Gene Review:
GRIN2B - glutamate receptor, ionotropic, N-methyl D...
Homo sapiens
Synonyms:
EIEE27, GluN2B, Glutamate receptor ionotropic, NMDA 2B, MRD6, N-methyl D-aspartate receptor subtype 2B, ...
Chavis,
Westbrook,
Xiong,
McCabe,
Skifter,
Monaghan,
Gendelman,
Dalmau,
Tüzün,
Wu,
Masjuan,
Rossi,
Voloschin,
Baehring,
Shimazaki,
Koide,
King,
Mason,
Sansing,
Dichter,
Rosenfeld,
Lynch,
Richter,
Chazot,
Pizzi,
Boroni,
Bianchetti,
Moraitis,
Sarnico,
Benarese,
Goffi,
Valerio,
Spano,
Arnold,
Rosenberg,
Mundo,
Tharmalingam,
Kennedy,
Richter,
Chazot,
Kliewer,
Goodwin,
Willson,
Allgaier,
Nash,
Ravenscroft,
McGuire,
Crossman,
Menniti,
Brotchie,
Di Maria,
Gulli,
Begni,
De Luca,
Bignotti,
Pasini,
Bellone,
Pizzuti,
Dallapiccola,
Novelli,
Ajmar,
Gennarelli,
Mandich,
Barria,
Malinow,
Bayer,
De Koninck,
Leonard,
Hell,
Schulman,
Clinton,
Haroutunian,
Meador-Woodruff,
Arning,
Kraus,
Valentin,
Saft,
Andrich,
Epplen,
- Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease. Tsai, S.J., Liu, H.C., Liu, T.Y., Cheng, C.Y., Hong, C.J. Journal of neural transmission (Vienna, Austria : 1996) (2002)
- Pharmacological and immunological characterization of N-methyl-D-aspartate receptors in human NT2-N neurons. Munir, M., Lu, L., Wang, Y.H., Luo, J., Wolfe, B.B., McGonigle, P. J. Pharmacol. Exp. Ther. (1996)
- The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Nash, J.E., Ravenscroft, P., McGuire, S., Crossman, A.R., Menniti, F.S., Brotchie, J.M. Exp. Neurol. (2004)
- Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Gao, J., Duan, B., Wang, D.G., Deng, X.H., Zhang, G.Y., Xu, L., Xu, T.L. Neuron (2005)
- Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Dalmau, J., Tüzün, E., Wu, H.Y., Masjuan, J., Rossi, J.E., Voloschin, A., Baehring, J.M., Shimazaki, H., Koide, R., King, D., Mason, W., Sansing, L.H., Dichter, M.A., Rosenfeld, M.R., Lynch, D.R. Ann. Neurol. (2007)
- N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. Martucci, L., Wong, A.H., De Luca, V., Likhodi, O., Wong, G.W., King, N., Kennedy, J.L. Schizophr. Res. (2006)
- Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Arnold, P.D., Rosenberg, D.R., Mundo, E., Tharmalingam, S., Kennedy, J.L., Richter, M.A. Psychopharmacology (Berl.) (2004)
- Association analysis for NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia. Hong, C.J., Yu, Y.W., Lin, C.H., Cheng, C.Y., Tsai, S.J. Psychiatr. Genet. (2001)
- N-methyl-D-aspartate receptor subunit NR2A and NR2B messenger RNA levels are altered in the hippocampus and entorhinal cortex in Alzheimer's disease. Bi, H., Sze, C.I. J. Neurol. Sci. (2002)
- The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Chazot, P.L. Current medicinal chemistry. (2004)
- Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse. Chavis, P., Westbrook, G. Nature (2001)
- Interaction with the NMDA receptor locks CaMKII in an active conformation. Bayer, K.U., De Koninck, P., Leonard, A.S., Hell, J.W., Schulman, H. Nature (2001)
- Genetic enhancement of learning and memory in mice. Tang, Y.P., Shimizu, E., Dube, G.R., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G., Tsien, J.Z. Nature (1999)
- The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Kliewer, S.A., Goodwin, B., Willson, T.M. Endocr. Rev. (2002)
- Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors. Song, C., Zhang, Y., Parsons, C.G., Liu, Y.F. J. Biol. Chem. (2003)
- CP-101606 Pfizer Inc. Chazot, P.L. Current opinion in investigational drugs (London, England : 2000) (2000)
- Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease. Nash, J.E., Fox, S.H., Henry, B., Hill, M.P., Peggs, D., McGuire, S., Maneuf, Y., Hille, C., Brotchie, J.M., Crossman, A.R. Exp. Neurol. (2000)
- The NMDA receptor NR2B subtype selective antagonist Ro 25-6981 aggravates paroxysmal dyskinesia in the dt(sz) mutant. Richter, A. Eur. J. Pharmacol. (2003)
- Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia. Ohtsuki, T., Sakurai, K., Dou, H., Toru, M., Yamakawa-Kobayashi, K., Arinami, T. Mol. Psychiatry (2001)
- Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12. Mandich, P., Schito, A.M., Bellone, E., Antonacci, R., Finelli, P., Rocchi, M., Ajmar, F. Genomics (1994)
- NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning, L., Kraus, P.H., Valentin, S., Saft, C., Andrich, J., Epplen, J.T. Neurogenetics (2005)
