The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Fabp6  -  fatty acid binding protein 6, ileal

Rattus norvegicus

Synonyms: 14 kDa bile acid-binding protein, Fatty acid-binding protein 6, GT, Gastrotropin, I-15P, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fabp6


High impact information on Fabp6

  • The level of labyrinthine GT3 mRNA showed no change from midgestation through term; however, the volume of the labyrinth and hence total GT 3 gene expression increased greatly during this period [5].
  • Since this effect can occur without alteration in the expression of the two species of glucose transporters present in adipose cells or in their translocation to the plasma membrane in response to insulin, it may result from changes in GT functional activity [6].
  • Levels of the HepG2/brain GT protein and mRNA are unaltered by diabetes or phlorizin treatment [6].
  • Importantly, levels of the adipose/muscle GT protein remain 43% reduced in the low-density microsomes in the basal state and 46% reduced in the plasma membranes in the insulin-stimulated state [6].
  • Gelshift assays with nuclear extracts from rat ileum at different ages revealed absence of the DNA/protein complex in the second postnatal week when there is lack of IBABP expression and presence of these complexes at later ages when there is normally high expression [7].

Biological context of Fabp6


Anatomical context of Fabp6

  • Northern blot analysis revealed a single transcript of approximately 0.5 kb in ileum and ovary; however, the abundance of I-BABP mRNA was much greater in ileum than in ovary [9].
  • The deduced sequence of 127 amino acids was identical to that of rat I-15P which was purified from rat intestinal epithelium [10].
  • This high level of homology together with other features of I-BABP identify it as rat gastrotropin, establishing gastrotropin as the major intracellular bile acid carrier of rat enterocytes [11].
  • METHODS: Small and large cholangiocytes or intrahepatic bile duct units (IBDUs) were isolated from normal rats, and gene expression for the apical Na+-dependent bile acid transporter (ABAT) and the 14-kilodalton ileal cytosolic binding protein (IBABP) was assessed by ribonuclease-protection assays [12].
  • We and others have previously shown that, after exposure to phorbol esters, cultured fibroblasts exhibit increased expression of the mRNA encoding the HepG2/brain glucose transporter (GT mRNA) [13].

Associations of Fabp6 with chemical compounds

  • Northern blot analysis indicated that the same size of transcript as that of the ileum was detected in the ovary, suggesting that I-15P or a homologous protein might be involved in the metabolism of steroids in steroid hormone-producing tissues [10].
  • RESULTS: Taurocholate gavage significantly elevated IBABP messenger RNA and protein levels in suckling animals [7].
  • RESULTS: Cal I-1 significantly reduced I/R-mediated increases in urea, creatinine, gamma GT, AST, NAG, and FE(Na) and significantly improved C(Cr) [14].
  • Western blot analysis indicated increased levels of gamma GT protein with increasing menadione [15].
  • Plasma concentrations of urea, creatinine, Na(+), gamma-glutamyl transferase (gamma GT), aspartate aminotransferase (AST) and urinary Na(+), glutathione S-transferase (GST), and N-acetyl-beta-D-glucosaminidase (NAG) were measured for the assessment of renal dysfunction and I/R injury [14].

