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Gene Review

Hsd11b2  -  hydroxysteroid 11-beta dehydrogenase 2

Rattus norvegicus

Synonyms: 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, Hsd11k, ...
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Disease relevance of Hsd11b2


High impact information on Hsd11b2

  • To study the role of 11 beta-HSD2 in acid-base homeostasis, 11 beta-HSD2 activity was measured in rat IMCD-enriched cell suspensions [4].
  • Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells [5].
  • In most nonepithelial tissues, including cardiomyocytes, 11 beta HSD2 is expressed at minimal levels; in these tissues physiologic glucocorticoids act as MR antagonists, with the basis for this tissue selectivity currently unknown [6].
  • Rat 11 beta HSD2 complementary DNA was cloned downstream of a 2.3- and 3.6-kb alpha 1(I)-collagen (Col1a1) promoter fragment to produce the expression plasmids Col2.3-HSD2 and Col3.6-HSD2, respectively, which were transiently and/or stably transfected in osteoblastic ROS 17/2.8 and MC3T3-E1 cells [7].
  • Transfection of 11 beta HSD2 led to higher rates of conversion of [(3)H]corticosterone to [(3)H]dehydrocorticosterone and reduced glucocorticoid-dependent regulation of a mouse mammary tumor virus promoter-reporter construct, cell growth, and messenger RNA markers compared with transfection of a control vector [7].

Chemical compound and disease context of Hsd11b2


Biological context of Hsd11b2


Anatomical context of Hsd11b2


Associations of Hsd11b2 with chemical compounds


Co-localisations of Hsd11b2


Other interactions of Hsd11b2


Analytical, diagnostic and therapeutic context of Hsd11b2


  1. LLC-PK1 cells model 11 beta-hydroxysteroid dehydrogenase type 2 regulation of glucocorticoid access to renal mineralocorticoid receptors. Leckie, C., Chapman, K.E., Edwards, C.R., Seckl, J.R. Endocrinology (1995) [Pubmed]
  2. 11 beta-Hydroxysteroid dehydrogenase antisense affects vascular contractile response and glucocorticoid metabolism. Souness, G.W., Brem, A.S., Morris, D.J. Steroids (2002) [Pubmed]
  3. Glucocorticoids and 11 beta-hydroxysteroid dehydrogenase type 2 gene expression in the aging kidney. Audigé, A., Dick, B., Frey, B.M., Frey, F.J., Corman, B., Vogt, B. Eur. J. Clin. Invest. (2002) [Pubmed]
  4. Inhibition of IMCD 11 beta-hydroxysteroid dehydrogenase type 2 by low pH and acute acid loading. Nolan, P.J., Knepper, M.A., Packer, R.K. J. Am. Soc. Nephrol. (1997) [Pubmed]
  5. Expression and functional state of the corticosteroid receptors and 11 beta-hydroxysteroid dehydrogenase type 2 in Schwann cells. Groyer, G., Eychenne, B., Girard, C., Rajkowski, K., Schumacher, M., Cadepond, F. Endocrinology (2006) [Pubmed]
  6. Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation. Young, M.J., Moussa, L., Dilley, R., Funder, J.W. Endocrinology (2003) [Pubmed]
  7. Cloning and in vitro characterization of alpha 1(I)-collagen 11 beta-hydroxysteroid dehydrogenase type 2 transgenes as models for osteoblast-selective inactivation of natural glucocorticoids. Woitge, H., Harrison, J., Ivkosic, A., Krozowski, Z., Kream, B. Endocrinology (2001) [Pubmed]
  8. Endogenous 11 beta-hydroxysteroid dehydrogenase inhibitors and their role in glucocorticoid Na+ retention and hypertension. Morris, D.J., Souness, G.W. Endocr. Res. (1996) [Pubmed]
  9. 11-beta Hydroxysteroid dehydrogenase type 2 expression in white adipose tissue is strongly correlated with adiposity. Milagro, F.I., Campión, J., Martínez, J.A. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  10. Myometrial expression of 11 beta-hydroxysteroid dehydrogenase type 2 in rat pregnancy. Burton, P.J., Waddell, B.J. J. Endocrinol. (2002) [Pubmed]
  11. 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Robson, A.C., Leckie, C.M., Seckl, J.R., Holmes, M.C. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  12. Gene expression in rat leydig cells during development from the progenitor to adult stage: a cluster analysis. Ge, R.S., Dong, Q., Sottas, C.M., Chen, H., Zirkin, B.R., Hardy, M.P. Biol. Reprod. (2005) [Pubmed]
  13. Zonal distribution of 11 beta-hydroxysteroid dehydrogenase types 1 and 2 messenger ribonucleic acid expression in the rat placenta and decidua during late pregnancy. Burton, P.J., Smith, R.E., Krozowski, Z.S., Waddell, B.J. Biol. Reprod. (1996) [Pubmed]
  14. Localization of an 11 beta hydroxysteroid dehydrogenase activity to the distal nephron. Evidence for the existence of two species of dehydrogenase in the rat kidney. Mercer, W.R., Krozowski, Z.S. Endocrinology (1992) [Pubmed]
  15. Aldosterone-sensitive neurons in the rat central nervous system. Geerling, J.C., Kawata, M., Loewy, A.D. J. Comp. Neurol. (2006) [Pubmed]
  16. Selective inhibition of sheep kidney 11 beta-hydroxysteroid dehydrogenase isoform 2 activity by 5 alpha-reduced (but not 5 beta) derivatives of adrenocorticosteroids. Latif, S.A., Sheff, M.F., Ribeiro, C.E., Morris, D.J. Steroids (1997) [Pubmed]
  17. Expression of 11 beta-hydroxysteroid dehydrogenase in rat osteoblastic cells: pre-receptor regulation of glucocorticoid responses in bone. Eyre, L.J., Rabbitt, E.H., Bland, R., Hughes, S.V., Cooper, M.S., Sheppard, M.C., Stewart, P.M., Hewison, M. J. Cell. Biochem. (2001) [Pubmed]
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