Disease relevance of NLRP12

• The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals [1].
• Genetic studies in experimental crosses derived from the inbred Goto-Kakizaki (GK) rat model of spontaneous diabetes mellitus have identified quantitative trait loci (QTL) for diabetes phenotypes in a large region of rat Chromosome (RNO) 1 [2].
• Postmortem lipid levels for the analysis of risk factors of sudden death: usefulness of the Ektachem and Monarch analyzers [3].

Psychiatry related information on NLRP12

• Testosterone levels, sexual interest preference by visual reaction time (Abel Assessment), penile tumescence (Monarch Penile Plethysmography, PPG), as well as strong sexual urges toward children and masturbatory frequency involving thoughts of children (polygraph), were measured every 3 months [4].

High impact information on NLRP12

• In this report, we show that Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes [5].
• Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-{kappa}B Activation and p52-Dependent Chemokine Expression in Monocytes [5].
• Because Monarch-1 is the first CLR protein that interferes with both TLR2 and TLR4 activation, the mechanism of this interference is significant [1].
• We find that Monarch-1 associates with IRAK-1 but not MyD88, resulting in the blockage of IRAK-1 hyperphosphorylation [1].
• Cutting edge: Monarch-1: a pyrin/nucleotide-binding domain/leucine-rich repeat protein that controls classical and nonclassical MHC class I genes [6].

Biological context of NLRP12

• The expression of PYPAF7 is highly restricted to immune cells, and its gene maps to chromosome 19q13.4, a locus that contains a cluster of genes encoding numerous PYPAF family members [7].
• The combined results suggested that genetic alterations detected in RNO2 and RNO12 usually corresponded to complete or partial trisomy, whereas those in RNO1 and RNO7 seemed to involve regional deletions and/or gains [8].
• The most conspicuous finding in the cytogenetic analysis was a high incidence of trisomy for rat chromosome 2 (RNO2) [8].
• Instead of the amino acid asparagine at position 122 in ouabain-sensitive insects, the Monarch has a histidine in the putative ouabain binding site, which consists of about 12 amino acids [9].
• Comparative fluorescence in situ hybridization mapping using DNA libraries from flow-sorted mouse chromosomes and region-specific mouse BAC clones on rat chromosomes reveals chromosomal homologies between mouse (Mus musculus, MMU) and rat (Rattus norvegicus, RNO) [10].

Anatomical context of NLRP12

• Among these, Monarch-1 operates as a novel attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes [5].
• Ghost membranes made from sensitizer-treated cells were effective generators of singlet oxygen, assayed by RNO bleaching [11].
• The IOL is placed in a Monarch II B cartridge (Alcon) designed for use with the 5.5 mm optic AcrySof SA30AL, and the tip of the cartridge is inserted in the incision but not the anterior chamber [12].
• The testicularly expressed histone genes H1t, Th2a and Th2b could be assigned to rat chromosome (RNO) 17 by PCR analysis of somatic cell hybrid DNAs [13].

Associations of NLRP12 with chemical compounds

• Monarch-1 has four different splice forms due to the differential splicing of leucine-rich repeat motifs [6].
• Glucose test "carryover" affects drug assays on the IL Monarch [14].
• Reliability of IL Monarch ion-selective electrode module for sodium, potassium, and chloride measurements [15].
• Measurement of plasma phenytoin by EMIT in the Monarch centrifugal analyzer: studies on the elimination of within-rotor drift [16].
• Enzymatic assay of salicylate adapted to the Monarch centrifugal analyzer [17].
• Using a two-dimensional gel/mass spectrometry system, we detected the association of the nucleotide-binding domain leucine-rich repeat protein Monarch-1 with heat shock proteins [18].

Other interactions of NLRP12

• Detailed analysis and new functional data regarding a number of the CATERPILLAR proteins will be described, including CIITA, cryopyrin and Monarch 1 [19].
• We automated assays estimating the antioxidant status of serum, and lipid hydroperoxide concentrations using the Monarch analyzer [20].

Analytical, diagnostic and therapeutic context of NLRP12

• We describe a simple and rapid particle-enhanced turbidimetric immunoassay suitable for routine application in a Monarch 2000 centrifugal analyzer with commercially available reagents [21].
• We report a method to insert a 3-piece AcrySof MA30BA acrylic foldable intraocular lens (IOL) (Alcon) in a single action using a Monarch II (Alcon) injector [22].
• Electron donating free radicals NAD(.), (.)CO2(-), MV(.)+, and e(aq)-, generated by pulse radiolysis, reduce resazurin (RNO) with rate constants of 1.9 x 10(9), 2.8 x 10(9), 4.8 x 10(9), and 2.3 x 10(10) M(-1) s(-1), respectively, neutral solution [23].
• RESULTS: Overall, the IOLs were easy to implant with no haptic or optic damage using a forceps or the Monarch injector [24].
• Photodynamic quantum yields of singlet oxygen production (RNO bleaching assay) and rate of superoxide generation (SOD inhibitable ferricytochrome c reduction assay and EPR spin trapping experiments using 5,5-dimethyl-1-pyrroline-N-oxide as spin trap) by the metal complexes have been studied [25].

References