- An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Qin, S., Zhao, X., Pan, Y., Liu, J., Feng, G., Fu, J., Bao, J., Zhang, Z., He, L. Eur. J. Hum. Genet. (2005)
- mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit. Schito, A.M., Pizzuti, A., Di Maria, E., Schenone, A., Ratti, A., Defferrari, R., Bellone, E., Mancardi, G.L., Ajmar, F., Mandich, P. Neurosci. Lett. (1997)
- Differentiation of glycine antagonist sites of N-methyl-D-aspartate receptor subtypes. Preferential interaction of CGP 61594 with NR1/2B receptors. Honer, M., Benke, D., Laube, B., Kuhse, J., Heckendorn, R., Allgeier, H., Angst, C., Monyer, H., Seeburg, P.H., Betz, H., Mohler, H. J. Biol. Chem. (1998)
- Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease--an in situ hybridization study. Arzberger, T., Krampfl, K., Leimgruber, S., Weindl, A. J. Neuropathol. Exp. Neurol. (1997)
- Analysis of correlation between serum D-serine levels and functional promoter polymorphisms of GRIN2A and GRIN2B genes. Iwayama, Y., Hashimoto, K., Nakajima, M., Toyota, T., Yamada, K., Shimizu, E., Itokawa, M., Hoshika, A., Iyo, M., Yoshikawa, T. Neurosci. Lett. (2006)
- Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Zheng, F., Erreger, K., Low, C.M., Banke, T., Lee, C.J., Conn, P.J., Traynelis, S.F. Nat. Neurosci. (2001)
- NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Barria, A., Malinow, R. Neuron (2005)
- Regulation of calcium/calmodulin-dependent protein kinase II docking to N-methyl-D-aspartate receptors by calcium/calmodulin and alpha-actinin. Leonard, A.S., Bayer, K.U., Merrill, M.A., Lim, I.A., Shea, M.A., Schulman, H., Hell, J.W. J. Biol. Chem. (2002)
- Interleukin-1beta Released by gp120 Drives Neural Death through Tyrosine Phosphorylation and Trafficking of NMDA Receptors. Viviani, B., Gardoni, F., Bartesaghi, S., Corsini, E., Facchi, A., Galli, C.L., Di Luca, M., Marinovich, M. J. Biol. Chem. (2006)
- CaMKIIalpha enhances the desensitization of NR2B-containing NMDA receptors by an autophosphorylation-dependent mechanism. Sessoms-Sikes, S., Honse, Y., Lovinger, D.M., Colbran, R.J. Mol. Cell. Neurosci. (2005)
- NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. André, V.M., Flores-Hernández, J., Cepeda, C., Starling, A.J., Nguyen, S., Lobo, M.K., Vinters, H.V., Levine, M.S., Mathern, G.W. Cereb. Cortex (2004)
- Activation of NR1a/NR2B receptors by monocyte-derived macrophage secretory products: implications for human immunodeficiency virus type one-associated dementia. Xiong, H., McCabe, L., Skifter, D., Monaghan, D.T., Gendelman, H.E. Neurosci. Lett. (2003)
- Subunit dependencies of N-methyl-D-aspartate (NMDA) receptor-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization. Tigaret, C.M., Thalhammer, A., Rast, G.F., Specht, C.G., Auberson, Y.P., Stewart, M.G., Schoepfer, R. Mol. Pharmacol. (2006)
- Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Mathern, G.W., Pretorius, J.K., Mendoza, D., Leite, J.P., Chimelli, L., Born, D.E., Fried, I., Assirati, J.A., Ojemann, G.A., Adelson, P.D., Cahan, L.D., Kornblum, H.I. Ann. Neurol. (1999)
- Ethanol sensitivity of NMDA receptors. Allgaier, C. Neurochem. Int. (2002)
- Dopamine D2 receptor and N-methyl-D-aspartate receptor 2B subunit genetic variants and intelligence. Tsai, S.J., Yu, Y.W., Lin, C.H., Chen, T.J., Chen, S.P., Hong, C.J. Neuropsychobiology (2002)
- Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia. Clinton, S.M., Haroutunian, V., Meador-Woodruff, J.H. J. Neurochem. (2006)
- Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors. Hawkins, L.M., Chazot, P.L., Stephenson, F.A. J. Biol. Chem. (1999)
- Variations in the NMDA receptor subunit 2B gene (GRIN2B) and schizophrenia: a case-control study. Di Maria, E., Gulli, R., Begni, S., De Luca, A., Bignotti, S., Pasini, A., Bellone, E., Pizzuti, A., Dallapiccola, B., Novelli, G., Ajmar, F., Gennarelli, M., Mandich, P. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004)
- Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease. Hynd, M.R., Scott, H.L., Dodd, P.R. J. Neurochem. (2004)
- Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. Pizzi, M., Boroni, F., Bianchetti, A., Moraitis, C., Sarnico, I., Benarese, M., Goffi, F., Valerio, A., Spano, P. Eur. J. Neurosci. (2002)
- Protons trap NR1/NR2B NMDA receptors in a nonconducting state. Banke, T.G., Dravid, S.M., Traynelis, S.F. J. Neurosci. (2005)