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Gene Review

ENAH  -  enabled homolog (Drosophila)

Homo sapiens

Synonyms: ENA, FLJ10773, MENA, NDPP1, Protein enabled homolog
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Disease relevance of ENAH

  • PURPOSE: hMena (ENAH), a cytoskeleton regulatory protein involved in the regulation of cell motility and adhesion, is overexpressed in breast cancer [1].
  • In these cells, Shigella form normal-appearing actin tails and move at rates that are comparable to the rates of bacterial movement in Ena/VASP-deficient cells complemented with the Ena/VASP family member Mena [2].
  • The Mena EVH1 domain, a protein-interaction module involved in actin-based cell motility, recognizes proline-rich ligand motifs, which are also present in the sequence of the surface protein ActA of Listeria monocytogenes [3].
  • To examine the influence of age on the autonomic and electrophysiological correlates of sudden death after myocardial infarction, 223 patients aged less than 60 and 195 patients aged greater than or equal to 60 were followed up for a mena of 790 days [4].

High impact information on ENAH


Biological context of ENAH

  • By transfection assays we showed that zyxin interaction with Mena/VASP in vivo enhances the production of actin-rich structures at the apical surface of cells [9].
  • Structure-based synthetic mimicry of discontinuous protein binding sites: inhibitors of the interaction of Mena EVH1 domain with proline-rich ligands [3].
  • Based on the crystal structure of Mena EVH1 in complex with a polyproline peptide ligand, we have generated a range of assembled peptides presenting the Mena EVH1 fragments that make up its discontinuous binding site for proline-rich ligands [3].

Anatomical context of ENAH


Associations of ENAH with chemical compounds


Physical interactions of ENAH


Other interactions of ENAH


Analytical, diagnostic and therapeutic context of ENAH


  1. The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors. Di Modugno, F., Mottolese, M., Di Benedetto, A., Conidi, A., Novelli, F., Perracchio, L., Venturo, I., Botti, C., Jager, E., Santoni, A., Natali, P.G., Nisticò, P. Clin. Cancer Res. (2006) [Pubmed]
  2. Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Ally, S., Sauer, N.J., Loureiro, J.J., Snapper, S.B., Gertler, F.B., Goldberg, M.B. Cell. Microbiol. (2004) [Pubmed]
  3. Structure-based synthetic mimicry of discontinuous protein binding sites: inhibitors of the interaction of Mena EVH1 domain with proline-rich ligands. Hunke, C., Hirsch, T., Eichler, J. Chembiochem (2006) [Pubmed]
  4. The effect of age on the electrophysiological and autonomic correlates of sudden death after acute myocardial infarction. Odemuyiwa, O., Farrell, T., Malik, M., Bashir, Y., Poloniecki, J., Ward, D.E., Camm, A.J. Pacing and clinical electrophysiology : PACE. (1991) [Pubmed]
  5. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. Garvalov, B.K., Higgins, T.E., Sutherland, J.D., Zettl, M., Scaplehorn, N., Köcher, T., Piddini, E., Griffiths, G., Way, M. J. Cell Biol. (2003) [Pubmed]
  6. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. Sabo, S.L., Ikin, A.F., Buxbaum, J.D., Greengard, P. J. Cell Biol. (2001) [Pubmed]
  7. Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Di Modugno, F., DeMonte, L., Balsamo, M., Bronzi, G., Nicotra, M.R., Alessio, M., Jager, E., Condeelis, J.S., Santoni, A., Natali, P.G., Nisticò, P. Cancer Res. (2007) [Pubmed]
  8. The Rho family GTPase Rif induces filopodia through mDia2. Pellegrin, S., Mellor, H. Curr. Biol. (2005) [Pubmed]
  9. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. Drees, B., Friederich, E., Fradelizi, J., Louvard, D., Beckerle, M.C., Golsteyn, R.M. J. Biol. Chem. (2000) [Pubmed]
  10. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Krugmann, S., Jordens, I., Gevaert, K., Driessens, M., Vandekerckhove, J., Hall, A. Curr. Biol. (2001) [Pubmed]
  11. Ena/VASP proteins mediate repulsion from ephrin ligands. Evans, I.R., Renne, T., Gertler, F.B., Nobes, C.D. J. Cell. Sci. (2007) [Pubmed]
  12. Interactions of drebrin and gephyrin with profilin. Mammoto, A., Sasaki, T., Asakura, T., Hotta, I., Imamura, H., Takahashi, K., Matsuura, Y., Shirao, T., Takai, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Effects of angiotensin II blockade by saralasin in normal man. Noth, R.H., Tan, S.Y., Mulrow, P.J. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  14. A comparison of radiation-sensitizing ability and cell uptake for NDPP and Ro-07-0582. Wong, T.W., Whitmore, G.F. Radiat. Res. (1977) [Pubmed]
  15. Iatrogenic hyperosmolality in critically ill low-birth-weight infants. Horváth, M., Mestyán, I., Mestyán, J. Acta paediatrica Academiae Scientiarum Hungaricae. (1975) [Pubmed]
  16. Interleukin 1 alpha production by peripheral blood monocytes from patients with chronic liver disease and effect of sera on interleukin 1 alpha production. Kakumu, S., Tahara, H., Fuji, A., Yoshioka, K. Journal of clinical & laboratory immunology. (1988) [Pubmed]
  17. The state of the actin cytoskeleton determines its association with gephyrin: role of ena/VASP family members. Bausen, M., Fuhrmann, J.C., Betz, H., O'sullivan, G.A. Mol. Cell. Neurosci. (2006) [Pubmed]
  18. Myosin X transports Mena/VASP to the tip of filopodia. Tokuo, H., Ikebe, M. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  19. N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. Nakagawa, H., Miki, H., Ito, M., Ohashi, K., Takenawa, T., Miyamoto, S. J. Cell. Sci. (2001) [Pubmed]
  20. Detection of binding partners to the profilin:actin complex by far Western and mass spectrometry analyses. Johansson, T., Grenklo, S., Karlsson, R. Anal. Biochem. (2004) [Pubmed]
  21. Causes of hospitalization of pilgrims in the Hajj season of the Islamic year 1423 (2003). Madani, T.A., Ghabrah, T., Al-Hedaithy, M., Alhazmi, M., Alazraqi, T., Albarrak, A., Ishaq, A.H. Annals of Saudi medicine. (2006) [Pubmed]
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