Disease relevance of SLC25A3

• These studies suggest that persistent HBV infection is a dynamic process, with replicative and nonreplicative phases, that nonreplicative infection may be the precursor of PHC, and that the natural history of persistent infection can be modified by a variety of factors, including viral reactivation and viral superinfections [1].
• Banding cytogenetics and fluorescence in situ hybridization analysis of a pulmonary chondroid hamartoma (PHC) showed the presence of a t(6;10)(p21;q22) [2].
• OBJECTIVE: We examined differences in distress (i.e., depression, anxiety, and somatisation) and hopelessness (e.g., suicide ideation) among parents of congenital heart disease (CHD) children (PCCHD, n=1092), parents of children with other diseases (PCOD, n=112), and parents of healthy children (PHC, n=293) [3].
• Colonic varices and PHC were present simultaneously in 27 % of the patients [4].
• Octreotide is a safe and effective treatment for severe acute bleeding from PHC, especially if the patient is not a candidate for transjugular intrahepatic portosystemic shunt (TIPS) or treatment with a beta-blocker due to the severity of liver disease or haemodynamic instability [5].

Psychiatry related information on SLC25A3

• Evaluation of ICD-10 PHC mental health guidelines in detecting and managing depression within primary care [6].
• Proper management of PHC teams is equally important to ensure both job satisfaction of team members and "consumer" satisfaction and improvement of health status for the people [7].

High impact information on SLC25A3

• The locations of the alpha and gamma subunits of the mitochondrial ATP synthase complex and the mitochondrial phosphate carrier, PHC, on human chromosomes were determined using cloned rat liver cDNA as probes [8].
• Human homologues of the alpha subunit are on chromosomes 9 and 18, the gamma subunit are on chromosomes 10 and 14, and the PHC was localized to chromosome 12 [8].
• The cell lines included PLC/PRF/5 (Alexander cell line), Hep3B, HepG2, TONG PHC, HA22T/VGH, HA59T/VGH and Mahlavu [9].
• RESULTS: Colonic varices were observed in 31 % of the patients, portal hypertensive colopathy (PHC; defined as diffuse hyperemia, edema, spider angiomas, and spontaneous bleeding of the colonic mucosa) in 54 %, and normal colonic findings in 18 % [4].
• Some MCs have isoforms encoded by different SLC25 genes, whereas the phosphate carrier has two variants arising from an alternative splicing of SLC25A3 [10].

Chemical compound and disease context of SLC25A3

• A longitudinal study to monitor chloroquine-resistant P. falciparum malaria in Bokajan and Manja PHC areas of Karbi Anglong District, Assam [11].
• In benign liver tumours dermatan sulfate, in PHC and renal cell carcinoma chondroitin sulfate, but in Wilms' tumour hyaluronate was the prominent GAG subclass [12].

Biological context of SLC25A3

• Three nuclear genome encoded membrane proteins, namely, the phosphate carrier (PHC), the adenine nucleotide carrier (ANT), and the ATP synthase complex, consisting of at least 13 individual subunits, catalyze these reactions [8].
• The extra facilities in the PHC villages include: a paid Community Health Nurse for about every 5 villages, a Village Health Worker and a trained Traditional Birth Attendant [13].
• The MPS was easy and inexpensive to implement in existing public health care systems with the information material developed for the study and with physicians in PHC facilities [14].
• Family practice trained doctors will function in a PHC system in which the services provided are not coordinated [15].
• Transfection assay of NIH 3T3 cells was performed with DNAs isolated from ten human PHC (primary hepatic cancer) specimens and a hepatoma 7402 cell line [16].

Anatomical context of SLC25A3

• These agents increased class II and class II human leucocyte antigen expression on HA22T/VGH and TONG PHC cells, but had no effect on the HA59T/VGH cell line [9].
• The common leukocyte antigen marker CD45, pan T-cell marker CD3, monocyte/macrophage marker CD14 and B-cell marker CD19 were retained after exposure to the PHC cocktail of enzymes [17].

Associations of SLC25A3 with chemical compounds

• The effects of modulating agents such as interferon-gamma sodium butyrate and clofazimine on human leucocyte antigen expression were investigated using the HA22T/VGH, HA59T/VGH and TONG PHC cell lines [9].
• Propranolol treatment before discontinuation of octreotide infusin prevented the recurrence of bleeding from PHC [5].
• We have evaluated 619 aspartic ketones with 9 different types of prime-side groups (acyloxymethyl, aryloxymethyl, arylthiomethyl, alkylthiomethyl, acylamino-oxymethyl, sulfonylaminomethyl, alpha-ketoamide, alpha-(1-phenyl-3-trifluoromethyl-pyrazol-5-yl)oxymethyl (PTP), and aliphatic ketones) as inhibitors of caspase-1 [18].
• In-vivo as well as in-vitro studies were carried out at regular intervals from 1979 to 1988 to monitor chloroquine resistance in P. falciparum in Bokajan and Manja PHC of Karbi Anglong district, Assam. The results showed no significant change in resistance status in the area [11].
• Both iron as well as vitamin A supplementation through the PHC system appear to be low cost interventions [19].

Analytical, diagnostic and therapeutic context of SLC25A3

• Liver samples were taken before and after each event in a two-cycle ischemia-reperfusion protocol using 15 minutes of PHC followed by 5 minutes of reperfusion [20].
• Intermittent clamping of the porta hepatis (PHC) is commonly performed during liver surgery to reduce blood loss and has been reported to precondition livers resulting in improved outcome after liver surgery (humans) and transplantation (animals) [20].
• Maternal and child health services with a vaccination programme are accessible to residents in both PHC and non-PHC villages [13].
• Colonoscopy revealed multiple angiodysplasia-like lesions and mucosal friability throughout the entire colon (portal hypertensive colopathy, PHC) [5].
• Nursing in support of PHC: let us think about traditional medicine [21].

References