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Gene Review

ALOX5AP  -  arachidonate 5-lipoxygenase-activating...

Homo sapiens

Synonyms: Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein
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Disease relevance of ALOX5AP


Psychiatry related information on ALOX5AP


High impact information on ALOX5AP


Chemical compound and disease context of ALOX5AP

  • Although there was limited inter-study concordance of important loci, two gene variants in the leukotriene pathway (ALOX5AP and LTA4) have emerged as susceptibility factors for myocardial infarction (MI) [10].
  • Reply to Dr Nuhoğlu et al.'s Letter to the Editor re: Miroslav L. Djordjevic, Sava V. Perovic, Zoran Slavkovic and Nenad Djakovic. Longitudinal Dorsal Dartos Flap for Prevention of Fistula after a Snodgrass Hypospadias Procedure. Eur Urol 2006;50:53-57 [11].

Biological context of ALOX5AP


Anatomical context of ALOX5AP

  • To determine the functional role of polymorphisms on basal transcription, we generated ALOX5AP-promoter-luciferase constructs and transiently transfected human HeLa cells [12].
  • The small molecular inhibitor MK886 is known to block 5-lipoxygenase-activating protein ALOX5AP and shows antitumor activity in multiple human cell lines [14].
  • METHODS: We describe a technique of reconstructing the chest wall defect involving the lower costal margin and diaphragm with an Inverted Y Marlex Methylmethacrylate Sandwich Flap [15].
  • PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits [16].
  • Methodology: Thirty patients with exposed Achilles' tendon were treated with Superficial Sural Island Flap with excellent outcome [17].

Associations of ALOX5AP with chemical compounds


Regulatory relationships of ALOX5AP

  • We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase-activating protein (ALOX5AP), that associates with both diseases in Iceland [20].

Other interactions of ALOX5AP

  • OBJECTIVE: We sought to identify novel promoter polymorphisms within the FLAP (ALOX5AP) gene promoter and test the role of these and the previously identified 5-LO (ALOX5) Sp1 promoter polymorphism in asthma susceptibility [12].
  • ALOX5AP gene and the PDE4D gene in a central European population of stroke patients [21].
  • It appears reasonable to conclude that up-regulated inflammatory-gene expression (ALOX5AP, S100A8 and S100A12) may play an important role in CZ HD patients [22].
  • Polymorphisms of SG13S114T/A and SG13S89G/A in the ALOX5AP were genotyped by the polymerase chain reaction and the restriction enzyme analysis [23].

