Gene Review:
ALOX5AP - arachidonate 5-lipoxygenase-activating...
Homo sapiens
Synonyms:
Arachidonate 5-lipoxygenase-activating protein, FLAP, MK-886-binding protein
Topol,
Smith,
Plow,
Wang,
Meschia,
Brott,
Brown,
Crook,
Worrall,
Kissela,
Brown,
Rich,
Case,
Evans,
Hague,
Singleton,
Hardy,
Laaksonen,
Katajamaa,
P??iv??,
Sysi-Aho,
Saarinen,
Junni,
L??tjohann,
Smet,
Van Coster,
Sepp??nen-Laakso,
Lehtim??ki,
Soini,
Oresic,
Mayburd,
Martlínez,
Sackett,
Liu,
Shih,
Tauler,
Avis,
Mulshine,
Rathinam,
Venkateswaran,
Rajesh,
Collins,
Penny,
McHale,
Ben-Asher,
Lancet,
Ross,
Chow,
Shin,
Restifo,
Joe,
Sasaki,
Ariyan,
- The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N.J., Gudmundsson, G., Grant, S.F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Johannsson, H., Gudmundsdottir, O., Gurney, M.E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M.L., Topol, E.J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J.R., Stefansson, K. Nat. Genet. (2004)
- ALOX5AP expression, but not gene haplotypes, is associated with obesity and insulin resistance. Kaaman, M., Rydén, M., Axelsson, T., Nordström, E., Sicard, A., Bouloumié, A., Langin, D., Arner, P., Dahlman, I. International journal of obesity (2005) (2006)
- 5-Lipoxygenase activating protein (ALOX5AP): association with cardiovascular infarction and stroke. Ben-Asher, E., Lancet, D. Isr. Med. Assoc. J. (2004)
- Pharmacogenomics and the drug discovery pipeline: when should it be implemented? Penny, M.A., McHale, D. American journal of pharmacogenomics : genomics-related research in drug development and clinical practice. (2005)
- 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease. Manev, H., Manev, R. Med. Hypotheses (2006)
- Acute alcohol withdrawal and free flap mandibular reconstruction outcomes. Gallivan, K.H., Reiter, D. Archives of facial plastic surgery : official publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies. (2001)
- A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D.F., Gretarsdottir, S., Magnusson, K.P., Gudmundsson, G., Hicks, A., Jonsson, T., Grant, S.F., Sainz, J., O'Brien, S.J., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Levey, A.I., Abramson, J.L., Reilly, M.P., Vaccarino, V., Wolfe, M.L., Gudnason, V., Quyyumi, A.A., Topol, E.J., Rader, D.J., Thorgeirsson, G., Gulcher, J.R., Hakonarson, H., Kong, A., Stefansson, K. Nat. Genet. (2006)
- Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke. Meschia, J.F., Brott, T.G., Brown, R.D., Crook, R., Worrall, B.B., Kissela, B., Brown, W.M., Rich, S.S., Case, L.D., Evans, E.W., Hague, S., Singleton, A., Hardy, J. Ann. Neurol. (2005)
- Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Kedda, M.A., Worsley, P., Shi, J., Phelps, S., Duffy, D., Thompson, P.J. Clin. Exp. Allergy (2005)
- Genetic susceptibility to myocardial infarction and coronary artery disease. Topol, E.J., Smith, J., Plow, E.F., Wang, Q.K. Hum. Mol. Genet. (2006)
- Reply to Dr Nuhoğlu et al.'s Letter to the Editor re: Miroslav L. Djordjevic, Sava V. Perovic, Zoran Slavkovic and Nenad Djakovic. Longitudinal Dorsal Dartos Flap for Prevention of Fistula after a Snodgrass Hypospadias Procedure. Eur Urol 2006;50:53-57. Djordjevic, M. Eur. Urol. (2007)
- Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population. Sayers, I., Barton, S., Rorke, S., Sawyer, J., Peng, Q., Beghé, B., Ye, S., Keith, T., Clough, J.B., Holloway, J.W., Sampson, A.P., Holgate, S.T. Clin. Exp. Allergy (2003)
