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Gene Review

SSAV1  -  simian sarcoma-associated virus 1/gibbon...

Homo sapiens

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Disease relevance of SSAV1


High impact information on SSAV1

  • Cell cultures established from a marmoset fibroma produced transforming and nontransforming virus biologically and antigenically indistinguishable from HL-23V and SSV-1/SSAV-1 [4].
  • Comparative sequence analysis of SSV and SSAV showed that SSAV provides regulatory sequences for initiation and termination of transcription of the SSV transforming gene [5].
  • Moreover, coding sequences for the putative protein product of this gene appear to initiate from the amino terminus of the SSAV env gene [5].
  • A 675-nucleotide-long open reading frame commenced 19 nucleotides within the SSAV sequences to the left of the v-sis helper viral junction and terminated within v-sis itself [6].
  • The cloned 9-kilobase SSAV genome (B11) has the same restriction map as the bulk of the unintegrated linear SSAV DNA intermediate [7].

Chemical compound and disease context of SSAV1


Biological context of SSAV1


Anatomical context of SSAV1

  • This study reports the immunohistologic detection of SSAV/GaLV type C retrovirus p30-related antigen in unfixed cryostat sections of normal human term placentas by the indirect immunofluorescence method [14].
  • A nonconditional transformation-defective virus, designated td26-SM-FeSV (SSAV), was isolated from one of the cell lines [12].
  • Most of these sequences have been found to be related to primate and murine C-type viruses (BaEV, SSAV/GaLV, MuLV), murine B-type viruses and A-type particles (MMTV, IAP), or human T-cell lymphotropic viruses (HTLV) [15].
  • Like SSAV and GALV, HEL-12 virus induced syncytia with XC cells [16].
  • Fibroblast cell lines infected in vitro with different strains of gibbon ape leukaemia virus or the related woolly monkey virus (SSAV) synthesized two RNA species of approximately 8.4 kb and 2.9 kb [17].

Associations of SSAV1 with chemical compounds

  • Cells infected with td26-SM-FeSV (SSAV) synthesized a gag-fms fusion glycoprotein (gp180gag-fms) [12].

Other interactions of SSAV1

  • One molecular clone, termed S71, contains sequences related to the genes coding for the group-specific antigens (gag) and polymerase (pol) proteins of SSAV [18].

Analytical, diagnostic and therapeutic context of SSAV1

  • Heteroduplex analysis between an SSV clone (lambda-C60) and an SSAV clone (lambda-B11) showed two substitution loops and one deletion loop [7].
  • As shown by immunoblotting analysis, the main reactive antigen recognized by anti-BAST was a non-glycosylated 32-kDa placental protein which was antigenically related to SSAV p30 [19].
  • Western blot analysis of the bone marrow plasma of both patients with ALL-HMV showed an increase of cross-reactive IgG to the envelope gp70 and IgM against the core p30 proteins of the baboon endogenous virus (BaEV) and simian sarcoma-associated virus (SSAV) [20].
  • The RNA virus-based transfection system requires electroporation of in vitro transcribed RNA into GLV-infected trophozoites [21].
  • Antibodies cross-reactive with type C viral p30 were concentrated from 105 samples of human plasma by affinity chromatography using Sepharose beads to which disrupted Simian sarcoma associated virus (SSAV) had been coupled [22].


