Disease relevance of FANCE

• The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC [1].
• However, the mutant FANCE protein fails to complement the mitomycin C hypersensitivity of the transfected cells [2].
• SAFE-Surgery, Antibiotics, Face-washing, and Environmental improvement-has incorporated sound research on elements likely to reduce trachoma, and trachomatis blindness, in endemic communities [3].
• Most strikingly, cataplexy was best differentiated from other types of muscle weakness when triggered by only three typical situations: "when hearing and telling a joke," "while laughing," or "when angry." Face or neck, rather than limbs, were also more specifically involved in clear-cut cataplexy [4].
• CONCLUSIONS: Face-specific COD crystal nucleation onto the apical surface of living renal epithelial cells followed by internalization is a heretofore unrecognized physiological event, suggesting a new mechanism to explain crystal retention within the nephron, and perhaps kidney stone formation when this process is dysregulated or overwhelmed [5].

Psychiatry related information on FANCE

• OBJECTIVE: Face recognition memory deficits in schizophrenia are attributed to frontotemporal dysfunction [6].
• METHOD: Multistage stratified clustered sampling of households in the Yoruba-speaking parts of Nigeria. Face-to-face interviews used the World Mental Health version of the Composite International Diagnostic Interview (WMH-CIDI) [7].
• To measure affect perception, we used two reliable measures of emotion recognition, the Bell-Lysaker Emotion Recognition Test and the Face Emotion Identification Test. Multiple regression analysis showed that all four attentional factors and a diagnosis of paranoid schizophrenia were significantly predictive of affect perception scores [8].
• There were no statistical significant differences between these scores before lithium therapy or after 4 and 12 months, except for immediate and delayed memory on the Person-Data Test and the 30 Face Test which showed an increased score of memory functions [9].
• The difficulty in perceiving upside-down Mooneys as faces was reflected by both lower rates of "Face" responses and delayed "Face" reaction times for upside-down relative to upright stimuli [10].

High impact information on FANCE

• Disease-associated FANCC mutants do not bind to FANCE, cannot accumulate in the nucleus and are unable to prevent chromosome breakage [11].
• DESIGN: Face-to-face survey conducted in the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions [12].
• METHODS: Face-to-face structured follow-up interviews were carried out with the subjects and separately with an additional informant, and blood samples, as well as urine specimens, were obtained for determination of state markers of heavy drinking and drug toxicology screens [13].
• Here we report the identification, by complementation cloning, of the gene mutated in FA complementation group E (FANCE) [14].
• FANCE has 10 exons and encodes a novel 536-amino acid protein with two potential nuclear localization signals [14].

Chemical compound and disease context of FANCE

• Cut-scores suggest that the SASSI-A may best be used for detecting problematic alcohol consumption using the Face Valid Alcohol Scale > or = 3 [15].
• METHODS: The authors used standard cognitive tests and a novel battery designed to reflect dysfunction in both ventral (Object, Face & Color Agnosia Screen [OFCAS]) and dorsal (complex pictures and compound stimuli) visual streams [16].

Biological context of FANCE

• DNA from three families was assigned to group FA-E by cell fusion and complementation analysis and was then used to localize the FANCE gene to chromosome 6p21-22 in an 18.2-cM region flanked by markers D6S422 and D6S1610 [17].
• FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway [18].
• Chk1-Mediated Phosphorylation of FANCE Is Required for the Fanconi Anemia/BRCA Pathway [2].
• We found that FANCE has a strong tendency to localize in the nucleus, since the addition of a nuclear export signal does not interfere with the nuclear localization of FANCE [19].
• Activation of Preexisting and Acquired Face Representations: The N250 Event-related Potential as an Index of Face Familiarity [20].

Anatomical context of FANCE

• The methods tested are those described by: 1) Gerasimov ([1971] The Face Finder; London: Hutchinson & Co.), using the distal third of the nasal bones and the nasal spine; 2) Krogman ([1962] The Human Skeleton in Forensic Medicine; Springfield: Charles C [21].
• Famous face recognition, identification and naming was assessed using the Famous Face Test. The assessment of neurofibrillary tangle (NFT) and senile plaque (SP) densities was performed in ten cortical areas in both hemispheres, and statistical analysis was made using forward stepwise logistic regression models [22].
• Using the indicator cell line BHK-HFVLTR-EGFP, we examined the effects of repeated freeze-and-thaw cycles and temperature on HFV stability by the FAE assay [23].
• Effects of FAE on intracellular cytokine profiles, T-cell apoptosis, and soluble adhesion molecules were also assessed [24].
• The Lynn Maxilla Rotator Combination Appliance and Lynn Archial Face Bow [25].

Associations of FANCE with chemical compounds

• Here, we show that, in response to DNA damage, Chk1 directly phosphorylates the FANCE subunit of the FA core complex on two conserved sites (threonine 346 and serine 374) [2].
• To release FA from food matrices, it is necessary to cleave ester cross-linking by feruloyl esterase (FAE) (hydroxycinnamoyl esterase; EC 3.1.1.73) [26].
• The metal ions Cu(2+) and Fe(3+) (at a concentration of 5 mmol liter(-1)) inhibited FAE activity by 97.25 and 94.80%, respectively [26].
• CONCLUSION: Facial-MEP with its exhalation port within the mask and the smallest mask volume demonstrated less rebreathed CO2 and a lower PDR than either the Facial-WS or Total Face masks [27].
• The tribological properties of the molecularly thin films of asymmetric ether (1,3-dimethylbutyl octyl ether, AE) and fluorinated asymmetric ether (1H,1H,2H,2H-perfluorooctyl-1,3-dimethylbutyl ether, FAE) were investigated [28].

Physical interactions of FANCE

• A Leu554Pro mutant of FANCC failed to interact with FANCE [29].

Co-localisations of FANCE

• Phosphorylated FANCE assembles in nuclear foci and colocalizes with FANCD2 [2].

Regulatory relationships of FANCE

• At present, it is poorly understood how the nuclear accumulation of FANCE is regulated and therefore we investigated the nuclear localization of this FA protein [19].

Other interactions of FANCE

• Only 2 conservative missense variants, 1 in FANCA and 1 in FANCE, were each found in a single family and were not present in 300 controls [30].
• Direct interaction between FANCE and FANCD2 was also demonstrated in the yeast 2-hybrid system [29].

Analytical, diagnostic and therapeutic context of FANCE

• IEF detected 62 patients with FAE, whereas HPLC detected 63 [31].
• Plastic safety lenses (USA Standard Practice for Occupational and Educational Eye ,nd Face Protection, approved Sept 18, 1968 by the USA Standards Institute [ANSI Z87.1-1968]) mounted in a sturdy frame (industrial or athletic) or an eye protector are necessary for squash and racquet ball [32].
• Validity and reliability studies were conducted on the Face Scale, a very brief, pictorial scale of mood which uses a sequence of 20 faces and does not require reading literacy [33].
• DESIGN: Face-to-face interviews with 18-year-olds participating in the third stage of a longitudinal study of the social patterning of health and illness [34].
• The ATICE consists of five items: Awakeness and Comprehension combined in a Consciousness domain, and Calmness, Ventilator Synchrony, and Face Relaxation combined in a Tolerance domain [35].

References