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Gene Review

ELOVL6  -  ELOVL fatty acid elongase 6

Homo sapiens

Synonyms: 3-keto acyl-CoA synthase ELOVL6, ELOVL FA elongase 6, Elongation of very long chain fatty acids protein 6, FACE, FAE, ...
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Disease relevance of ELOVL6


High impact information on ELOVL6

  • The deduced amino acid sequence shows moderate levels of identity to medaka HCE1 (52.5%), medaka LCE (50.7%), crayfish astacin (33.2%), murine meprin-alpha (34%), and murine meprin-beta (33.5%), all members of the astacin family of zinc endopeptidases [6].
  • Suppression of Elovl-6 and Delta(9)D expression in livers of streptozotocin-induced diabetic rats and high fat-fed glucose-intolerant mice correlated with low levels of nuclear SREBP-1 [7].
  • In addition, Southern blot analysis showed that the genomic DNA of LCE, HeLa, and normal human leukocyte cells had a DNA rearrangement of the Quox-1 gene, suggesting that the rearrangement of genomic DNA might be the cause of differential expression in normal human tissues and tumor tissues [8].
  • Marked expression of Quox-1 was detected in early human embryos, LCE cells, and HeLa cells, with weak to zero expression being detected in various normal human tissues [8].
  • Also the expression of CD23 on B cells was higher after CCE than LCE (+146% versus +63%; P < 0.01) [1].

Biological context of ELOVL6

  • The Th1 response, characterized by phytohemagglutinin-induced IFN-gamma secretion in peripheral blood mononuclear cells and up-regulation of human leukocyte antigen-DR expression on monocytes, was lower after CCE than after LCE [1].
  • Stroke volume was similar between hybrid exercise and FES-LCE alone, and these two exercise modes evoked a significantly higher SV (by 41-56 percent) than during ACE alone [9].
  • Effects of FAE on intracellular cytokine profiles, T-cell apoptosis, and soluble adhesion molecules were also assessed [3].
  • These data clearly demonstrate that hybrid exercise creates a higher aerobic metabolic demand and cardiac-volume load in SCI quadriplegics than either subpeak levels of ACE or FES-LCE performed separately [9].
  • Compared with pretraining, this SCI group exhibited significantly (p less than or equal to .05) higher posttraining peak PO (+45%), oxygen uptake ([O2], + 23%), pulmonary ventilation (+27%), heart rate (+11%), cardiac output ([Qt], + 13%) and significantly lower total peripheral resistance ([TPR], - 14%) during FES-LCE posttests [4].

Anatomical context of ELOVL6

  • The purpose of this study was to assess the physiologic training effects of functional electrical stimulation leg cycle ergometer (FES-LCE) exercise in persons with spinal cord injury (SCI) who were previously untrained in this activity [4].
  • Each subject completed discontinuous graded FES-LCE and arm crank ergometer (ACE) tests before and after training for determinations of peak lower and upper extremity metabolic, pulmonary, and hemodynamic responses [4].
  • CONCLUSION: FES-LCE training can change the physiological properties of the quadriceps muscle in people with SCI [10].
  • Four groups of eight teeth each were cut to expose planar dentin sections and treated with (a) light-cure system with acetone as solvent (LCA group); (b) light-cure system with ethanol as solvent (LCE group); (c) dual-cure system with acetone as solvent (DCA group); and (d) dual-cure system with ethanol as solvent (DCE group) [11].

Associations of ELOVL6 with chemical compounds

  • FAE produced significant reductions from baseline in number (P < 0.05) and volume (P < 0.01) of Gd+ lesions after 18 weeks of treatment; this effect persisted during the second treatment phase at half the target dose after the 4-week washout period [3].
  • LCE, with or without other antiparkinsonian medications, was compared to UK standard care, comprising traditional levodopa/ dopa-decarboxylase inhibitor (DDCI) with other antiparkinsonian medications (e.g. selegiline or dopamine agonists) added as needed [12].

