Disease relevance of Prozac

• Severe neutropenia associated with fluoxetine hydrochloride [1].
• Fluoxetine hydrochloride for the treatment of severe refractory orthostatic hypotension [2].
• Treatment of fibrositis with fluoxetine hydrochloride (Prozac) [3].
• 2. Intraperitoneal administration of either Lilly 110140 or chlorimipramine produced dose-dependent hypothermia at 8 and 22 degrees C Ta [4].
• Possible association between fluoxetine hydrochloride and colic in an infant [5].

Psychiatry related information on Prozac

• OBJECTIVES: To determine the effectiveness of fluoxetine hydrochloride at fixed doses of 20 mg/d, 40 mg/d, and 60 mg/d in patients with obsessive-compulsive disorder (OCD) and to evaluate its safety [6].
• METHODS: Adult smokers (n=175) without clinically significant depression were randomized on a double-blind basis to receive fluoxetine hydrochloride (30 or 60 mg daily) or placebo for 10 weeks in combination with cognitive-behavioral therapy (CBT) for smoking cessation [7].
• Effects of Lilly 110140 (flouxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse [8].
• This article reviews 12 criminal cases in the United States in which Prozac victimization is a salient theme, and it calls for mental health professional organizations to intervene in a growing legal conundrum [9].
• Questions & answers. What is Symbyax, the new drug being marketed for the treatment of bipolar depression [10].

High impact information on Prozac

• OBJECTIVE--To compare pregnancy outcome following first-trimester fluoxetine (Prozac) exposure with pregnancy outcome in two matched control groups [11].
• PATIENTS AND OTHER PARTICIPANTS: We matched 19 medication-free, acutely symptomatic patients satisfying DSM-IV criteria for unipolar major depressive disorder by age, sex, and IQ with 19 healthy volunteers.Intervention After the baseline assessment, patients received fluoxetine hydrochloride, 20 mg/d, for 8 weeks [12].
• We used positron emission tomography to investigate local cerebral metabolic rates for glucose (LCMRG1c) in patients with obsessive-compulsive disorder before and after treatment with either fluoxetine hydrochloride or behavior therapy [13].
• After treatment with fluoxetine hydrochloride she became anorexic and her serum digoxin level increased [14].
• This increased gene expression is reversed by chronic fluoxetine hydrochloride (Prozac) treatment [15].

Chemical compound and disease context of Prozac

• Treatment with fluoxetine hydrochloride was compared with treatment with clomipramine hydrochloride in two groups of patients with obsessive-compulsive disorder using two different experimental designs [16].
• The effect of fluoxetine (Prozac) on 5-hydroxytryptamine(3) (5-HT(3))-mediated currents in NCB-20 neuroblastoma cells was examined using the whole-cell patch-clamp technique [17].
• Potentiation of morphine hyperthermia in cats by pimozide and fluoxetine hydrochloride [18].
• Rats treated with Lilly 110140, a specific inhibitor of serotonin re-uptake in brain, are less sensitive to electroshock [19].

Biological context of Prozac

• Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac) [11].
• Molecular structure of fluoxetine hydrochloride, a highly selective serotonin-uptake inhibitor [20].
• The diary records showed increased crying, decreased sleep, increased vomiting, and watery stools when fluoxetine hydrochloride was transmitted through breast feeding or breast milk in bottle [5].
• METHODS: Males were treated daily with fluoxetine hydrochloride (0, 1, 5, or 10 mg/kg) and tested for sexual behavior with receptive females at 4-day intervals [21].
• Fluoxetine (Prozac) interaction with the mitochondrial voltage-dependent anion channel and protection against apoptotic cell death [22].

Anatomical context of Prozac

• We suggest a possible relationship between colic and associated symptoms and fluoxetine hydrochloride in maternal breast milk [5].
• The uptake of 5-HT into synaptosomes was significantly inhibited 15 minutes after an intraperitoneal administration of Lilly 110140 [23].
• The most common side effects of Prozac in adult patients involve primarily the central nervous system and include nervousness, tremor, jitteriness, and occasionally seizures [24].
• Previous studies showed that the serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine (Prozac) dilates skeletal muscle and cerebral arterioles independent of the endothelium [25].
• In cultured human epithelium, currents from calcium-activated potassium channels and inward rectifiers are unaffected by Prozac [26].

Associations of Prozac with other chemical compounds

• Furthermore, we demonstrate that CRABP-II is actually the CRABP previously studied in epidermal cells by a PAGE assay (Siegenthaler & Saurat (1987) Eur. J Biochem. 166, 209-214) and whose levels are dramatically increased by retinoic acid and its analogues in human epidermis [27].
• The present study suggests that Lilly 110140 is a potent and selective inhibitor for uptake of 5-HT into synaptosomes of rat brain [23].
• We assessed the contributions of fluoxetine (Prozac) and bumetanide-sensitive membrane ion transport pathways to such responses by determining K(+) efflux and influx [28].
• We studied the adsorption of fluoxetine HCl (Prozac) by Norit USP XXIII activated charcoal in vitro, in simulated gastric fluid (USP; pH 1.2), and in simulated intestinal fluid (USP; pH 7.5) [29].
• Traditional analytical techniques employing HPLC for potency, content uniformity, chromatographic purity and drug release profiles were used to evaluate the quality of five selected drug products (fluoxetine hydrochloride, levothyroxine sodium, metformin hydrochloride, phenytoin sodium, and warfarin sodium) [30].

Gene context of Prozac

• In rats weighing 120-170 g, the administration of fluoxetine (Lilly 110140), an inhibitor of serotonin uptake, produced a significant elevation of serum PRL which persisted for at least 8 h [31].
• Nineteen children and adolescents with attention-deficit hyperactivity disorder were treated with fluoxetine hydrochloride [32].
• These results provide evidence for a potential role of monoamine oxidase B inhibition in the therapeutic effects of Prozac [33].
• A selective serotonin reuptake inhibitor, fluoxetine hydrochloride, modulates the pulsatile release of prolactin in postmenopausal women [34].
• Freud, Prozac, and the human condition [35].

Analytical, diagnostic and therapeutic context of Prozac

• This study examines the efficacy of BT and fluoxetine hydrochloride compared with a waiting-list (WL) control group [36].
• We determined fluoxetine (Prozac) and its major metabolite norfluoxetine in plasma by liquid chromatography with fluorescence detection [37].
• The potential of nonaqueous capillary electrophoresis was investigated for the simultaneous separation of fluoxetine hydrochloride, its meta-isomer, and other related compounds [38].
• Using X-ray crystallography, we have determined the three-dimensional structure of fluoxetine hydrochloride [20].
• Cardiac metabolism, performance, and ultrastructure were measured in response to 1 hour of cardioplegic arrest in 15 pigs with right ventricular hypertrophy using intermittent hypothermic crystalloid, blood, and Flusol DA 20%-based cardioplegia [39].

References