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Gene Review

Lhb  -  luteinizing hormone beta polypeptide

Rattus norvegicus

Synonyms: LH-B, LSH-B, LSH-beta, Luteinizing hormone subunit beta, Lutropin beta chain, ...
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Disease relevance of Lhb


Psychiatry related information on Lhb

  • Cytotoxic lesions of the entire Lhb prevented the onset of all components of maternal behavior compared with controls [3].

High impact information on Lhb

  • These results suggest that GnRHa differentially activates ERK and JNK, and a JNK cascade is necessary to elicit the rat LHbeta promoter activity in a c-Jun-dependent mechanism in LbetaT2 cells [4].
  • GnRH activated the rat LHbeta promoter activity in a time-dependent manner [4].
  • Identification of an estrogen-responsive element in the rat LH beta gene. DNA-estrogen receptor interactions and functional analysis [2].
  • A construct containing a synthetic oligonucleotide of this putative LH beta ERE was stimulated 1.7-3-fold by E2, while a construct containing two copies of the sequence was stimulated to a slightly higher level (2.5-4.0-fold) [2].
  • The 15-base pair LH beta gene palindrome was found to bind estrogen receptor (ER) complex directly by gel retardation experiments [2].

Chemical compound and disease context of Lhb


Biological context of Lhb


Anatomical context of Lhb


Associations of Lhb with chemical compounds


Physical interactions of Lhb


Regulatory relationships of Lhb


Other interactions of Lhb


Analytical, diagnostic and therapeutic context of Lhb


  1. Expression of chorionic gonadotrophin in human pituitary adenomas. Levy, A., Biswas, S., Burton, P.A., Lightman, S.L. Eur. J. Endocrinol. (1994) [Pubmed]
  2. Identification of an estrogen-responsive element in the rat LH beta gene. DNA-estrogen receptor interactions and functional analysis. Shupnik, M.A., Rosenzweig, B.A. J. Biol. Chem. (1991) [Pubmed]
  3. Neurons in the lateral subdivision of the habenular complex mediate the hormonal onset of maternal behavior in rats. Corodimas, K.P., Rosenblatt, J.S., Canfield, M.E., Morrell, J.I. Behav. Neurosci. (1993) [Pubmed]
  4. Activation of the luteinizing hormone beta promoter by gonadotropin-releasing hormone requires c-Jun NH2-terminal protein kinase. Yokoi, T., Ohmichi, M., Tasaka, K., Kimura, A., Kanda, Y., Hayakawa, J., Tahara, M., Hisamoto, K., Kurachi, H., Murata, Y. J. Biol. Chem. (2000) [Pubmed]
  5. Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. Kaiser, U.B., Sabbagh, E., Chen, M.T., Chin, W.W., Saunders, B.D. J. Biol. Chem. (1998) [Pubmed]
  6. Progesterone together with estradiol promotes luteinizing hormone beta-subunit mRNA stability in rat pituitary cells cultured in vitro. Park, D., Cheon, M., Kim, C., Kim, K., Ryu, K. Eur. J. Endocrinol. (1996) [Pubmed]
  7. Regulation of expression of secretogranin II mRNA in female rat pituitary and hypothalamus. Kakar, S.S., Wei, N., Mulchahey, J.J., LeBoeuf, R.D., Neill, J.D. Neuroendocrinology (1993) [Pubmed]
  8. Plasma testosterone surge and luteinizing hormone beta (LH-beta) following parturition: lack of association in the male rat. McGivern, R.F., Hermans, R.H., Handa, R.J., Longo, L.D. Eur. J. Endocrinol. (1995) [Pubmed]
  9. Mechanisms involved in the pituitary desensitization induced by gonadotropin-releasing hormone agonists. Uemura, T., Yanagisawa, T., Shirasu, K., Matsuyama, A., Minaguchi, H. Am. J. Obstet. Gynecol. (1992) [Pubmed]
  10. Bihormonal cells producing gonadotropins and prolactin in a rat pituitary tumor cell line (RC-4B/C). Polkowska, J., Bérault, A., Hurbain-Kosmath, I., Jolly, G., Jutisz, M. Neuroendocrinology (1991) [Pubmed]
  11. Neuroanatomical tract tracing provides histological verification of neuron loss following cytotoxic lesions. Corodimas, K.P., Rosenblatt, J.S., Matthews, T.M., Morrell, J.I. J. Neurosci. Methods (1995) [Pubmed]
  12. Differential activation by xenoestrogens of ER alpha and ER beta when linked to different response elements. Pennie, W.D., Aldridge, T.C., Brooks, A.N. J. Endocrinol. (1998) [Pubmed]
  13. Gonadotropin-releasing hormone activation of c-jun, but not early growth response factor-1, stimulates transcription of a luteinizing hormone beta-subunit gene. Melamed, P., Zhu, Y., Tan, S.H., Xie, M., Koh, M. Endocrinology (2006) [Pubmed]
  14. Differential regulation of anterior pituitary prodynorphin and gonadotropin-subunit gene expression by steroid hormones. Kaynard, A.H., Low, K.G., Melner, M.H. Mol. Cell. Endocrinol. (1992) [Pubmed]
  15. Effect of chronic ethanol diet on expression of gonadotropin genes in the male rat. Salonen, I., Pakarinen, P., Huhtaniemi, I. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  16. Small nuclear RING finger protein stimulates the rat luteinizing hormone-beta promoter by interacting with Sp1 and steroidogenic factor-1 and protects from androgen suppression. Curtin, D., Ferris, H.A., Häkli, M., Gibson, M., Jänne, O.A., Palvimo, J.J., Shupnik, M.A. Mol. Endocrinol. (2004) [Pubmed]
  17. Differential expression of gonadotropin and prolactin antigens by GHRH target cells from male and female rats. Childs, G.V., Unabia, G., Miller, B.T., Collins, T.J. J. Endocrinol. (1999) [Pubmed]
  18. Differential effect of baclofen on hypothalamic GnRH and pituitary LH beta gene expression in steroid-treated rats. Cho, B.N., Kim, K. Mol. Cells (1997) [Pubmed]
  19. Ovariectomy-evoked increase in gonadotropin releasing hormone receptor parallels its messenger RNA level, but does not correlate with stimulated gonadotropin release. Saito, S., Izumi, S., Kobayashi, M., Saitoh, S., Makino, T., Yoshimura, Y., Nozawa, S., Takamatsu, K. Endocr. J. (1996) [Pubmed]
  20. Detection of luteinizing hormone beta messenger ribonucleic acid (RNA) in individual gonadotropes after castration: use of a new in situ hybridization method with a photobiotinylated complementary RNA probe. Childs, G.V., Lloyd, J.M., Unabia, G., Gharib, S.D., Wierman, M.E., Chin, W.W. Mol. Endocrinol. (1987) [Pubmed]
  21. Alpha and luteinizing hormone beta messenger ribonucleic acid (RNA) of male and female rats after castration: quantitation using an optimized RNA dot blot hybridization assay. Papavasiliou, S.S., Zmeili, S., Herbon, L., Duncan-Weldon, J., Marshall, J.C., Landefeld, T.D. Endocrinology (1986) [Pubmed]
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