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Gene Review

NLRP12  -  NLR family, pyrin domain containing 12

Homo sapiens

Synonyms: CLR19.3, FCAS2, Monarch-1, Monarch1, NACHT, LRR and PYD domains-containing protein 12, ...
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Disease relevance of NLRP12


Psychiatry related information on NLRP12


High impact information on NLRP12

  • In this report, we show that Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes [5].
  • Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-{kappa}B Activation and p52-Dependent Chemokine Expression in Monocytes [5].
  • Because Monarch-1 is the first CLR protein that interferes with both TLR2 and TLR4 activation, the mechanism of this interference is significant [1].
  • We find that Monarch-1 associates with IRAK-1 but not MyD88, resulting in the blockage of IRAK-1 hyperphosphorylation [1].
  • Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes [6].

Biological context of NLRP12


Anatomical context of NLRP12

  • Among these, Monarch-1 operates as a novel attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes [5].
  • Ghost membranes made from sensitizer-treated cells were effective generators of singlet oxygen, assayed by RNO bleaching [11].
  • The IOL is placed in a Monarch II B cartridge (Alcon) designed for use with the 5.5 mm optic AcrySof SA30AL, and the tip of the cartridge is inserted in the incision but not the anterior chamber [12].
  • The testicularly expressed histone genes H1t, Th2a and Th2b could be assigned to rat chromosome (RNO) 17 by PCR analysis of somatic cell hybrid DNAs [13].

Associations of NLRP12 with chemical compounds


Other interactions of NLRP12


Analytical, diagnostic and therapeutic context of NLRP12

  • We describe a simple and rapid particle-enhanced turbidimetric immunoassay suitable for routine application in a Monarch 2000 centrifugal analyzer with commercially available reagents [21].
  • We report a method to insert a 3-piece AcrySof MA30BA acrylic foldable intraocular lens (IOL) (Alcon) in a single action using a Monarch II (Alcon) injector [22].
  • Electron donating free radicals NAD(.), (.)CO2(-), MV(.)+, and e(aq)-, generated by pulse radiolysis, reduce resazurin (RNO) with rate constants of 1.9 x 10(9), 2.8 x 10(9), 4.8 x 10(9), and 2.3 x 10(10) M(-1) s(-1), respectively, neutral solution [23].
  • RESULTS: Overall, the IOLs were easy to implant with no haptic or optic damage using a forceps or the Monarch injector [24].
  • Photodynamic quantum yields of singlet oxygen production (RNO bleaching assay) and rate of superoxide generation (SOD inhibitable ferricytochrome c reduction assay and EPR spin trapping experiments using 5,5-dimethyl-1-pyrroline-N-oxide as spin trap) by the metal complexes have been studied [25].


