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Gene Review

CHST1  -  carbohydrate (keratan sulfate Gal-6)...

Homo sapiens

Synonyms: C6ST, Carbohydrate sulfotransferase 1, GST-1, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1, KS6ST, ...
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Disease relevance of CHST1


High impact information on CHST1

  • Recently, three related sulfotransferases (keratan sulfate galactose-6-sulfotransferase [KSGal6ST], high endothelial cell N-acetylglucosamine-6-sulfotransferase [GlcNAc6ST], and human GlcNAc6ST) were cloned, which can generate Gal-6-sulfate and GlcNAc-6-sulfate in GlyCAM-1 [6].
  • The increased production of ethylene during carnation petal senescence regulates the transcription of the GST1 gene encoding a subunit of glutathione-S-transferase [7].
  • An ethylene-responsive enhancer element is involved in the senescence-related expression of the carnation glutathione-S-transferase (GST1) gene [7].
  • Deletion analysis of the 5' flanking sequences of GST1 identified a single positive regulatory element of 197 bp between -667 and -470 necessary for ethylene-responsive expression [7].
  • Disruption of the N-capping motif of helix 9 in hGST A1-1 alters the conformational dynamics of the C-terminal region and, consequently, the features of the H-site to which hydrophobic substrates (e.g. 1-chloro-2,4-dinitrobenzene (CDNB)) and nonsubstrates (e.g. 8-anilino-1-naphthalene sulfonate (ANS)) bind [8].

Chemical compound and disease context of CHST1


Biological context of CHST1


Anatomical context of CHST1


Associations of CHST1 with chemical compounds


Other interactions of CHST1


Analytical, diagnostic and therapeutic context of CHST1


  1. Liver glutathione S-transferase polymorphism in Japanese and its pharmacogenetic importance. Harada, S., Abei, M., Tanaka, N., Agarwal, D.P., Goedde, H.W. Hum. Genet. (1987) [Pubmed]
  2. Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. Okuda, T., Mita, S., Yamauchi, S., Matsubara, T., Yagi, F., Yamamori, D., Fukuta, M., Kuroiwa, A., Matsuda, Y., Habuchi, O. J. Biochem. (2000) [Pubmed]
  3. Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease. Nishimura, M., Kuno, S., Kaji, R., Yasuno, K., Kawakami, H. Mov. Disord. (2005) [Pubmed]
  4. Novel mutations in the CHST6 gene causing macular corneal dystrophy. Abbruzzese, C., Kuhn, U., Molina, F., Rama, P., De Luca, M. Clin. Genet. (2004) [Pubmed]
  5. Expression of SARS-coronavirus nucleocapsid protein in Escherichia coli and Lactococcus lactis for serodiagnosis and mucosal vaccination. Pei, H., Liu, J., Cheng, Y., Sun, C., Wang, C., Lu, Y., Ding, J., Zhou, J., Xiang, H. Appl. Microbiol. Biotechnol. (2005) [Pubmed]
  6. Sulfation of a high endothelial venule-expressed ligand for L-selectin. Effects on tethering and rolling of lymphocytes. Tangemann, K., Bistrup, A., Hemmerich, S., Rosen, S.D. J. Exp. Med. (1999) [Pubmed]
  7. An ethylene-responsive enhancer element is involved in the senescence-related expression of the carnation glutathione-S-transferase (GST1) gene. Itzhaki, H., Maxson, J.M., Woodson, W.R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases. Dirr, H.W., Little, T., Kuhnert, D.C., Sayed, Y. J. Biol. Chem. (2005) [Pubmed]
  9. The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Strange, R.C., Matharoo, B., Faulder, G.C., Jones, P., Cotton, W., Elder, J.B., Deakin, M. Carcinogenesis (1991) [Pubmed]
  10. CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. Li, X., Tu, L., Murphy, P.G., Kadono, T., Steeber, D.A., Tedder, T.F. J. Leukoc. Biol. (2001) [Pubmed]
  11. Catalog of 77 single-nucleotide polymorphisms (SNPs) in the carbohydrate sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes. Iida, A., Saito, S., Sekine, A., Mishima, C., Kitamura, Y., Kondo, K., Harigae, S., Osawa, S., Nakamura, Y. J. Hum. Genet. (2002) [Pubmed]
  12. CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. Li, X., Tedder, T.F. Genomics (1999) [Pubmed]
  13. Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase. Fukuta, M., Inazawa, J., Torii, T., Tsuzuki, K., Shimada, E., Habuchi, O. J. Biol. Chem. (1997) [Pubmed]
  14. Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase. Torii, T., Fukuta, M., Habuchi, O. Glycobiology (2000) [Pubmed]
  15. Enzymatic sulfation of galactose residue of keratan sulfate by chondroitin 6-sulfotransferase. Habuchi, O., Hirahara, Y., Uchimura, K., Fukuta, M. Glycobiology (1996) [Pubmed]
  16. Development of a simple homogeneous assay to screen for inhibitors of N-acetylglucosamine-6-sulfotransferases. Togame, H., Shimazaki, M., Yamato, A., Watanabe, S., Saito, K., Reinemer, P. Anal. Biochem. (2003) [Pubmed]
  17. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. Lee, J.K., Bistrup, A., van Zante, A., Rosen, S.D. Glycobiology (2003) [Pubmed]
  18. Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy. Ha, N.T., Chau, H.M., Cung, l.e. .X., Thanh, T.K., Fujiki, K., Murakami, A., Hiratsuka, Y., Kanai, A. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  19. Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. Mazany, K.D., Peng, T., Watson, C.E., Tabas, I., Williams, K.J. Biochim. Biophys. Acta (1998) [Pubmed]
  20. Glutathione S-transferases from larval Manduca sexta midgut: sequence of two cDNAs and enzyme induction. Snyder, M.J., Walding, J.K., Feyereisen, R. Insect Biochem. Mol. Biol. (1995) [Pubmed]
  21. Immunocytochemical evidence for the expression of GST1, GST2, and GST3 gene loci for glutathione S-transferase in human lung. Awasthi, Y.C., Singh, S.V., Ahmad, H., Moller, P.C. Lung (1987) [Pubmed]
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