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Gene Review

SCGN  -  secretagogin, EF-hand calcium binding protein

Homo sapiens

Synonyms: CALBL, DJ501N12.8, SECRET, SEGN, Secretagogin, ...
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Disease relevance of SCGN


Psychiatry related information on SCGN

  • OBJECTIVE: A recent review by the United States Secret Service of cases involving threats against the President indicated that about 50 percent of subjects had received mental health care [4].

High impact information on SCGN


Chemical compound and disease context of SCGN


Biological context of SCGN


Anatomical context of SCGN


Associations of SCGN with chemical compounds

  • Glucose also led to changes in expression of secretagogin protein in INS-1e cells, but not in primary cells from non-diabetes-prone Wistar Furth rats [9].
  • "The Delicious Progress": whiteness as an atavism in Conrad Aiken's "Silent Snow, Secret Snow" [10].
  • This paper is an extract from The Invisible Hospital and the Secret Garden--an Insider's Commentary on NHS Reforms and is based on a paper presented at The Royal Society of Medicine in London on 11 April 1994 [11].

Co-localisations of SCGN


Other interactions of SCGN

  • In addition to the most common genes (e.g. insulin, transthyretin, glucagon), a number of other abundant genes with ill-defined functions such as proSAAS or secretagogin, were also observed [12].
  • Delusional visitors to the White House or other government offices (often seeking a personal audience with the President) are interviewed by the Secret Service and then sent to Saint Elizabeths Hospital if they are considered mentally ill and potentially dangerous to themselves or others [13].
  • Ernest Jones, in particular, an analysand of Ferenczi and fellow member of the Secret Committee founded by Freud before World War I, seriously attacked Ferenczi [14].

Analytical, diagnostic and therapeutic context of SCGN


  1. Secretagogin, a novel neuroendocrine marker, has a distinct expression pattern from chromogranin A. Lai, M., Lü, B., Xing, X., Xu, E., Ren, G., Huang, Q. Virchows Arch. (2006) [Pubmed]
  2. Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein. Gartner, W., Lang, W., Leutmetzer, F., Domanovits, H., Waldhäusl, W., Wagner, L. Cereb. Cortex (2001) [Pubmed]
  3. Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. Zhan, X., Evans, C.O., Oyesiku, N.M., Desiderio, D.M. Pituitary (2003) [Pubmed]
  4. Mental health clinicians' attitudes about reporting threats against the president. Coggins, M.H., Steadman, H.J., Veysey, B.M. Psychiatric services (Washington, D.C.) (1996) [Pubmed]
  5. Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein. Wagner, L., Oliyarnyk, O., Gartner, W., Nowotny, P., Groeger, M., Kaserer, K., Waldhäusl, W., Pasternack, M.S. J. Biol. Chem. (2000) [Pubmed]
  6. Secretagogin is a new neuroendocrine marker in the human prostate. Adolf, K., Wagner, L., Bergh, A., Stattin, P., Ottosen, P., Borre, M., Birkenkamp-Demtröder, K., Orntoft, T.F., Tørring, N. Prostate (2007) [Pubmed]
  7. Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene. Zierhut, B., Daneva, T., Gartner, W., Brunnmaier, B., Mineva, I., Berggård, T., Wagner, L. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  8. Secretagogin is a novel marker for neuroendocrine differentiation. Birkenkamp-Demtröder, K., Wagner, L., Brandt Sørensen, F., Bording Astrup, L., Gartner, W., Scherübl, H., Heine, B., Christiansen, P., Ørntoft, T.F. Neuroendocrinology (2005) [Pubmed]
  9. Identification and characterization of secretagogin promoter activity. Skovhus, K.V., Bergholdt, R., Erichsen, C., Sparre, T., Nerup, J., Karlsen, A.E., Pociot, F. Scand. J. Immunol. (2006) [Pubmed]
  10. "The Delicious Progress": whiteness as an atavism in Conrad Aiken's "Silent Snow, Secret Snow". Lavery, D.L. Psychoanalytic review. (1983) [Pubmed]
  11. The invisible hospital--or, what patients experience but managers often don't see. Spiers, J. World hospitals and health services : the official journal of the International Hospital Federation. (1996) [Pubmed]
  12. An expression profile of human pancreatic islet mRNAs by Serial Analysis of Gene Expression (SAGE). Cras-Méneur, C., Inoue, H., Zhou, Y., Ohsugi, M., Bernal-Mizrachi, E., Pape, D., Clifton, S.W., Permutt, M.A. Diabetologia (2004) [Pubmed]
  13. White House Cases: psychiatric patients and the Secret Service. Shore, D., Filson, C.R., Davis, T.S., Olivos, G., DeLisi, L., Wyatt, R.J. The American journal of psychiatry. (1985) [Pubmed]
  14. Could Balint have done more for Ferenczi? Mészáros, J. American journal of psychoanalysis. (2003) [Pubmed]
  15. Identification of differentially expressed proteins in colorectal cancer by proteomics: down-regulation of secretagogin. Xing, X., Lai, M., Gartner, W., Xu, E., Huang, Q., Li, H., Chen, G. Proteomics (2006) [Pubmed]
  16. Analytical Methods Used for the Discrimination of Substances Suspected to be Bar Soap: A Preliminary Study. Arredondo, M., Laporte, G.M., Wilson, J.D., McConnell, T., Shaffer, D.K., Stam, M. J. Forensic Sci. (2006) [Pubmed]
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