Analytical, diagnostic and therapeutic context of ALOX5AP


  1. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N.J., Gudmundsson, G., Grant, S.F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Johannsson, H., Gudmundsdottir, O., Gurney, M.E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M.L., Topol, E.J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J.R., Stefansson, K. Nat. Genet. (2004) [Pubmed]
  2. ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Kaaman, M., Rydén, M., Axelsson, T., Nordström, E., Sicard, A., Bouloumié, A., Langin, D., Arner, P., Dahlman, I. International journal of obesity (2005) (2006) [Pubmed]
  3. 5-Lipoxygenase activating protein (ALOX5AP): association with cardiovascular infarction and stroke. Ben-Asher, E., Lancet, D. Isr. Med. Assoc. J. (2004) [Pubmed]
  4. Pharmacogenomics and the drug discovery pipeline: when should it be implemented? Penny, M.A., McHale, D. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. (2005) [Pubmed]
  5. 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Manev, H., Manev, R. Med. Hypotheses (2006) [Pubmed]
  6. Acute alcohol withdrawal and free flap mandibular reconstruction outcomes. Gallivan, K.H., Reiter, D. Archives of facial plastic surgery : official publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies. (2001) [Pubmed]
  7. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D.F., Gretarsdottir, S., Magnusson, K.P., Gudmundsson, G., Hicks, A., Jonsson, T., Grant, S.F., Sainz, J., O'Brien, S.J., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Levey, A.I., Abramson, J.L., Reilly, M.P., Vaccarino, V., Wolfe, M.L., Gudnason, V., Quyyumi, A.A., Topol, E.J., Rader, D.J., Thorgeirsson, G., Gulcher, J.R., Hakonarson, H., Kong, A., Stefansson, K. Nat. Genet. (2006) [Pubmed]
  8. Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Meschia, J.F., Brott, T.G., Brown, R.D., Crook, R., Worrall, B.B., Kissela, B., Brown, W.M., Rich, S.S., Case, L.D., Evans, E.W., Hague, S., Singleton, A., Hardy, J. Ann. Neurol. (2005) [Pubmed]
  9. Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Kedda, M.A., Worsley, P., Shi, J., Phelps, S., Duffy, D., Thompson, P.J. Clin. Exp. Allergy (2005) [Pubmed]
  10. Genetic susceptibility to myocardial infarction and coronary artery disease. Topol, E.J., Smith, J., Plow, E.F., Wang, Q.K. Hum. Mol. Genet. (2006) [Pubmed]
  11. Reply to Dr Nuhoğlu et al.'s Letter to the Editor re: Miroslav L. Djordjevic, Sava V. Perovic, Zoran Slavkovic and Nenad Djakovic. Longitudinal Dorsal Dartos Flap for Prevention of Fistula after a Snodgrass Hypospadias Procedure. Eur Urol 2006;50:53-57. Djordjevic, M. Eur. Urol. (2007) [Pubmed]
  12. Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers, I., Barton, S., Rorke, S., Sawyer, J., Peng, Q., Beghé, B., Ye, S., Keith, T., Clough, J.B., Holloway, J.W., Sampson, A.P., Holgate, S.T. Clin. Exp. Allergy (2003) [Pubmed]
  13. Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. Yandava, C.N., Kennedy, B.P., Pillari, A., Duncan, A.M., Drazen, J.M. Genomics (1999) [Pubmed]
  14. Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886. Mayburd, A.L., Martlínez, A., Sackett, D., Liu, H., Shih, J., Tauler, J., Avis, I., Mulshine, J.L. Clin. Cancer Res. (2006) [Pubmed]
  15. Reconstruction of the chest wall and the diaphragm using the inverted Y Marlex methylmethacrylate sandwich flap. Rathinam, S., Venkateswaran, R., Rajesh, P.B., Collins, F.J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2004) [Pubmed]
  16. PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits. Fukiage, C., Nakajima, T., Takayama, Y., Minagawa, Y., Shearer, T.R., Azuma, M. Am. J. Ophthalmol. (2007) [Pubmed]
  17. Superficial sural artery island flap for management of exposed achilles' tendon - Surgical techniques and clinical results. Kalam, M.A., Faruquee, S.R., Karmokar, S.K., Khadka, P.B. Kathmandu University medical journal (KUMJ). (2005) [Pubmed]
  18. Development and Evaluation of a Proposed Neck Shield for the 5 Percentile Hybrid III Female Dummy. Banglmaier, R.F., Pecoraro, K.M., Feustel, J.R., Scherer, R.D., Rouhana, S.W. Stapp car crash journal (2005) [Pubmed]
  19. A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. Laaksonen, R., Katajamaa, M., P??iv??, H., Sysi-Aho, M., Saarinen, L., Junni, P., L??tjohann, D., Smet, J., Van Coster, R., Sepp??nen-Laakso, T., Lehtim??ki, T., Soini, J., Oresic, M. PLoS ONE (2006) [Pubmed]
  20. Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Helgadottir, A., Gretarsdottir, S., St Clair, D., Manolescu, A., Cheung, J., Thorleifsson, G., Pasdar, A., Grant, S.F., Whalley, L.J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J., Stefansson, K., MacLeod, M.J. Am. J. Hum. Genet. (2005) [Pubmed]
  21. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Lõhmussaar, E., Gschwendtner, A., Mueller, J.C., Org, T., Wichmann, E., Hamann, G., Meitinger, T., Dichgans, M. Stroke (2005) [Pubmed]
  22. Differential gene expression in hemodialysis patients with "cold" zheng. Chen, C.S., Lin, L.W., Hsieh, C.C., Chen, G.W., Peng, W.H., Hsieh, M.T. Am. J. Chin. Med. (2006) [Pubmed]
  23. Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Zhang, W.L., Yang, X.M., Shi, J., Sun, K., Hui, R.T. Yi Chuan Xue Bao (2006) [Pubmed]
  24. Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. Kim, S.H., Bae, J.S., Suh, C.H., Nahm, D.H., Holloway, J.W., Park, H.S. Allergy (2005) [Pubmed]
  25. Outcome of flap subluxation after laser in situ keratomileusis: results of 6 month follow-up. Recep, O.F., Cağil, N., Hasiripi, H. Journal of cataract and refractive surgery. (2000) [Pubmed]
  26. Figure-of-Eight Vertical Mattress Suture Technique for Anterior Flap Suspension to Overlying Tissues in External Dacryocystorhinostomy. Evereklioglu, C., Oner, A., Somdaş, M.A., Ketenci, I., Dogan, H., Mirza, E., Ilhan, O. Am. J. Ophthalmol. (2007) [Pubmed]
  27. Arterial coupling for microvascular free tissue transfer in head and neck reconstruction. Ross, D.A., Chow, J.Y., Shin, J., Restifo, R., Joe, J.K., Sasaki, C.T., Ariyan, S. Arch. Otolaryngol. Head Neck Surg. (2005) [Pubmed]
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