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Gene Review

SLC25A19  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: DNC, MCPHA, MUP1, Mitochondrial thiamine pyrophosphate carrier, Mitochondrial uncoupling protein 1, ...
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Disease relevance of SLC25A19


High impact information on SLC25A19


Chemical compound and disease context of SLC25A19


Biological context of SLC25A19


Anatomical context of SLC25A19

  • The deoxynucleotide carrier (DNC) transports deoxynucleotides into mitochondria and is therefore essential for mtDNA synthesis [12].
  • We investigated whether high plasma FFAs increase mitochondrial uncoupling protein (UCP) levels in the mouse heart by activating the nuclear transcription factor peroxisome proliferator-activated receptor (PPAR)alpha [17].
  • A large number of studies have established the mitochondrial uncoupling protein UCP1 as a specific marker of brown adipocytes, where it controls energy dissipation of fatty acid oxidation as heat in response to physiological requirements [18].
  • Pelvic floor muscle strength was defined at "holding" UPP by the maximum urethral pressure developed during attempts "to hold urine" (hMUP) [19].
  • The DNI, DNM and DNC descending interneurons all have very similar properties and are each at the convergence of visual, ocellar, wind-hair and other mechanoreceptor inputs [20].

Associations of SLC25A19 with chemical compounds


Other interactions of SLC25A19


Analytical, diagnostic and therapeutic context of SLC25A19


  1. The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals. Dolce, V., Fiermonte, G., Runswick, M.J., Palmieri, F., Walker, J.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis coli, and de novo cancer. Greenstein, A.J., Slater, G., Heimann, T.M., Sachar, D.B., Aufses, A.H. Ann. Surg. (1986) [Pubmed]
  3. Role of energy charge and AMP-activated protein kinase in adipocytes in the control of body fat stores. Rossmeisl, M., Flachs, P., Brauner, P., Sponarova, J., Matejkova, O., Prazak, T., Ruzickova, J., Bardova, K., Kuda, O., Kopecky, J. Int. J. Obes. Relat. Metab. Disord. (2004) [Pubmed]
  4. Sensitivity to the weed killer DNA-nitralin and cross-sensitivity to dinitrochlorobenzene. Nishioka, K., Asagami, C., Kurata, M., Fujita, H. Archives of dermatology. (1983) [Pubmed]
  5. Mitochondrial proteins in neuronal degeneration. Lindholm, D., Eriksson, O., Korhonen, L. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Mutant deoxynucleotide carrier is associated with congenital microcephaly. Rosenberg, M.J., Agarwala, R., Bouffard, G., Davis, J., Fiermonte, G., Hilliard, M.S., Koch, T., Kalikin, L.M., Makalowska, I., Morton, D.H., Petty, E.M., Weber, J.L., Palmieri, F., Kelley, R.I., Schäffer, A.A., Biesecker, L.G. Nat. Genet. (2002) [Pubmed]
  7. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. Fisher, M.H., Amend, A.M., Bach, T.J., Barker, J.M., Brady, E.J., Candelore, M.R., Carroll, D., Cascieri, M.A., Chiu, S.H., Deng, L., Forrest, M.J., Hegarty-Friscino, B., Guan, X.M., Hom, G.J., Hutchins, J.E., Kelly, L.J., Mathvink, R.J., Metzger, J.M., Miller, R.R., Ok, H.O., Parmee, E.R., Saperstein, R., Strader, C.D., Stearns, R.A., MacIntyre, D.E. J. Clin. Invest. (1998) [Pubmed]
  8. Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Lindhurst, M.J., Fiermonte, G., Song, S., Struys, E., De Leonardis, F., Schwartzberg, P.L., Chen, A., Castegna, A., Verhoeven, N., Mathews, C.K., Palmieri, F., Biesecker, L.G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Mitochondrial uncoupling protein is required for efficient photosynthesis. Sweetlove, L.J., Lytovchenko, A., Morgan, M., Nunes-Nesi, A., Taylor, N.L., Baxter, C.J., Eickmeier, I., Fernie, A.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Sullivan, P.G., Dubé, C., Dorenbos, K., Steward, O., Baram, T.Z. Ann. Neurol. (2003) [Pubmed]
  11. Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation. Klaus, S., Rudolph, B., Dohrmann, C., Wehr, R. Physiol. Genomics (2005) [Pubmed]
