Gene Review:
TIMELESS - timeless circadian clock
Homo sapiens
Synonyms:
Protein timeless homolog, TIM, TIM1, TIMELESS1, hTIM
- T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. Khademi, M., Illés, Z., Gielen, A.W., Marta, M., Takazawa, N., Baecher-Allan, C., Brundin, L., Hannerz, J., Martin, C., Harris, R.A., Hafler, D.A., Kuchroo, V.K., Olsson, T., Piehl, F., Wallström, E. J. Immunol. (2004)
- Specific structure appears at the N terminus in the sub-millisecond folding intermediate of the alpha subunit of tryptophan synthase, a TIM barrel protein. Wu, Y., Vadrevu, R., Yang, X., Matthews, C.R. J. Mol. Biol. (2005)
- Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction. Martynowski, D., Eyobo, Y., Li, T., Yang, K., Liu, A., Zhang, H. Biochemistry (2006)
- Expression of T cell immunoglobulin- and mucin-domain-containing molecules-1 and -3 (TIM-1 and -3) in the rat nervous and immune systems. Gielen, A.W., Lobell, A., Lidman, O., Khademi, M., Olsson, T., Piehl, F. J. Neuroimmunol. (2005)
- Vaccination with cell immunoglobulin mucin-1 antibodies and inactivated influenza enhances vaccine-specific lymphocyte proliferation, interferon-gamma production and cross-strain reactivity. Soo Hoo, W., Jensen, E.R., Saadat, A., Nieto, D., Moss, R.B., Carlo, D.J., Moll, T. Clin. Exp. Immunol. (2006)
- A time-less function for mouse timeless. Gotter, A.L., Manganaro, T., Weaver, D.R., Kolakowski LF, J.r., Possidente, B., Sriram, S., MacLaughlin, D.T., Reppert, S.M. Nat. Neurosci. (2000)
- Coupling of human circadian and cell cycles by the timeless protein. Unsal-Kaçmaz, K., Mullen, T.E., Kaufmann, W.K., Sancar, A. Mol. Cell. Biol. (2005)
- Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. Gotter, A.L., Suppa, C., Emanuel, B.S. J. Mol. Biol. (2007)
- The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement. Unsal-Kaçmaz, K., Chastain, P.D., Qu, P.P., Minoo, P., Cordeiro-Stone, M., Sancar, A., Kaufmann, W.K. Mol. Cell. Biol. (2007)
- The many facets of the Tim-Tipin protein families' roles in chromosome biology. McFarlane, R.J., Mian, S., Dalgaard, J.Z. Cell. Cycle. (2010)
- Drosophila timeless2 is required for chromosome stability and circadian photoreception. Benna, C., Bonaccorsi, S., Wülbeck, C., Helfrich-Förster, C., Gatti, M., Kyriacou, C.P., Costa, R., Sandrelli, F. Curr. Biol. (2010)
- TIM family of genes in immunity and tolerance. Kuchroo, V.K., Meyers, J.H., Umetsu, D.T., DeKruyff, R.H. Adv. Immunol. (2006)
- Temperature effect on entrainment, phase shifting, and amplitude of circadian clocks and its molecular bases. Rensing, L., Ruoff, P. Chronobiol. Int. (2002)
- The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. Young, M.W. Annu. Rev. Biochem. (1998)
- TIM Family of Genes in Immunity and Tolerance. Kuchroo, V.K., Meyers, J.H., Umetsu, D.T., Dekruyff, R.H. Adv. Immunol. (2006)
- Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Griffin, E.A., Staknis, D., Weitz, C.J. Science (1999)
- How mitochondria import hydrophilic and hydrophobic proteins. Chacinska, A., Pfanner, N., Meisinger, C. Trends Cell Biol. (2002)
- A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions. Blanquet, S., Zeijdner, E., Beyssac, E., Meunier, J.P., Denis, S., Havenaar, R., Alric, M. Pharm. Res. (2004)
- Economic evaluation of triflusal and aspirin in the treatment of acute myocardial infarction. Darbà, J., Izquierdo, I., Pontes, C., Navas, C., Rovira, J. PharmacoEconomics. (2002)
- Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Sangoram, A.M., Saez, L., Antoch, M.P., Gekakis, N., Staknis, D., Whiteley, A., Fruechte, E.M., Vitaterna, M.H., Shimomura, K., King, D.P., Young, M.W., Weitz, C.J., Takahashi, J.S. Neuron (1998)
- Mechanisms of protein import across the mitochondrial outer membrane. Lill, R., Neupert, W. Trends Cell Biol. (1996)
- Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase. Casals, N., Gómez-Puertas, P., Pié, J., Mir, C., Roca, R., Puisac, B., Aledo, R., Clotet, J., Menao, S., Serra, D., Asins, G., Till, J., Elias-Jones, A.C., Cresto, J.C., Chamoles, N.A., Abdenur, J.E., Mayatepek, E., Besley, G., Valencia, A., Hegardt, F.G. J. Biol. Chem. (2003)
- Human TIM-1 Associates with the TCR Complex and Up-Regulates T Cell Activation Signals. Binné, L.L., Scott, M.L., Rennert, P.D. J. Immunol. (2007)
- Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint. Yoshizawa-Sugata, N., Masai, H. J. Biol. Chem. (2007)
- The mitochondrial import machinery for preproteins. Rehling, P., Wiedemann, N., Pfanner, N., Truscott, K.N. Crit. Rev. Biochem. Mol. Biol. (2001)
- Prevention of the ischemia-induced decrease in mitochondrial Tom20 content by ischemic preconditioning. Boengler, K., Gres, P., Cabestrero, A., Ruiz-Meana, M., Garcia-Dorado, D., Heusch, G., Schulz, R. J. Mol. Cell. Cardiol. (2006)
- The exon 4 variations of Tim-1 gene are associated with rheumatoid arthritis in a Korean population. Chae, S.C., Song, J.H., Shim, S.C., Yoon, K.S., Chung, H.T. Biochem. Biophys. Res. Commun. (2004)
- TIM-1 regulates macrophage cytokine production and B7 family member expression. Hein, R.M., Woods, M.L. Immunol. Lett. (2007)
- The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis. Chae, S.C., Park, Y.R., Shim, S.C., Yoon, K.S., Chung, H.T. Immunol. Lett. (2004)
- Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. Forouhar, F., Hussain, M., Farid, R., Benach, J., Abashidze, M., Edstrom, W.C., Vorobiev, S.M., Xiao, R., Acton, T.B., Fu, Z., Kim, J.J., Miziorko, H.M., Montelione, G.T., Hunt, J.F. J. Biol. Chem. (2006)
- Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface. Téllez-Valencia, A., Olivares-Illana, V., Hernández-Santoyo, A., Pérez-Montfort, R., Costas, M., Rodríguez-Romero, A., López-Calahorra, F., Tuena De Gómez-Puyou, M., Gómez-Puyou, A. J. Mol. Biol. (2004)
- Differences in the intersubunit contacts in triosephosphate isomerase from two closely related pathogenic trypanosomes. Maldonado, E., Soriano-García, M., Moreno, A., Cabrera, N., Garza-Ramos, G., de Gómez-Puyou, M., Gómez-Puyou, A., Perez-Montfort, R. J. Mol. Biol. (1998)
- Epitope-Dependent Effect of Anti-Murine TIM-1 Monoclonal Antibodies on T Cell Activity and Lung Immune Responses. Sizing, I.D., Bailly, V., McCoon, P., Chang, W., Rao, S., Pablo, L., Rennard, R., Walsh, M., Li, Z., Zafari, M., Dobles, M., Tarilonte, L., Miklasz, S., Majeau, G., Godbout, K., Scott, M.L., Rennert, P.D. J. Immunol. (2007)
- Exploring the environmental preference of weak interactions in (alpha/beta)8 barrel proteins. Chakkaravarthi, S., Babu, M.M., Gromiha, M.M., Jayaraman, G., Sethumadhavan, R. Proteins (2006)
- Triose phosphate isomerase, a novel enzyme-crystallin, and tau-crystallin in crocodile cornea. High accumulation of both proteins during late embryonic development. Kathiresan, T., Krishnan, K., Krishnakumar, V., Agrawal, R., Anand, A., Muralidhar, D., Mishra, A.K., Dhople, V.M., Aggrawal, R.K., Sharma, Y. FEBS J. (2006)
- JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Koh, K., Zheng, X., Sehgal, A. Science (2006)