Gene Review:
Lhb - luteinizing hormone beta
Mus musculus
Synonyms:
LH, LH-B, LSH-B, LSH-beta, Luteinizing hormone subunit beta, ...
- Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Lee, S.L., Sadovsky, Y., Swirnoff, A.H., Polish, J.A., Goda, P., Gavrilina, G., Milbrandt, J. Science (1996)
- Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition. Bowen, R.L., Verdile, G., Liu, T., Parlow, A.F., Perry, G., Smith, M.A., Martins, R.N., Atwood, C.S. J. Biol. Chem. (2004)
- The gonadotropin connection in Alzheimer's disease. Meethal, S.V., Smith, M.A., Bowen, R.L., Atwood, C.S. Endocrine (2005)
- Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. Kero, J., Poutanen, M., Zhang, F.P., Rahman, N., McNicol, A.M., Nilson, J.H., Keri, R.A., Huhtaniemi, I.T. J. Clin. Invest. (2000)
- Effects of galanin-like peptide (GALP) on locomotion, reproduction, and body weight in female and male mice. Kauffman, A.S., Buenzle, J., Fraley, G.S., Rissman, E.F. Hormones and behavior. (2005)
- Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Kumar, T.R., Wang, Y., Lu, N., Matzuk, M.M. Nat. Genet. (1997)
- Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function. Themmen APN, n.u.l.l., Huhtaniemi, I.T. Endocr. Rev. (2000)
- Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1. Dorn, C., Ou, Q., Svaren, J., Crawford, P.A., Sadovsky, Y. J. Biol. Chem. (1999)
- Consequences of elevated luteinizing hormone on diverse physiological systems: use of the LHbetaCTP transgenic mouse as a model of ovarian hyperstimulation-induced pathophysiology. Mann, R.J., Keri, R.A., Nilson, J.H. Recent Prog. Horm. Res. (2003)
- Biologically active luteinizing hormone (LH) in Klinefelter's syndrome: response to gonadotropin-releasing hormone (GnRH) and effects of testosterone undecanoate. Montanini, V., Celani, M.F., Carani, C., Cioni, K., Simoni, M., Baraghini, G.F., Marrama, P. Andrologia (1987)
- Extragonadal effects of luteinizing hormone in mice. Nomura, K., Puett, D.W., Puett, D., Shizume, K., Liddle, G.W. Acta Endocrinol. (1989)
- Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis. Tourtellotte, W.G., Nagarajan, R., Bartke, A., Milbrandt, J. Mol. Cell. Biol. (2000)
- A steroidogenic factor-1 binding site is required for activity of the luteinizing hormone beta subunit promoter in gonadotropes of transgenic mice. Keri, R.A., Nilson, J.H. J. Biol. Chem. (1996)
- Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. Halvorson, L.M., Ito, M., Jameson, J.L., Chin, W.W. J. Biol. Chem. (1998)
- A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene. Sevetson, B.R., Svaren, J., Milbrandt, J. J. Biol. Chem. (2000)
- Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice. Beuschlein, F., Looyenga, B.D., Bleasdale, S.E., Mutch, C., Bavers, D.L., Parlow, A.F., Nilson, J.H., Hammer, G.D. Mol. Cell. Biol. (2003)
- Steroid and pulsatile gonadotropin-releasing hormone (GnRH) regulation of luteinizing hormone and GnRH receptor in a novel gonadotrope cell line. Turgeon, J.L., Kimura, Y., Waring, D.W., Mellon, P.L. Mol. Endocrinol. (1996)
- Analysis of ovarian gene expression in follicle-stimulating hormone beta knockout mice. Burns, K.H., Yan, C., Kumar, T.R., Matzuk, M.M. Endocrinology (2001)
- The calcium component of gonadotropin-releasing hormone-stimulated luteinizing hormone subunit gene transcription is mediated by calcium/calmodulin-dependent protein kinase type II. Haisenleder, D.J., Ferris, H.A., Shupnik, M.A. Endocrinology (2003)
- Dependence of uterine cyclooxygenase2 expression on luteinizing hormone signaling. Lin, D.X., Lei, Z.M., Rao, C.h.V. Biol. Reprod. (2005)
- Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta. Couse, J.F., Yates, M.M., Walker, V.R., Korach, K.S. Mol. Endocrinol. (2003)
- Melatonin acts in the brain to mediate seasonal steroid inhibition of luteinizing hormone secretion in the white-footed mouse (Peromyscus leucopus). Glass, J.D., Dolan, P.L. Proc. Soc. Exp. Biol. Med. (1988)
- Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor. Quirk, C.C., Seachrist, D.D., Nilson, J.H. J. Biol. Chem. (2003)
- Modulation of luteinizing hormone receptors: effect of an inhibitor of prolactin secretion, p-coumaric acid. Chowdhury, M., Kabir, S.N., Pal, A.K., Pakrashi, A. J. Endocrinol. (1983)
- Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Bédécarrats, G.Y., O'Neill, F.H., Norwitz, E.R., Kaiser, U.B., Teixeira, J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription. Tremblay, J.J., Drouin, J. Mol. Cell. Biol. (1999)
- Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse. Dorling, A.A., Todman, M.G., Korach, K.S., Herbison, A.E. Neuroendocrinology (2003)
- The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats. Watanobe, H., Schiöth, H.B., Wikberg, J.E., Suda, T. Biochem. Biophys. Res. Commun. (1999)
- Immortalization of pituitary cells at discrete stages of development by directed oncogenesis in transgenic mice. Alarid, E.T., Windle, J.J., Whyte, D.B., Mellon, P.L. Development (1996)
- Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1. Halvorson, L.M., Kaiser, U.B., Chin, W.W. J. Biol. Chem. (1996)
- Targeted ablation of cells in the pituitary primordia of transgenic mice. Burrows, H.L., Birkmeier, T.S., Seasholtz, A.F., Camper, S.A. Mol. Endocrinol. (1996)
- Effect of steroid milieu on gonadotropin-releasing hormone-1 neuron firing pattern and luteinizing hormone levels in male mice. Pielecka, J., Moenter, S.M. Biol. Reprod. (2006)
- Effects of acute stimulation with gonadotropin releasing hormone (GnRH) on biologically active serum luteinizing hormone (LH) in elderly men. Celani, M.F., Montanini, V., Baraghini, G.F., Carani, C., Marrama, P. J. Endocrinol. Invest. (1984)
- Targeted ablation of gonadotrophs in transgenic mice depresses prolactin but not growth hormone gene expression at birth as measured by quantitative mRNA detection. Vankelecom, H., Seuntjens, E., Hauspie, A., Denef, C. J. Biomed. Sci. (2003)