  1. Assignment of the human endogenous retrovirus S71 (SSAV1) to chromosome 18 band q12.3 by radiation hybrid mapping. Kim, H.S., Crow, T.J. Cytogenet. Cell Genet. (1998) [Pubmed]
  2. A pseudoautosomal boundary-like element adjacent to the SSAV1 locus at 18q21. Blusch, J.H., Brack-Werner, R., Werner, T. DNA Seq. (1999) [Pubmed]
  3. Specific binding of the type C viral core protein p12 with purified viral RNA. Sen, A., Sherr, C.J., Todaro, G.J. Cell (1976) [Pubmed]
  4. Oncogenicity in marmosets of HL-23V, a type C oncornavirus isolated from human leukemic cells, and comparison with simian sarcoma virus type 1 (SSV-1/SSAV-1). Bergholz, C.M., Wolfe, L.G., Deinhardt, F., Thakkar, B., Marczynska, B. J. Natl. Cancer Inst. (1977) [Pubmed]
  5. Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Devare, S.G., Reddy, E.P., Law, J.D., Robbins, K.C., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  6. Nucleotide sequence of the transforming gene of simian sarcoma virus. Devare, S.G., Reddy, E.P., Robbins, K.C., Andersen, P.R., Tronick, S.R., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  7. Molecular cloning and comparative analyses of the genomes of simian sarcoma virus and its associated helper virus. Gelmann, E.P., Wong-Staal, F., Kramer, R.A., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  8. Characterization of a virus-specific proteolytic activity processing the gag precursor of the simian sarcoma-associated virus. Kräusslich, H.G., Von der Helm, K. Virology (1987) [Pubmed]
  9. Isolation of the major glycoprotein (gp 70) of simian sarcoma virus (SSV-1/SSAV-1) in preparative quantities. Thiel, H.J., Bergholz, C., Geug, H., Deinhardt, F., Schwarz, H., Schäfer, W. Z. Naturforsch., C, Biosci. (1977) [Pubmed]
  10. Lower frequency of allele loss on chromosome 18q in human breast cancer than in colorectal tumors. Schenk, M., Leib-Mösch, C., Schenck, I.U., Jaenicke, M., Indraccolo, S., Saeger, H.D., Dallenbach-Hellweg, G., Hehlmann, R. J. Mol. Med. (1996) [Pubmed]
  11. Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Robbins, K.C., Devare, S.G., Aaronson, S.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  12. Isolation of a transformation-defective mutant of the McDonough strain of feline sarcoma virus exhibiting tyrosine kinase activity in vitro but not in vivo. Tamura, T., Hennig, D., Grell, M., Niemann, H., Boschek, B. J. Virol. (1988) [Pubmed]
  13. Deletions of specific regions of the simian sarcoma-associated virus genome are found in defective viruses and in the simian sarcoma virus. Gelmann, E.P., Petri, E., Cetta, A., Wong-Staal, F. J. Virol. (1982) [Pubmed]
  14. Immunohistologic detection of antigen related to primate type C retrovirus p30 in normal human placentas. Maeda, S., Mellors, R.C., Mellors, J.W., Jerabek, L.B., Zervoudakis, I.A. Am. J. Pathol. (1983) [Pubmed]
  15. Expression and biological significance of human endogenous retroviral sequences. Leib-Mösch, C., Bachmann, M., Brack-Werner, R., Werner, T., Erfle, V., Hehlmann, R. Leukemia (1992) [Pubmed]
  16. Biological and antigenic characteristics of HEL-12 virus. Bergholz, C.M., Reynolds, J.T., Panem, S. J. Gen. Virol. (1980) [Pubmed]
  17. Gibbon ape leukaemia virus RNA in leukaemic T-lymphoid cell lines: expression of a novel RNA transcript. Eiden, M., Trainor, C.D., Reitz, M.S. J. Gen. Virol. (1986) [Pubmed]
  18. Human SSAV-related endogenous retroviral element: LTR-like sequence and chromosomal localization to 18q21. Brack-Werner, R., Barton, D.E., Werner, T., Foellmer, B.E., Leib-Mösch, C., Francke, U., Erfle, V., Hehlmann, R. Genomics (1989) [Pubmed]
  19. Leukemia serum reactive with retrovirus-related antigen in normal human placenta. Maeda, S., Yonezawa, K., Yoshizaki, H., Mori, M., Kobayashi, T., Akahonai, Y., Yachi, A., Mellors, R.C. Int. J. Cancer (1986) [Pubmed]
  20. Acute lymphoblastic leukemia-hand mirror variant. Analysis for endogenous retroviral antibodies in bone marrow plasma. Schumacher, H.R., Desai, S.N., McClain, K.L., Domenico, D.R., Dizikes, G.J., Bird, M.L. Am. J. Clin. Pathol. (1989) [Pubmed]
  21. Genetic manipulation of Giardia lamblia. Davis-Hayman, S.R., Nash, T.E. Mol. Biochem. Parasitol. (2002) [Pubmed]
  22. Natural antibodies in human sera cross-reactive with type C RNA tumor viral P 30. Herbrink, P., van Bussel, F.J., Warnaar, S.O. Anticancer Res. (1982) [Pubmed]
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