  12. Genomic organization and mapping of the gene (SLC25A19) encoding the human mitochondrial deoxynucleotide carrier (DNC). Iacobazzi, V., Ventura, M., Fiermonte, G., Prezioso, G., Rocchi, M., Palmieri, F. Cytogenet. Cell Genet. (2001) [Pubmed]
  13. Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene. Rim, J.S., Kozak, L.P. J. Biol. Chem. (2002) [Pubmed]
  14. Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake. Lam, W., Chen, C., Ruan, S., Leung, C.H., Cheng, Y.C. Mol. Pharmacol. (2005) [Pubmed]
  15. Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. Oberkofler, H., Dallinger, G., Liu, Y.M., Hell, E., Krempler, F., Patsch, W. J. Lipid Res. (1997) [Pubmed]
  16. Fatty acid binding site of the mitochondrial uncoupling protein. Demonstration of its existence by EPR spectroscopy of 5-DOXYL-stearic acid. Jezek, P., Freisleben, H.J. FEBS Lett. (1994) [Pubmed]
  17. Plasma Free Fatty Acids and Peroxisome Proliferator-Activated Receptor {alpha} in the Control of Myocardial Uncoupling Protein Levels. Murray, A.J., Panagia, M., Hauton, D., Gibbons, G.F., Clarke, K. Diabetes (2005) [Pubmed]
  18. Thymus uncoupling protein 1 is exclusive to typical brown adipocytes and is not found in thymocytes. Frontini, A., Rousset, S., Cassard-Doulcier, A.M., Zingaretti, C., Ricquier, D., Cinti, S. J. Histochem. Cytochem. (2007) [Pubmed]
  19. Urgency of voiding and abdominal pressure transmission in women with mixed urinary incontinence. Cucchi, A., Siracusano, S., Di Benedetto, P., Comelli, M., Rovereto, B. Neurourology and urodynamics. (2004) [Pubmed]
  20. Three descending interneurons reporting deviation from course in the locust. II. Physiology. Rowell, C.H., Reichert, H. J. Comp. Physiol. A (1986) [Pubmed]
  21. High expression of leptin by human bone marrow adipocytes in primary culture. Laharrague, P., Larrouy, D., Fontanilles, A.M., Truel, N., Campfield, A., Tenenbaum, R., Galitzky, J., Corberand, J.X., Pénicaud, L., Casteilla, L. FASEB J. (1998) [Pubmed]
  22. Regulation of the uncoupling protein in brown adipose tissue. LaNoue, K.F., Strzelecki, T., Strzelecka, D., Koch, C. J. Biol. Chem. (1986) [Pubmed]
  23. Inhibition of 5'-deiodination of thyroxine suppresses the cold-induced increase in brown adipose tissue messenger ribonucleic acid for mitochondrial uncoupling protein without influencing lipoprotein lipase activity. Reiter, R.J., Klaus, S., Ebbinghaus, C., Heldmaier, G., Redlin, U., Ricquier, D., Vaughan, M.K., Steinlechner, S. Endocrinology (1990) [Pubmed]
  24. Mutation analysis in 16 patients with mtDNA depletion. Carrozzo, R., Bornstein, B., Lucioli, S., Campos, Y., de la Pena, P., Petit, N., Dionisi-Vici, C., Vilarinho, L., Rizza, T., Bertini, E., Garesse, R., Santorelli, F.M., Arenas, J. Hum. Mutat. (2003) [Pubmed]
  25. Mitochondrial uncoupling protein 3 (UCP3) in skeletal muscle. Tsuboyama-Kasaoka, N., Ezaki, O. Front. Biosci. (2001) [Pubmed]
  26. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. Yu, X.X., Mao, W., Zhong, A., Schow, P., Brush, J., Sherwood, S.W., Adams, S.H., Pan, G. FASEB J. (2000) [Pubmed]
  27. Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects. Nordfors, L., Hoffstedt, J., Nyberg, B., Thörne, A., Arner, P., Schalling, M., Lönnqvist, F. Diabetologia (1998) [Pubmed]
  28. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Diano, S., Matthews, R.T., Patrylo, P., Yang, L., Beal, M.F., Barnstable, C.J., Horvath, T.L. Endocrinology (2003) [Pubmed]
  29. Selective labelling of melittin with a fluorescent dansylcadaverine probe using guinea-pig liver transglutaminase. Pérez-Payá, E., Thiaudière, E., Abad, C., Dufourcq, J. FEBS Lett. (1991) [Pubmed]
  30. The influence of nutritional status on skin anergy in experimental cancer. Waitzberg, D., Gonçalves, E., da Silva Duarte, A., Faintuch, J., Rocha, C., Bevilacqua, L. Clinical nutrition (Edinburgh, Scotland) (1989) [Pubmed]
  31. Liquid chromatographic determination of nicarbazin in feeds and premixes. Macy, T.D., Loh, A. Journal - Association of Official Analytical Chemists. (1984) [Pubmed]
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