- Cytogenetic and radiation hybrid mapping of human arachidonate 5-lipoxygenase-activating protein (ALOX5AP) to chromosome 13q12. Yandava, C.N., Kennedy, B.P., Pillari, A., Duncan, A.M., Drazen, J.M. Genomics (1999)
- Ingenuity network-assisted transcription profiling: Identification of a new pharmacologic mechanism for MK886. Mayburd, A.L., Martlínez, A., Sackett, D., Liu, H., Shih, J., Tauler, J., Avis, I., Mulshine, J.L. Clin. Cancer Res. (2006)
- Reconstruction of the chest wall and the diaphragm using the inverted Y Marlex methylmethacrylate sandwich flap. Rathinam, S., Venkateswaran, R., Rajesh, P.B., Collins, F.J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2004)
- PACAP Induces Neurite Outgrowth in Cultured Trigeminal Ganglion Cells and Recovery of Corneal Sensitivity After Flap Surgery in Rabbits. Fukiage, C., Nakajima, T., Takayama, Y., Minagawa, Y., Shearer, T.R., Azuma, M. Am. J. Ophthalmol. (2007)
- Superficial sural artery island flap for management of exposed achilles' tendon - Surgical techniques and clinical results. Kalam, M.A., Faruquee, S.R., Karmokar, S.K., Khadka, P.B. Kathmandu University medical journal (KUMJ). (2005)
- Development and Evaluation of a Proposed Neck Shield for the 5 Percentile Hybrid III Female Dummy. Banglmaier, R.F., Pecoraro, K.M., Feustel, J.R., Scherer, R.D., Rouhana, S.W. Stapp car crash journal (2005)
- A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. Laaksonen, R., Katajamaa, M., P??iv??, H., Sysi-Aho, M., Saarinen, L., Junni, P., L??tjohann, D., Smet, J., Van Coster, R., Sepp??nen-Laakso, T., Lehtim??ki, T., Soini, J., Oresic, M. PLoS ONE (2006)
- Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Helgadottir, A., Gretarsdottir, S., St Clair, D., Manolescu, A., Cheung, J., Thorleifsson, G., Pasdar, A., Grant, S.F., Whalley, L.J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J., Stefansson, K., MacLeod, M.J. Am. J. Hum. Genet. (2005)
- ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Lõhmussaar, E., Gschwendtner, A., Mueller, J.C., Org, T., Wichmann, E., Hamann, G., Meitinger, T., Dichgans, M. Stroke (2005)
- Differential gene expression in hemodialysis patients with "cold" zheng. Chen, C.S., Lin, L.W., Hsieh, C.C., Chen, G.W., Peng, W.H., Hsieh, M.T. Am. J. Chin. Med. (2006)
- Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Zhang, W.L., Yang, X.M., Shi, J., Sun, K., Hui, R.T. Yi Chuan Xue Bao (2006)
- Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma: a positive association with airway hyperresponsiveness. Kim, S.H., Bae, J.S., Suh, C.H., Nahm, D.H., Holloway, J.W., Park, H.S. Allergy (2005)
- Outcome of flap subluxation after laser in situ keratomileusis: results of 6 month follow-up. Recep, O.F., Cağil, N., Hasiripi, H. Journal of cataract and refractive surgery. (2000)
- Figure-of-Eight Vertical Mattress Suture Technique for Anterior Flap Suspension to Overlying Tissues in External Dacryocystorhinostomy. Evereklioglu, C., Oner, A., Somdaş, M.A., Ketenci, I., Dogan, H., Mirza, E., Ilhan, O. Am. J. Ophthalmol. (2007)
- Arterial coupling for microvascular free tissue transfer in head and neck reconstruction. Ross, D.A., Chow, J.Y., Shin, J., Restifo, R., Joe, J.K., Sasaki, C.T., Ariyan, S. Arch. Otolaryngol. Head Neck Surg. (2005)