Gene Review:
Tyk2 - tyrosine kinase 2
Mus musculus
Synonyms:
JTK1, Non-receptor tyrosine-protein kinase TYK2
Numata,
Nakayama,
Sekiguchi,
Miyamoto,
Niho,
Shibata,
Thompson,
Kitamura,
Karaghiosoff,
Kobayashi,
Nakayama,
Steinborn,
Cameron,
Shibata,
Takase,
Nakajima,
Gondo,
Shimoda,
Okamura,
Frankshun,
Jonjic,
Müller,
Kato,
Weng,
Bruns,
Bubic,
Cubbon,
Liverton,
Strobl,
Okamura,
Cummings,
Aoki,
Kalinke,
Lajko,
Kumagai,
Kolbe,
Shibamori,
Cunningham,
Matsuda,
DeMartino,
Asano,
Nakayama,
Yamashita,
Meinke,
Shimoda,
Wicker,
- Partial impairment of cytokine responses in Tyk2-deficient mice. Karaghiosoff, M., Neubauer, H., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., Pfeffer, K., Müller, M. Immunity (2000)
- Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. Gamero, A.M., Potla, R., Wegrzyn, J., Szelag, M., Edling, A.E., Shimoda, K., Link, D.C., Dulak, J., Baker, D.P., Tanabe, Y., Grayson, J.M., Larner, A.C. J. Biol. Chem. (2006)
- A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity. Shaw, M.H., Boyartchuk, V., Wong, S., Karaghiosoff, M., Ragimbeau, J., Pellegrini, S., Muller, M., Dietrich, W.F., Yap, G.S. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Tyk2 Signaling in Host Environment Plays an Important Role in Contraction of Antigen-Specific CD8+ T Cells following a Microbial Infection. Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K., Yoshikai, Y. J. Immunol. (2007)
- Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. Shaw, M.H., Freeman, G.J., Scott, M.F., Fox, B.A., Bzik, D.J., Belkaid, Y., Yap, G.S. J. Immunol. (2006)
- Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Watling, D., Guschin, D., Müller, M., Silvennoinen, O., Witthuhn, B.A., Quelle, F.W., Rogers, N.C., Schindler, C., Stark, G.R., Ihle, J.N. Nature (1993)
- Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Diefenbach, A., Schindler, H., Röllinghoff, M., Yokoyama, W.M., Bogdan, C. Science (1999)
- Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Minegishi, Y., Saito, M., Morio, T., Watanabe, K., Agematsu, K., Tsuchiya, S., Takada, H., Hara, T., Kawamura, N., Ariga, T., Kaneko, H., Kondo, N., Tsuge, I., Yachie, A., Sakiyama, Y., Iwata, T., Bessho, F., Ohishi, T., Joh, K., Imai, K., Kogawa, K., Shinohara, M., Fujieda, M., Wakiguchi, H., Pasic, S., Abinun, M., Ochs, H.D., Renner, E.D., Jansson, A., Belohradsky, B.H., Metin, A., Shimizu, N., Mizutani, S., Miyawaki, T., Nonoyama, S., Karasuyama, H. Immunity (2006)
- Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y., Nakayama, K. Immunity (2000)
- Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx. Aoki, K., Shimoda, K., Oritani, K., Matsuda, T., Kamezaki, K., Muromoto, R., Numata, A., Tamiya, S., Haro, T., Ishikawa, F., Takase, K., Yamamoto, T., Yumioka, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K., Harada, M. Exp. Hematol. (2003)
- The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. Ragimbeau, J., Dondi, E., Alcover, A., Eid, P., Uzé, G., Pellegrini, S. EMBO J. (2003)
- Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. Strobl, B., Bubic, I., Bruns, U., Steinborn, R., Lajko, R., Kolbe, T., Karaghiosoff, M., Kalinke, U., Jonjic, S., Müller, M. J. Immunol. (2005)
- Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth. Kato, K., Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Aoki, K., Ishikawa, F., Takase, K., Ariyama, H., Matsuda, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nakayama, K., Harada, M. Br. J. Haematol. (2003)
- Regulation of Lipopolysaccharide-Induced Inducible Nitric-Oxide Synthase Expression through the Nuclear Factor-{kappa}B Pathway and Interferon-beta/Tyrosine Kinase 2/Janus Tyrosine Kinase 2-Signal Transducer and Activator of Transcription-1 Signaling Cascades by 2-Naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (THI 53), a New Synthetic Isoquinoline Alkaloid. Kim, H.J., Tsoyi, K., Heo, J.M., Kang, Y.J., Park, M.K., Lee, Y.S., Lee, J.H., Seo, H.G., Yun-Choi, H.S., Chang, K.C. J. Pharmacol. Exp. Ther. (2007)
- Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshäuser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., Müller, M. Nat. Immunol. (2003)
- Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Pan, J., Fukuda, K., Saito, M., Matsuzaki, J., Kodama, H., Sano, M., Takahashi, T., Kato, T., Ogawa, S. Circ. Res. (1999)
- Conditional activation of Janus kinase (JAK) confers factor independence upon interleukin-3-dependent cells. Essential role of Ras in JAK-triggered mitogenesis. Mizuguchi, R., Hatakeyama, M. J. Biol. Chem. (1998)
- Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Thompson, J.E., Cubbon, R.M., Cummings, R.T., Wicker, L.S., Frankshun, R., Cunningham, B.R., Cameron, P.M., Meinke, P.T., Liverton, N., Weng, Y., DeMartino, J.A. Bioorg. Med. Chem. Lett. (2002)
- Control of Leishmania major in the absence of Tyk2 kinase. Schleicher, U., Mattner, J., Blos, M., Schindler, H., Röllinghoff, M., Karaghiosoff, M., Müller, M., Werner-Felmayer, G., Bogdan, C. Eur. J. Immunol. (2004)
- Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation. Tokumasa, N., Suto, A., Kagami, S., Furuta, S., Hirose, K., Watanabe, N., Saito, Y., Shimoda, K., Iwamoto, I., Nakajima, H. Blood (2007)
- The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Kamezaki, K., Shimoda, K., Numata, A., Matsuda, T., Nakayama, K., Harada, M. Int. Immunol. (2004)
- Jak2 and Tyk2 are necessary for lineage-specific differentiation, but not for the maintenance of self-renewal of mouse embryonic stem cells. Chung, B.M., Kang, H.C., Han, S.Y., Heo, H.S., Lee, J.J., Jeon, J., Lim, J.Y., Shin, I., Hong, S.H., Cho, Y.S., Kim, C.G. Biochem. Biophys. Res. Commun. (2006)
- Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. Seto, Y., Nakajima, H., Suto, A., Shimoda, K., Saito, Y., Nakayama, K.I., Iwamoto, I. J. Immunol. (2003)
- Tyk2 is dispensable for induction of myeloproliferative disease by mutant FLT3. Nakajima, H., Shibata, F., Kumagai, H., Shimoda, K., Kitamura, T. Int. J. Hematol. (2006)