The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HLTF  -  helicase-like transcription factor

Homo sapiens

Synonyms: DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, HIP116A, HLTF1, Helicase-like transcription factor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HLTF


High impact information on HLTF


Chemical compound and disease context of HLTF


Biological context of HLTF

  • Two Sp1 sites that are also conserved in the putative promoter of human SMARCA3 and a RUSH binding site (-616/-611) that is unique to the rabbit promoter repress basal transcription [5].
  • HLTF gene silencing in human colon cancer [1].
  • Mutations affecting either the Sp1/Sp3 or the two HLTF sites inhibited by 6- and 2.5-fold, respectively, transient expression in HeLa cells of a reporter gene fused to the PAI-1 promoter [6].
  • Here we report the characterization of the Zbu1 gene, also known as HIP116, located on human chromosome band 3q25, which encodes a DNA-binding member of this superfamily [7].
  • The developmental profile of Zbu1 gene expression and the association of the protein with a tissue-specific transcriptional regulatory element distinguish it from other members of the SWI2/SNF2 family and suggest novel roles for the Zbu1 gene product [7].

Anatomical context of HLTF


Associations of HLTF with chemical compounds


Physical interactions of HLTF


Regulatory relationships of HLTF


Other interactions of HLTF


Analytical, diagnostic and therapeutic context of HLTF

  • Electrophoretic mobility shift assays performed on a set of B box point mutants demonstrated two HLTF sites flanking and partially overlapping with a GT box binding Sp1 and Sp3 [6].
  • Expression of HLTF was examined by reverse-transcription (RT)-polymerase chain reaction (PCR), and promoter hypermethylation in HLTF was determined by methylation-specific PCR [3].
  • Sequence analysis indicates that the P113 is highly homologous to HIP116/HLTF (human) and RUSH-1alpha (rabbit) [12].
  • HLTF expression was conserved in the HKT-1097 cell line established from kidney tumors, but again only 10% of positive cells were found in xenografts produced by HKT-1097 cells in nude mice [11].


  1. HLTF gene silencing in human colon cancer. Moinova, H.R., Chen, W.D., Shen, L., Smiraglia, D., Olechnowicz, J., Ravi, L., Kasturi, L., Myeroff, L., Plass, C., Parsons, R., Minna, J., Willson, J.K., Green, S.B., Issa, J.P., Markowitz, S.D. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter. Sheridan, P.L., Schorpp, M., Voz, M.L., Jones, K.A. J. Biol. Chem. (1995) [Pubmed]
  3. Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer. Leung, W.K., Yu, J., Bai, A.H., Chan, M.W., Chan, K.K., To, K.F., Chan, F.K., Ng, E.K., Chung, S.C., Sung, J.J. Mol. Carcinog. (2003) [Pubmed]
  4. DNA-dependent adenosine triphosphatase (helicaselike transcription factor) activates beta-globin transcription in K562 cells. Mahajan, M.C., Weissman, S.M. Blood (2002) [Pubmed]
  5. An Sp1-NF-Y/progesterone receptor DNA binding-dependent mechanism regulates progesterone-induced transcriptional activation of the rabbit RUSH/SMARCA3 gene. Hewetson, A., Chilton, B.S. J. Biol. Chem. (2003) [Pubmed]
  6. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. Ding, H., Benotmane, A.M., Suske, G., Collen, D., Belayew, A. J. Biol. Chem. (1999) [Pubmed]
  7. Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. Gong, X., Kaushal, S., Ceccarelli, E., Bogdanova, N., Neville, C., Nguyen, T., Clark, H., Khatib, Z.A., Valentine, M., Look, A.T., Rosenthal, N. Dev. Biol. (1997) [Pubmed]
  8. Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene. Ding, H., Descheemaeker, K., Marynen, P., Nelles, L., Carvalho, T., Carmo-Fonseca, M., Collen, D., Belayew, A. DNA Cell Biol. (1996) [Pubmed]
  9. Methylation pattern of HLTF gene in digestive tract cancers. Hibi, K., Nakayama, H., Kanyama, Y., Kodera, Y., Ito, K., Akiyama, S., Nakao, A. Int. J. Cancer (2003) [Pubmed]
  10. Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis. Hibi, K., Kodera, Y., Ito, K., Akiyama, S., Nakao, A. Dis. Colon Rectum (2005) [Pubmed]
  11. Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis. Debauve, G., Nonclercq, D., Ribaucour, F., Wiedig, M., Gerbaux, C., Leo, O., Laurent, G., Journé, F., Belayew, A., Toubeau, G. Mol. Cancer (2006) [Pubmed]
  12. Molecular cloning and characterization of P113, a mouse SNF2/SWI2-related transcription factor. Zhang, Q., Ekhterae, D., Kim, K.H. Gene (1997) [Pubmed]
WikiGenes - Universities