Other interactions of Fabp6


Analytical, diagnostic and therapeutic context of Fabp6


  1. The same gamma-glutamyl transpeptidase RNA species is expressed in fetal liver, hepatic carcinomas, and rasT24-transformed rat liver epithelial cells. Habib, G.M., Rajagopalan, S., Godwin, A.K., Lebovitz, R.M., Lieberman, M.W. Mol. Carcinog. (1992) [Pubmed]
  2. A role for superoxide in gentamicin-mediated nephropathy in rats. Cuzzocrea, S., Mazzon, E., Dugo, L., Serraino, I., Di Paola, R., Britti, D., De Sarro, A., Pierpaoli, S., Caputi, A., Masini, E., Salvemini, D. Eur. J. Pharmacol. (2002) [Pubmed]
  3. Role of glutathione metabolism in the reduction of proteinuria by dimethylthiourea in adriamycin nephrosis. Milner, L.S., Wei, S.H., Stohs, S.J., Eldeen, Z.M., Houser, M.T. Nephron (1992) [Pubmed]
  4. Effect of steroids on intestinal lipid uptake in rats is enhanced by a saturated fatty acid diet. Cell and molecular biology collaborative network in gastrointestinal physiology. Thiesen, A., Keelan, M., Wild, G., Clandinin, M.T., Agellon, L.B., Thomson, A.B. Digestion (2003) [Pubmed]
  5. Placental glucose transporter gene expression and metabolism in the rat. Zhou, J., Bondy, C.A. J. Clin. Invest. (1993) [Pubmed]
  6. Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression. Kahn, B.B., Shulman, G.I., DeFronzo, R.A., Cushman, S.W., Rossetti, L. J. Clin. Invest. (1991) [Pubmed]
  7. Bile acids regulate the ontogenic expression of ileal bile acid binding protein in the rat via the farnesoid X receptor. Hwang, S.T., Urizar, N.L., Moore, D.D., Henning, S.J. Gastroenterology (2002) [Pubmed]
  8. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonné, A., Gösele, C., den Bieman, M., Gillissen, G., Kreitler, T., Pravenec, M., Kren, V., van Lith, H., van Zutphen, B. Mol. Biol. Rep. (2003) [Pubmed]
  9. Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol. Gong, Y.Z., Everett, E.T., Schwartz, D.A., Norris, J.S., Wilson, F.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Cloning of a cDNA encoding rat intestinal 15 kDa protein and its tissue distribution. Fujii, H., Nomura, M., Kanda, T., Amano, O., Iseki, S., Hatakeyama, K., Ono, T. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  11. Identification of the 14 kDa bile acid transport protein of rat ileal cytosol as gastrotropin. Vodenlich, A.D., Gong, Y.Z., Geoghegan, K.F., Lin, M.C., Lanzetti, A.J., Wilson, F.A. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  12. Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes. Alpini, G., Glaser, S.S., Rodgers, R., Phinizy, J.L., Robertson, W.E., Lasater, J., Caligiuri, A., Tretjak, Z., LeSage, G.D. Gastroenterology (1997) [Pubmed]
  13. Overproduction of the beta 1 form of protein kinase C enhances phorbol ester induction of glucose transporter mRNA. Mountjoy, K.G., Housey, G.M., Flier, J.S. Mol. Endocrinol. (1989) [Pubmed]
  14. Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Chatterjee, P.K., Brown, P.A., Cuzzocrea, S., Zacharowski, K., Stewart, K.N., Mota-Filipe, H., McDonald, M.C., Thiemermann, C. Kidney Int. (2001) [Pubmed]
  15. gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. Kugelman, A., Choy, H.A., Liu, R., Shi, M.M., Gozal, E., Forman, H.J. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  16. Characterization of a novel 14 kDa bile acid-binding protein from rat ileal cytosol. Lin, M.C., Gong, Y.Z., Geoghegan, K.F., Wilson, F.A. Biochim. Biophys. Acta (1991) [Pubmed]
  17. Molecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat. Coppola, C.P., Gosche, J.R., Arrese, M., Ancowitz, B., Madsen, J., Vanderhoof, J., Shneider, B.L. Gastroenterology (1998) [Pubmed]
  18. Putrescine uptake in rat type II pneumocytes correlates with gamma-glutamyltransferase activity. van Klaveren, R.J., Hoet, P.H., Demedts, M., Nemery, B. Int. J. Biochem. Cell Biol. (1997) [Pubmed]
  19. Effect of different fixatives on immunocytochemical localization of HNK-1-reactive antigens in cerebellum: a method for differentiating the localization of the same carbohydrate epitope on proteins vs lipids. Prasadarao, N., Tobet, S.A., Jungalwala, F.B. J. Histochem. Cytochem. (1990) [Pubmed]
  20. Expression and localization of intestinal 15 kDa protein in the rat. Iseki, S., Amano, O., Kanda, T., Fujii, H., Ono, T. Mol. Cell. Biochem. (1993) [Pubmed]
WikiGenes - Universities