Gene Review:
SLC6A12 - solute carrier family 6 (neurotransmitter...
Homo sapiens
Synonyms:
BGT-1, BGT1, GAT2, Na(+)/Cl(-) betaine/GABA transporter, Sodium-and chloride-dependent betaine transporter, ...
- Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition. Ruiz-Tachiquín, M.E., Sánchez-Lemus, E., Soria-Jasso, L.E., Arias-Montaño, J.A., Ortega, A. J. Neurosci. Res. (2002)
- ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP. Irarrazabal, C.E., Liu, J.C., Burg, M.B., Ferraris, J.D. Proc. Natl. Acad. Sci. U.S.A. (2004)
- TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc. Tsai, T.T., Danielson, K.G., Guttapalli, A., Oguz, E., Albert, T.J., Shapiro, I.M., Risbud, M.V. J. Biol. Chem. (2006)
- Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. Nadkarni, V., Gabbay, K.H., Bohren, K.M., Sheikh-Hamad, D. J. Biol. Chem. (1999)
- Mitochondrial reactive oxygen species contribute to high NaCl-induced activation of the transcription factor TonEBP/OREBP. Zhou, X., Ferraris, J.D., Burg, M.B. Am. J. Physiol. Renal Physiol. (2006)
- Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney. Rasola, A., Galietta, L.J., Barone, V., Romeo, G., Bagnasco, S. FEBS Lett. (1995)
- Osmolyte strategy in human monocytes and macrophages: involvement of p38MAPK in hyperosmotic induction of betaine and myoinositol transporters. Denkert, C., Warskulat, U., Hensel, F., Häussinger, D. Arch. Biochem. Biophys. (1998)
- Osmotic regulation of renal betaine transport: transcription and beyond. Kempson, S.A., Montrose, M.H. Pflugers Arch. (2004)
- Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts. Fujimori, S., Hinoi, E., Takarada, T., Iemata, M., Takahata, Y., Yoneda, Y. Eur. J. Pharmacol. (2006)
- A light and electron microscopic study of betaine/GABA transporter distribution in the monkey cerebral neocortex and hippocampus. Zhu, X.M., Ong, W.Y. J. Neurocytol. (2004)
- Cloning and expression of a betaine/GABA transporter from human brain. Borden, L.A., Smith, K.E., Gustafson, E.L., Branchek, T.A., Weinshank, R.L. J. Neurochem. (1995)
- GABA and glutamate transporters are expressed in human platelets. Rainesalo, S., Keränen, T., Saransaari, P., Honkaniemi, J. Brain Res. Mol. Brain Res. (2005)
- Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity. Miyakawa, H., Woo, S.K., Chen, C.P., Dahl, S.C., Handler, J.S., Kwon, H.M. Am. J. Physiol. (1998)
- Conditionally immortalized syncytiotrophoblast cell lines as new tools for study of the blood-placenta barrier. Kitano, T., Iizasa, H., Hwang, I.W., Hirose, Y., Morita, T., Maeda, T., Nakashima, E. Biol. Pharm. Bull. (2004)
- Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy. Schousboe, A., Larsson, O.M., Sarup, A., White, H.S. Eur. J. Pharmacol. (2004)
- Response of human cells to desiccation: comparison with hyperosmotic stress response. Huang, Z., Tunnacliffe, A. J. Physiol. (Lond.) (2004)