erythrocytes through recognition of sialylated glycoconjugates [8].
  • These results therefore confirm that SER is a novel M phi-restricted receptor whose distribution and properties indicate a role in cellular interactions in hematopoietic and lymphoid tissues [8].
  • The inhibition was likely to be via steric hindrance rather than through a direct interaction with the putative sialic acid binding site of SER because F(ab')2 and Fab fragments of mAb SER-4 gave a maximum inhibition of 50-60% and 0% respectively, despite binding effectively to the SER-4 antigen (Ag) [8].

Biological context of Siglec1


Anatomical context of Siglec1


Associations of Siglec1 with chemical compounds

  • These results provide the first direct measurement of the affinity of sialoadhesin for sialosides and confirm the critical importance of the conserved arginine in interactions between sialosides and members of the siglec family of sialic acid-binding, immunoglobulin-like lectins [18].
  • BSO increased the maximum SER for SR 2508 (3 mM/fraction) from 1.2 to 1.4 in the RIF tumor, and from 1.4 to 1.8 in the MCA tumor [19].
  • The SER of 0.01 mM and 0.05 mM BSO for 24 h under the hypoxic condition is 1.21 and 1.36, respectively [20].
  • 3. Band 4 cells exhibited a 1D0 of 5.15 Gy to radiation only and 2.75 Gy to radiation plus misonidazole (SER of 1.9) [21].
  • SER values (with 95% confidence limits) were 1.28 (1.20-1.37) for 240 mg/kg SR 2508, 1.20 (1.10-1.30) for 240 mg/kg Ro 03-8799, 1.46 (1.33-1.59) for 240 mg/kg of both drugs in combination, 1.46 (1.38-1.55) for 480 mg/kg SR 2508 and 1.46 (1.31-1.62) for 480 mg/kg Ro 03-8799 [22].

Other interactions of Siglec1


Analytical, diagnostic and therapeutic context of Siglec1

  • In order to investigate its function, we generated Sn-deficient mice and confirmed that these mice are true nulls by fluorescence-activated cell sorter analysis and immunohistochemistry [15].
  • SER therefore appeared to be expressed on certain M phi populations embedded in solid tissues but was largely absent from M phi recoverable by lavage [27].
  • In the present study using mouse serum-induced thioglycollate-elicited peritoneal M phi (TPM) as a model system for SER expression, mAb SER-4 IgG2a completely blocked rosette formation at 1 microgram/ml [8].
  • In this study, the distribution of SER on macrophages within hematopoietic clusters was localized by a monoclonal antibody, SER-4, by immunofluorescence and immunoelectron microscopy [25].
  • Using flow cytometry of Sn-transfected cells and staining of lymphoid tissue sections from Sn-deficient mice, we demonstrate here that the antigen recognized by MOMA-1 is Sn [28].


