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Gene Review

Pck1  -  phosphoenolpyruvate carboxykinase 1 (soluble)

Rattus norvegicus

Synonyms: GTP, PCK, PEPCK-C, Pepck, RATPEPCK
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Disease relevance of Pck1


Psychiatry related information on Pck1

  • In young animals, food deprivation also: (i) reduced liver GK and PK, (ii) increased kidney PEPCK, (iii) decreased muscle PEPCK and (iv) decreased kidney PDH [6].

High impact information on Pck1


Chemical compound and disease context of Pck1


Biological context of Pck1


Anatomical context of Pck1


Associations of Pck1 with chemical compounds


Physical interactions of Pck1


Regulatory relationships of Pck1


Other interactions of Pck1


Analytical, diagnostic and therapeutic context of Pck1


  1. Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin. Sutherland, C., Waltner-Law, M., Gnudi, L., Kahn, B.B., Granner, D.K. J. Biol. Chem. (1998) [Pubmed]
  2. Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Yoo-Warren, H., Monahan, J.E., Short, J., Short, H., Bruzel, A., Wynshaw-Boris, A., Meisner, H.M., Samols, D., Hanson, R.W. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  3. Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene. Ip, Y.T., Poon, D., Stone, D., Granner, D.K., Chalkley, R. Mol. Cell. Biol. (1990) [Pubmed]
  4. Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells. Wynshaw-Boris, A., Lugo, T.G., Short, J.M., Fournier, R.E., Hanson, R.W. J. Biol. Chem. (1984) [Pubmed]
  5. Rat hepatic cytosolic phosphoenolpyruvate carboxykinase (GTP). Structures of the protein, messenger RNA, and gene. Beale, E.G., Chrapkiewicz, N.B., Scoble, H.A., Metz, R.J., Quick, D.P., Noble, R.L., Donelson, J.E., Biemann, K., Granner, D.K. J. Biol. Chem. (1985) [Pubmed]
  6. Enzymes of carbohydrate metabolism in young and adult rats fed diets differing in fat and carbohydrate. Brooks, S.P., Lampi, B.J. Mol. Cell. Biochem. (1996) [Pubmed]
  7. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Hanson, R.W., Reshef, L. Annu. Rev. Biochem. (1997) [Pubmed]
  8. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. Nyirenda, M.J., Lindsay, R.S., Kenyon, C.J., Burchell, A., Seckl, J.R. J. Clin. Invest. (1998) [Pubmed]
  9. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cool, B., Zinker, B., Chiou, W., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A., Gagne, G., Iyengar, R., Zhao, G., Marsh, K., Kym, P., Jung, P., Camp, H.S., Frevert, E. Cell metabolism. (2006) [Pubmed]
  10. Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats. Massillon, D., Chen, W., Barzilai, N., Prus-Wertheimer, D., Hawkins, M., Liu, R., Taub, R., Rossetti, L. J. Biol. Chem. (1998) [Pubmed]
  11. Insulin pulses less effective than continuous insulin in inhibiting PEPCK mRNA levels stimulated by cAMP and dexamethasone in perifused hepatoma cells. Harrison, H.C., Goodner, C.J., Berrie, M.A. Diabetes (1991) [Pubmed]
  12. Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP. Beale, E.G., Koch, S.R., Brotherton, A.F., Sheorain, V.S., Granner, D.K. Diabetes (1986) [Pubmed]
  13. Effects of 6- and 8-substituted analogs of adenosine 3':5'-monophosphate on phosphoenolpyruvate carboxykinase and tyrosine aminotransferase in hepatoma cell cultures. Wagner, K., Roper, M.D., Leichtling, B.H., Wimalasena, J., Wicks, W.D. J. Biol. Chem. (1975) [Pubmed]
  14. Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. Gabbay, R.A., Sutherland, C., Gnudi, L., Kahn, B.B., O'Brien, R.M., Granner, D.K., Flier, J.S. J. Biol. Chem. (1996) [Pubmed]
  15. SHARP-2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression. Yamada, K., Ogata-Kawata, H., Matsuura, K., Miyamoto, K. FEBS Lett. (2005) [Pubmed]
  16. Cysteine 288: an essential hyperreactive thiol of cytosolic phosphoenolpyruvate carboxykinase (GTP). Lewis, C.T., Seyer, J.M., Carlson, G.M. J. Biol. Chem. (1989) [Pubmed]
  17. Evidence for selective induction of phosphoenolpyruvate carboxykinase gene expression by unsaturated and nonmetabolized fatty acids in adipocytes. Duplus, E., Glorian, M., Tordjman, J., Berge, R., Forest, C. J. Cell. Biochem. (2002) [Pubmed]
  18. Kupffer cell cytokines interleukin-1beta and interleukin-10 combine to inhibit phosphoenolpyruvate carboxykinase and gluconeogenesis in cultured hepatocytes. Yerkovich, S.T., Rigby, P.J., Fournier, P.A., Olynyk, J.K., Yeoh, G.C. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  19. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains. Short, J.M., Wynshaw-Boris, A., Short, H.P., Hanson, R.W. J. Biol. Chem. (1986) [Pubmed]
  20. Coordinate regulation of gluconeogenesis by the glucocorticoids and glucagon: evidence for acute and chronic regulation by glucagon. Kletzien, R.F., Weber, C.A., Stumpo, D.J. J. Cell. Physiol. (1981) [Pubmed]
  21. A novel DNA/protein complex interacts with the insulin-like growth factor binding protein-1 (IGFBP-1) insulin response sequence and is required for maximal effects of insulin and glucocorticoids on promoter function. Unterman, T., Oehler, D., Ngyuen, H., Sengupta, P., Lacson, R. Prog. Growth Factor Res. (1995) [Pubmed]
  22. SREBP-1c and Sp1 interact to regulate transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in the liver. Chakravarty, K., Wu, S.Y., Chiang, C.M., Samols, D., Hanson, R.W. J. Biol. Chem. (2004) [Pubmed]
  23. Phosphoenolpyruvate carboxykinase is induced in growth-arrested hepatoma cells. Zeitouni, N., Eubank, D.W., Lee, A.Q., Oxford, M.G., Freeman, T.L., Mailliard, M.E., Beale, E.G. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  24. Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats. Torres, V.E., Sweeney, W.E., Wang, X., Qian, Q., Harris, P.C., Frost, P., Avner, E.D. Kidney Int. (2004) [Pubmed]
  25. PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis. Drewnowsk, K.D., Craig, M.R., Digiovanni, S.R., McCarty, J.M., Moorman, A.F., Lamers, W.H., Schoolwerth, A.C. J. Physiol. Pharmacol. (2002) [Pubmed]
  26. Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytes. Iynedjian, P.B., Marie, S., Gjinovci, A., Genin, B., Deng, S.P., Buhler, L., Morel, P., Mentha, G. J. Clin. Invest. (1995) [Pubmed]
  27. Messenger RNA for renal phosphoenolpyruvate carboxykinase (GTP). Its translation in a heterologous cell-free system and its regulation by glucocorticoids and by changes in acid-base balance. Iynedjian, P.B., Hanson, R.W. J. Biol. Chem. (1977) [Pubmed]
  28. Purification of a RNA-binding protein from rat liver. Identification as ferritin L chain and determination of the RNA/protein binding characteristics. Heise, T., Nath, A., Jungermann, K., Christ, B. J. Biol. Chem. (1997) [Pubmed]
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