  1. The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. Williams, K.L., Lich, J.D., Duncan, J.A., Reed, W., Rallabhandi, P., Moore, C., Kurtz, S., Coffield, V.M., Accavitti-Loper, M.A., Su, L., Vogel, S.N., Braunstein, M., Ting, J.P. J. Biol. Chem. (2005) [Pubmed]
  2. Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Collins, S.C., Wallis, R.H., Wilder, S.P., Wallace, K.J., Argoud, K., Kaisaki, P.J., Bihoreau, M.T., Gauguier, D. Mamm. Genome (2006) [Pubmed]
  3. Postmortem lipid levels for the analysis of risk factors of sudden death: usefulness of the Ektachem and Monarch analyzers. Hart, A.P., Zumwalt, R.E., Dasgupta, A. The American journal of forensic medicine and pathology : official publication of the National Association of Medical Examiners. (1997) [Pubmed]
  4. Leuprolide acetate suppresses pedophilic urges and arousability. Schober, J.M., Kuhn, P.J., Kovacs, P.G., Earle, J.H., Byrne, P.M., Fries, R.A. Archives of sexual behavior. (2005) [Pubmed]
  5. Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-{kappa}B Activation and p52-Dependent Chemokine Expression in Monocytes. Lich, J.D., Williams, K.L., Moore, C.B., Arthur, J.C., Davis, B.K., Taxman, D.J., Ting, J.P. J. Immunol. (2007) [Pubmed]
  6. Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes. Williams, K.L., Taxman, D.J., Linhoff, M.W., Reed, W., Ting, J.P. J. Immunol. (2003) [Pubmed]
  7. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. Wang, L., Manji, G.A., Grenier, J.M., Al-Garawi, A., Merriam, S., Lora, J.M., Geddes, B.J., Briskin, M., DiStefano, P.S., Bertin, J. J. Biol. Chem. (2002) [Pubmed]
  8. Genomewide assessment of genetic alterations in DMBA-induced rat sarcomas: cytogenetic, CGH, and allelotype analyses reveal recurrent DNA copy number changes in rat chromosomes 1, 2, 4, and 7. Walentinsson, A., Sjöling, A., Helou, K., Klinga-Levan, K., Levan, G. Genes Chromosomes Cancer (2000) [Pubmed]
  9. Molecular basis for the insensitivity of the Monarch (Danaus plexippus) to cardiac glycosides. Holzinger, F., Frick, C., Wink, M. FEBS Lett. (1992) [Pubmed]
  10. Comparative mapping of mouse and rat chromosomes by fluorescence in situ hybridization. Grützner, F., Himmelbauer, H., Paulsen, M., Ropers, H.H., Haaf, T. Genomics (1999) [Pubmed]
  11. Photooxidation of cell membranes using eosin derivatives that locate in lipid or protein to study the role of diffusible intermediates. Pooler, J.P. Photochem. Photobiol. (1989) [Pubmed]
  12. 6.5 mm optic AcrySof implantation through a 3.0 mm incision. Tsuneoka, H., Hayama, A., Takahama, M., Takashina, H. Journal of cataract and refractive surgery. (2003) [Pubmed]
  13. Chromosome mapping of rat histone genes H1fv, H1d, H1t, Th2a and Th2b. Walter, L., Klinga-Levan, K., Helou, K., Albig, W., Drabent, B., Doenecke, D., Günther, E., Levan, G. Cytogenet. Cell Genet. (1996) [Pubmed]
  14. Glucose test "carryover" affects drug assays on the IL Monarch. Overfield, C.V., Ellis, K.J., Lorton, L.S. Clin. Chem. (1987) [Pubmed]
  15. Reliability of IL Monarch ion-selective electrode module for sodium, potassium, and chloride measurements. Guagnellini, E., Spagliardi, G., Bernardi, G., Stella, P. Clin. Chem. (1988) [Pubmed]
  16. Measurement of plasma phenytoin by EMIT in the Monarch centrifugal analyzer: studies on the elimination of within-rotor drift. Wenham, P.R., Barbour, H.M. Clin. Chem. (1988) [Pubmed]
  17. Enzymatic assay of salicylate adapted to the Monarch centrifugal analyzer. Chubb, S.A., Hutchison, A. Clin. Chem. (1989) [Pubmed]
  18. Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. Arthur, J.C., Lich, J.D., Aziz, R.K., Kotb, M., Ting, J.P. J. Immunol. (2007) [Pubmed]
  19. Genomic mining of new genes and pathways in innate and adaptive immunity. Ting, J. Novartis Found. Symp. (2005) [Pubmed]
  20. Decreased total antioxidant capacity but normal lipid hydroperoxide concentrations in sera of critically ill patients. Dasgupta, A., Malhotra, D., Levy, H., Marcadis, D., Blackwell, W., Johnston, D. Life Sci. (1997) [Pubmed]
  21. Automated latex agglutination immunoassay of serum ferritin with a centrifugal analyzer. Simó, J.M., Joven, J., Clivillé, X., Sans, T. Clin. Chem. (1994) [Pubmed]
  22. Single-action implantation of a 3-piece acrylic intraocular lens with an injector. Takeshita, T., Yamada, K., Tanihara, H. Journal of cataract and refractive surgery. (2003) [Pubmed]
  23. Photocatalytic and free radical interactions of the heterocyclic N-oxide resazurin with NADH, GSH, and Dopa. Prütz, W.A., Butler, J., Land, E.J. Arch. Biochem. Biophys. (1996) [Pubmed]
  24. Clinical performance of Alcon SA30AL and SA60AT single-piece acrylic intraocular lenses. Davison, J.A. Journal of cataract and refractive surgery. (2002) [Pubmed]
  25. Synthesis, X-ray crystal structure, antimicrobial activity and photodynamic effects of some thiabendazole complexes. Mothilal, K.K., Karunakaran, C., Rajendran, A., Murugesan, R. J. Inorg. Biochem. (2004) [Pubmed]
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