Gene Review:
KCNN3 - potassium channel, calcium activated...
Homo sapiens
Synonyms:
K3, KCa2.3, SK3, SKCA3, SKCa 3, ...
- Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Tomita, H., Shakkottai, V.G., Gutman, G.A., Sun, G., Bunney, W.E., Cahalan, M.D., Chandy, K.G., Gargus, J.J. Mol. Psychiatry (2003)
- Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. Curtain, R., Sundholm, J., Lea, R., Ovcaric, M., MacMillan, J., Griffiths, L. BMC Med. Genet. (2005)
- Pharmacological and molecular characterisation of SK3 channels in the TE671 human medulloblastoma cell line. Carignani, C., Roncarati, R., Rimini, R., Terstappen, G.C. Brain Res. (2002)
- Distribution of Ca2+-activated K channels, SK2 and SK3, in the normal and Hirschsprung's disease bowel. Piotrowska, A.P., Solari, V., Puri, P. J. Pediatr. Surg. (2003)
- A highly polymorphic poly-glutamine stretch in the potassium channel KCNN3 in migraine. Mössner, R., Weichselbaum, A., Marziniak, M., Freitag, C.M., Lesch, K.P., Sommer, C., Meyer, J. Headache. (2005)
- Association and linkage studies between bipolar affective disorder and the polymorphic CAG/CTG repeat loci ERDA1, SEF2-1B, MAB21L and KCNN3. Meira-Lima, I.V., Zhao, J., Sham, P., Pereira, A.C., Krieger, J.E., Vallada, H. Mol. Psychiatry (2001)
- Association study of CAG repeats in the KCNN3 gene in Israeli patients with major psychosis. Ritsner, M., Amir, S., Koronyo-Hamaoui, M., Gak, E., Ziv, H., Halperin, T., Kitain, L., Navon, R. Psychiatr. Genet. (2003)
- Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder. Ujike, H., Yamamoto, A., Tanaka, Y., Takehisa, Y., Takaki, M., Taked, T., Kodama, M., Kuroda, S. Psychiatry research. (2001)
- hKCNN3 which maps to chromosome 1q21 is not the causative gene in periodic catatonia, a familial subtype of schizophrenia. Stöber, G., Meyer, J., Nanda, I., Wienker, T.F., Saar, K., Jatzke, S., Schmid, M., Lesch, K.P., Beckmann, H. European archives of psychiatry and clinical neuroscience. (2000)
- 3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR. Iwata, K., Fujiwara, T., Matsuki, Y., Akutsu, H., Takahashi, S., Naiki, H., Goto, Y. Proc. Natl. Acad. Sci. U.S.A. (2006)
- The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. Hoffman, J.F., Joiner, W., Nehrke, K., Potapova, O., Foye, K., Wickrema, A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility. Rhodes, J.D., Monckton, D.G., McAbney, J.P., Prescott, A.R., Duncan, G. Hum. Mol. Genet. (2006)
- Role of an S4-S5 linker lysine in the trafficking of the Ca(2+)-activated K(+) channels IK1 and SK3. Jones, H.M., Hamilton, K.L., Devor, D.C. J. Biol. Chem. (2005)
- Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. D'hoedt, D., Hirzel, K., Pedarzani, P., Stocker, M. J. Biol. Chem. (2004)
- Pharmacological modulation of SK3 channels. Grunnet, M., Jespersen, T., Angelo, K., Frøkjaer-Jensen, C., Klaerke, D.A., Olesen, S.P., Jensen, B.S. Neuropharmacology (2001)
- hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Dror, V., Shamir, E., Ghanshani, S., Kimhi, R., Swartz, M., Barak, Y., Weizman, R., Avivi, L., Litmanovitch, T., Fantino, E., Kalman, K., Jones, E.G., Chandy, K.G., Gargus, J.J., Gutman, G.A., Navon, R. Mol. Psychiatry (1999)
- Genomic organization and promoter analysis of human KCNN3 gene. Sun, G., Tomita, H., Shakkottai, V.G., Gargus, J.J. J. Hum. Genet. (2001)
- Schizophrenia and polymorphic CAG repeats array of calcium-activated potassium channel (KCNN3) gene in Serbian population. Ivković, M., Ranković, V., Tarasjev, A., Orolicki, S., Damjanović, A., Paunović, V.R., Romac, S. Int. J. Neurosci. (2006)
- Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Terstappen, G.C., Pula, G., Carignani, C., Chen, M.X., Roncarati, R. Neuropharmacology (2001)
- Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Chen, M.X., Gorman, S.A., Benson, B., Singh, K., Hieble, J.P., Michel, M.C., Tate, S.N., Trezise, D.J. Naunyn Schmiedebergs Arch. Pharmacol. (2004)
- Interactions of N-Terminal and C-Terminal Parts of the Small Conductance Ca Activated K(+) Channel, hSK3. Frei, E., Spindler, I., Grissmer, S., Jager, H. Cell. Physiol. Biochem. (2006)
- Small conductance Ca2+-activated K+ channels as targets of CNS drug development. Blank, T., Nijholt, I., Kye, M.J., Spiess, J. Current drug targets. CNS and neurological disorders. (2004)
- Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. Wulff, H., Gutman, G.A., Cahalan, M.D., Chandy, K.G. J. Biol. Chem. (2001)
- An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel. Wittekindt, O.H., Visan, V., Tomita, H., Imtiaz, F., Gargus, J.J., Lehmann-Horn, F., Grissmer, S., Morris-Rosendahl, D.J. Mol. Pharmacol. (2004)
- CAG repeat polymorphisms in KCNN3 (HSKCa3) and PPP2R2B show no association or linkage to schizophrenia. Laurent, C., Niehaus, D., Bauché, S., Levinson, D.F., Soubigou, S., Pimstone, S., Hayden, M., Mbanga, I., Emsley, R., Deleuze, J.F., Mallet, J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)
- No evidence for involvement of KCNN3 (hSKCa3) potassium channel gene in familial and isolated cases of schizophrenia. Bonnet-Brilhault, F., Laurent, C., Campion, D., Thibaut, F., Lafargue, C., Charbonnier, F., Deleuze, J.F., Ménard, J.F., Jay, M., Petit, M., Frebourg, T., Mallet, J. Eur. J. Hum. Genet. (1999)
- Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. Miller, M.J., Rauer, H., Tomita, H., Rauer, H., Gargus, J.J., Gutman, G.A., Cahalan, M.D., Chandy, K.G. J. Biol. Chem. (2001)
- CAG repeats of CTG18.1 and KCNN3 in Korean patients with bipolar affective disorder. Jin, D.K., Hwang, H.Z., Oh, M.R., Kim, J.S., Lee, M., Kim, S., Lim, S.W., Seo, M.Y., Kim, J.H., Kim, D.K. Journal of affective disorders. (2001)
- CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies. Glatt, S.J., Faraone, S.V., Tsuang, M.T. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2003)
- CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population. Koronyo-Hamaoui, M., Gak, E., Stein, D., Frisch, A., Danziger, Y., Leor, S., Michaelovsky, E., Laufer, N., Carel, C., Fennig, S., Mimouni, M., Apter, A., Goldman, B., Barkai, G., Weizman, A. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004)