Analytical, diagnostic and therapeutic context of ELOVL6

  • The sensitivity of this approach was evaluated by comparing laparoscopic and conventional cholecystectomy (LCE, CCE) [1].
  • Functional electrical stimulation-induced leg cycle ergometry (FES-LCE) provides therapeutic exercise for persons with spinal cord injury (SCI) [13].
  • SETTINGS: The Sint Maartenskliniek rehabilitation centre and the University of Nijmegen, Nijmegen, the Netherlands. METHODS: Contractile properties of the quadriceps muscle were studied in seven people with motor-complete SCI who participated in a FES-LCE training program [10].


  1. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Decker, D., Schondorf, M., Bidlingmaier, F., Hirner, A., von Ruecker, A.A. Surgery (1996) [Pubmed]
  2. Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels. Müller, T., Erdmann, C., Muhlack, S., Bremen, D., Przuntek, H., Woitalla, D. Mov. Disord. (2006) [Pubmed]
  3. Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot study. Schimrigk, S., Brune, N., Hellwig, K., Lukas, C., Bellenberg, B., Rieks, M., Hoffmann, V., Pöhlau, D., Przuntek, H. Eur. J. Neurol. (2006) [Pubmed]
  4. Physiologic effects of electrical stimulation leg cycle exercise training in spinal cord injured persons. Hooker, S.P., Figoni, S.F., Rodgers, M.M., Glaser, R.M., Mathews, T., Suryaprasad, A.G., Gupta, S.C. Archives of physical medicine and rehabilitation. (1992) [Pubmed]
  5. Treatment of therapy-resistant Alopecia areata with fumaric acid esters. Venten, I., Hess, N., Hirschmüller, A., Altmeyer, P., Brockmeyer, N. Eur. J. Med. Res. (2006) [Pubmed]
  6. Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the astacin family. Hung, C.H., Huang, H.R., Huang, C.J., Huang, F.L., Chang, G.D. J. Biol. Chem. (1997) [Pubmed]
  7. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. Wang, Y., Botolin, D., Xu, J., Christian, B., Mitchell, E., Jayaprakasam, B., Nair, M., Peters, J.M., Busik, J., Olson, L.K., Jump, D.B. J. Lipid Res. (2006) [Pubmed]
  8. Differential expression of the Quox-1 gene in normal human cells, early human embryo, and tumor cells. Zhu, F., Li, W.X., Jiang, D.H., Gou, D.M. Cell Tissue Res. (2002) [Pubmed]
  9. Metabolic and hemodynamic responses to concurrent voluntary arm crank and electrical stimulation leg cycle exercise in quadriplegics. Hooker, S.P., Figoni, S.F., Rodgers, M.M., Glaser, R.M., Mathews, T., Suryaprasad, A.G., Gupta, S.C. Journal of rehabilitation research and development. (1992) [Pubmed]
  10. Altered contractile properties of the quadriceps muscle in people with spinal cord injury following functional electrical stimulated cycle training. Gerrits, H.L., de Haan, A., Sargeant, A.J., Dallmeijer, A., Hopman, M.T. Spinal Cord (2000) [Pubmed]
  11. Effect of primer solvent and curing mode on dentin shear bond strength and interface morphology. Velazquez, E., Vaidyanathan, J., Vaidyanathan, T.K., Houpt, M., Shey, Z., Von Hagen, S. Quintessence international. (2003) [Pubmed]
  12. Cost-effectiveness of levodopa/carbidopa/entacapone (Stalevo) compared to standard care in UK Parkinson's disease patients with wearing-off. Findley, L.J., Lees, A., Apajasalo, M., Pitkänen, A., Turunen, H. Current medical research and opinion. (2005) [Pubmed]
  13. Identifying offline muscle strength profiles sufficient for short-duration fes-lce exercise: a pac learning model approach. Trumbower, R.D., Karan, S.R., Faghri, P.D. Journal of clinical monitoring and computing. (2006) [Pubmed]
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