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Gene Review

Tuba1a  -  tubulin, alpha 1A

Rattus norvegicus

Synonyms: Alpha-tubulin 1, Tuba1, Tubulin alpha-1 chain, Tubulin alpha-1A chain
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Disease relevance of Tuba1


Psychiatry related information on Tuba1


High impact information on Tuba1


Biological context of Tuba1


Anatomical context of Tuba1


Associations of Tuba1 with chemical compounds


Physical interactions of Tuba1

  • Calponin interacts with both the alpha and beta tubulins and only slightly with the tyrosinated and acetylated form of alpha tubulin [22].

Regulatory relationships of Tuba1


Other interactions of Tuba1

  • In addition, there is a distinct tau-binding site at the amino-terminal region of alpha-tubulin. tau factors but not MAP2 displayed strong interaction with a peptide derived from the amino-terminal domain of alpha-tubulin between positions 1 and 75 [24].
  • The chemical cross-linked products of calponin and synthesized peptides (KDYEEVGVDSVEGE; alpha-KE) derived from the C-terminal region of alpha tubulin and (YQQYQDATADEQG; beta-YG) and (GEFEEEGEEDEA; beta-GA) from that of beta tubulin were detected by mass spectrometry [22].
  • In contrast, following bFGF treatment the distributions of tyrosinated and acetylated alpha-tubulin were identical, a state associated with a diminution of microtubule dynamics [25].
  • Double immunofluorescence for GAP-43, a marker for growth cones, and alpha-tubulin, a marker for axonal microtubules, showed that MMP-9-treated cells had increased distribution of alpha-tubulin but no effect on GAP-43 [26].
  • In addition to enumerating these S-nitrosylation sites, the method revealed endogenous SNO-Cys modification sites on cerebellum proteins, including alpha-tubulin, beta-tubulin, GAPDH, and dihydropyrimidinase-related protein-2 [27].