  1. Recognition of sialylated meningococcal lipopolysaccharide by siglecs expressed on myeloid cells leads to enhanced bacterial uptake. Jones, C., Virji, M., Crocker, P.R. Mol. Microbiol. (2003) [Pubmed]
  2. Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0. Kobsar, I., Oetke, C., Kroner, A., Wessig, C., Crocker, P., Martini, R. Mol. Cell. Neurosci. (2006) [Pubmed]
  3. Fluorine modification of nitroazole radiosensitizers for the enhancement of sensitizing activity with lowering toxicity: a pharmacokinetic characterization. Kagiya, V.T., Nishimoto, S., Ito, T., Wang, J., Abe, M., Sasai, K. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  4. Ribonucleic acid in the immune response. Mitsuhashi, S., Saito, K., Kurashige, S., Yamaguchi, N. Mol. Cell. Biochem. (1978) [Pubmed]
  5. Protective effect of selenium on the inhibition of erythrocyte 5-aminolevulinate dehydratase activity by tin. Chiba, M., Fujimoto, N., Kikuchi, M. Toxicol. Lett. (1985) [Pubmed]
  6. Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution. May, A.P., Robinson, R.C., Vinson, M., Crocker, P.R., Jones, E.Y. Mol. Cell (1998) [Pubmed]
  7. Sialoadhesin on macrophages: its identification as a lymphocyte adhesion molecule. van den Berg, T.K., Brevé, J.J., Damoiseaux, J.G., Döpp, E.A., Kelm, S., Crocker, P.R., Dijkstra, C.D., Kraal, G. J. Exp. Med. (1992) [Pubmed]
  8. Mouse macrophage hemagglutinin (sheep erythrocyte receptor) with specificity for sialylated glycoconjugates characterized by a monoclonal antibody. Crocker, P.R., Gordon, S. J. Exp. Med. (1989) [Pubmed]
  9. Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs. Collins, B.E., Ito, H., Sawada, N., Ishida, H., Kiso, M., Schnaar, R.L. J. Biol. Chem. (1999) [Pubmed]
  10. Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice. Ip, C.W., Kroner, A., Crocker, P.R., Nave, K.A., Martini, R. Neurobiol. Dis. (2007) [Pubmed]
  11. Cellular binding mechanism on rat macrophages for sialylated glycoconjugates, inhibited by the monoclonal antibody ED3. Damoiseaux, J.G., Döpp, E.A., Dijkstra, C.D. J. Leukoc. Biol. (1991) [Pubmed]
  12. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. Higami, Y., Barger, J.L., Page, G.P., Allison, D.B., Smith, S.R., Prolla, T.A., Weindruch, R. J. Nutr. (2006) [Pubmed]
  13. Is tumour radiosensitization by misonidazole a general phenomenon? Denekamp, J., Hirst, D.G., Stewart, F.A., Terry, N.H. Br. J. Cancer (1980) [Pubmed]
  14. Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. Crocker, P.R., Kelm, S., Dubois, C., Martin, B., McWilliam, A.S., Shotton, D.M., Paulson, J.C., Gordon, S. EMBO J. (1991) [Pubmed]
  15. Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Oetke, C., Vinson, M.C., Jones, C., Crocker, P.R. Mol. Cell. Biol. (2006) [Pubmed]
  16. Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs. Brinkman-Van der Linden, E.C., Sjoberg, E.R., Juneja, L.R., Crocker, P.R., Varki, N., Varki, A. J. Biol. Chem. (2000) [Pubmed]
  17. Complex of sialoadhesin with a glycopeptide ligand. Bukrinsky, J.T., St Hilaire, P.M., Meldal, M., Crocker, P.R., Henriksen, A. Biochim. Biophys. Acta (2004) [Pubmed]
  18. Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis. Crocker, P.R., Vinson, M., Kelm, S., Drickamer, K. Biochem. J. (1999) [Pubmed]
  19. The effect of glutathione (GSH) depletion in vivo by buthionine sulfoximine (BSO) on the radiosensitization of SR 2508. Kramer, R.A., Soble, M., Howes, A.E., Montoya, V.P. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  20. The toxic effects, GSH depletion and radiosensitivity by BSO on retinoblastoma. Yi, X., Ding, L., Jin, Y., Ni, C., Wang, W. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  21. Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range. Grdina, D.J., Thames, H.D., Milas, L. Int. J. Radiat. Oncol. Biol. Phys. (1984) [Pubmed]
  22. Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system. Honess, D.J., Wasserman, T.H., Workman, P., Ward, R., Bleehen, N.M. Int. J. Radiat. Oncol. Biol. Phys. (1988) [Pubmed]
  23. Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein. Blixt, O., Collins, B.E., van den Nieuwenhof, I.M., Crocker, P.R., Paulson, J.C. J. Biol. Chem. (2003) [Pubmed]
  24. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. Chen, Y., Pikkarainen, T., Elomaa, O., Soininen, R., Kodama, T., Kraal, G., Tryggvason, K. J. Immunol. (2005) [Pubmed]
  25. Ultrastructural localization of a macrophage-restricted sialic acid binding hemagglutinin, SER, in macrophage-hematopoietic cell clusters. Crocker, P.R., Werb, Z., Gordon, S., Bainton, D.F. Blood (1990) [Pubmed]
  26. Evidence for monoclonal proliferation in prolymphocytic leukemia of T-cell orgin. A cytogenetic and Quantitative immunoautoradiographic analysis. Thiel, E., Bauchinger, M., Rodt, H., Huhn, D., Theml, H., Thierfelder, S. Blut (1977) [Pubmed]
  27. Properties and distribution of a lectin-like hemagglutinin differentially expressed by murine stromal tissue macrophages. Crocker, P.R., Gordon, S. J. Exp. Med. (1986) [Pubmed]
  28. The antigen recognized by MOMA-I is sialoadhesin. Oetke, C., Kraal, G., Crocker, P.R. Immunol. Lett. (2006) [Pubmed]
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