Analytical, diagnostic and therapeutic context of Tuba1


  1. Acetylation of alpha-tubulin in cultured neurons and the induction of alpha-tubulin acetylation in PC12 cells by treatment with nerve growth factor. Black, M.M., Keyser, P. J. Neurosci. (1987) [Pubmed]
  2. Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism. Gardini, G., Cravanzola, C., Autelli, R., Testore, G., Cesa, R., Morando, L., Solinas, S.P., Muzio, G., Grillo, M.A., Colombatto, S. J. Hepatol. (2003) [Pubmed]
  3. Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2. Osicka, T.M., Russo, L.M., Qiu, M.L., Brammar, G.C., Thallas, V., Forbes, J.M., Comper, W.D., Jerums, G. J. Hypertens. (2003) [Pubmed]
  4. Gene expression in the developing cerebellum during perinatal hypo- and hyperthyroidism. Figueiredo, B.C., Almazan, G., Ma, Y., Tetzlaff, W., Miller, F.D., Cuello, A.C. Brain Res. Mol. Brain Res. (1993) [Pubmed]
  5. Kidney ischemia-reperfusion regulates expression and distribution of tubulin subunits, beta-actin and rho GTPases in proximal tubules. Caron, A., Desrosiers, R.R., Béliveau, R. Arch. Biochem. Biophys. (2004) [Pubmed]
  6. Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. Basheer, R., Brown, R., Ramesh, V., Begum, S., McCarley, R.W. J. Neurosci. Res. (2005) [Pubmed]
  7. The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element. Lemischka, I., Sharp, P.A. Nature (1982) [Pubmed]
  8. Haploid expression of a mouse testis alpha-tubulin gene. Distel, R.J., Kleene, K.C., Hecht, N.B. Science (1984) [Pubmed]
  9. Distinct spatial localization of specific mRNAs in cultured sympathetic neurons. Bruckenstein, D.A., Lein, P.J., Higgins, D., Fremeau, R.T. Neuron (1990) [Pubmed]
  10. The nucleotide sequence of rat alpha-tubulin: 3'-end characteristics, and evolutionary conservation. Ginzburg, I., Behar, L., Givol, D., Littauer, U.Z. Nucleic Acids Res. (1981) [Pubmed]
  11. Sarin causes altered time course of mRNA expression of alpha tubulin in the central nervous system of rats. Damodaran, T.V., Mecklai, A.A., Abou-Donia, M.B. Neurochem. Res. (2002) [Pubmed]
  12. A rat monoclonal antibody reacting specifically with the tyrosylated form of alpha-tubulin. I. Biochemical characterization, effects on microtubule polymerization in vitro, and microtubule polymerization and organization in vivo. Wehland, J., Willingham, M.C., Sandoval, I.V. J. Cell Biol. (1983) [Pubmed]
  13. Distribution and gene expression of cytoskeletal proteins in two-cell rat embryos and developmental arrest. Matsumoto, H., Jiang, J.Y., Mitani, D., Sato, E. J. Exp. Zool. (2002) [Pubmed]
  14. Posttranslational modifications of alpha-tubulin: acetylated and detyrosinated forms in axons of rat cerebellum. Cambray-Deakin, M.A., Burgoyne, R.D. J. Cell Biol. (1987) [Pubmed]
  15. Changes in MAP2 and tyrosinated alpha-tubulin expression in cochlear inner hair cells after amikacin treatment in the rat. Ladrech, S., Lenoir, M. J. Comp. Neurol. (2002) [Pubmed]
  16. Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus. Pollard, H., Khrestchatisky, M., Moreau, J., Ben-Ari, Y., Represa, A. Neuroscience (1994) [Pubmed]
  17. Changes in neuronal protein 22 expression and cytoskeletal association in the alcohol-dependent and withdrawn rat brain. Depaz, I.M., de Las Heras, R., Kroon, P.A., Wilce, P.A. J. Neurosci. Res. (2005) [Pubmed]
  18. Direct photoaffinity labeling of tubulin with colchicine. Wolff, J., Knipling, L., Cahnmann, H.J., Palumbo, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  19. MTrasT24, a metallothionein-ras fusion gene, modulates expression in cultured rat liver cells of two genes associated with in vivo liver cancer. Li, Y.C., Seyama, T., Godwin, A.K., Winokur, T.S., Lebovitz, R.M., Lieberman, M.W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  20. Phosphorylation of alpha-tubulin carboxyl-terminal tyrosine prevents its incorporation into microtubules. Wandosell, F., Serrano, L., Avila, J. J. Biol. Chem. (1987) [Pubmed]
  21. Switching of beta- to alpha-tubulin phosphorylation in uterine smooth muscle of parturient rats. Joseph, M.K., Fernstrom, M.A., Soloff, M.S. J. Biol. Chem. (1982) [Pubmed]
  22. Identification of the binding region of basic calponin on alpha and beta tubulins. Fujii, T., Koizumi, Y. J. Biochem. (1999) [Pubmed]
  23. Acidic fibroblast growth factor enhances neurite outgrowth and stimulates expression of GAP-43 and T alpha 1 alpha-tubulin in cultured neurones from adult rat dorsal root ganglia. Mohiuddin, L., Fernyhough, P., Tomlinson, D.R. Neurosci. Lett. (1996) [Pubmed]
  24. Common and distinct tubulin binding sites for microtubule-associated proteins. Littauer, U.Z., Giveon, D., Thierauf, M., Ginzburg, I., Ponstingl, H. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  25. Beta-adrenergic and fibroblast growth factor receptors induce neuronal process outgrowth through different mechanisms. Kwon, J.H., Vogt Weisenhorn, D.M., Downen, M., Ruan, K., Roback, L., Joshi, H., Wainer, B.H. Eur. J. Neurosci. (1998) [Pubmed]
  26. Matrix metalloproteinase-9 promotes nerve growth factor-induced neurite elongation but not new sprout formation in vitro. Shubayev, V.I., Myers, R.R. J. Neurosci. Res. (2004) [Pubmed]
  27. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Hao, G., Derakhshan, B., Shi, L., Campagne, F., Gross, S.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  28. Differential expression of alpha-tubulin mRNA in rat cerebellum as revealed by in situ hybridization. Ginzburg, I., Teichman, A., Griffin, W.S., Littauer, U.Z. FEBS Lett. (1986) [Pubmed]
  29. Immunofluorescence distribution of alpha tubulin, beta tubulin and microtubule-associated protein 2 during in vitro maturation of cerebellar granule cell neurones. Cumming, R., Burgoyne, R.D., Lytton, N.A. Neuroscience (1984) [Pubmed]
  30. Glucocorticoid sensitivity of vasopressin mRNA levels in the paraventricular nucleus of the rat. Davis, L.G., Arentzen, R., Reid, J.M., Manning, R.W., Wolfson, B., Lawrence, K.L., Baldino, F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  31. Rapid induction of the major embryonic alpha-tubulin mRNA, T alpha 1, during nerve regeneration in adult rats. Miller, F.D., Tetzlaff, W., Bisby, M.A., Fawcett, J.W., Milner, R.J. J. Neurosci. (1989) [Pubmed]
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