The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NUMBL  -  numb homolog (Drosophila)-like

Homo sapiens

Synonyms: CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NUMBL


Psychiatry related information on NUMBL

  • Even if hypertension only results in a moderately increased risk of AD, or overall dementia, better treatment of hypertension may have an immense effect on the total numbr of demented individuals [5].

High impact information on NUMBL

  • This resulted in severe damage to brain lateral ventricle integrity and identified roles for Numb/Numblike in regulating ependymal wall integrity and SVZ neuroblast survival [6].
  • The Notch-mediated reduction of Numblike required the PEST domain in the Numblike protein and was blocked by the proteasome inhibitor MG132 [7].
  • Absorption studies showed a partial homology between the NBL 108cc15 and human sciatic nerve [2].
  • In contrast, the 10-micrograms ampicillin disk failed to detect 44% (8 of 18) of the ampicillin-resistant NBLP strains (a zone diameter of less than or equal to 19 mm was considered resistant) [3].
  • Numb and its homologue, Numb-like (Numbl), play important roles in mammalian development, but their role in embryonic development of lower vertebrates remains unknown [8].

Biological context of NUMBL

  • We searched for the TCF/LEF-binding site within the promoter region of NUMB and NUMBL genes [9].
  • Loss of chromosome 1p may have a prognostic value in localised neuroblastoma: results of the French NBL 90 Study. Neuroblastoma Study Group of the Société Française d'Oncologie Pédiatrique (SFOP) [10].
  • An assessment of the BPD/NBL ratio may improve the diagnosis of trisomy 21 when used with current prenatal screening practices [11].
  • CONCLUSIONS: The second-trimester BPD/NBL ratio was a significant and independent predictor of trisomy 21 [11].
  • We questioned whether strains of ampicillin-resistant, non-beta-lactamase-producing (AmpR NBLP) Haemophilus influenzae with lower affinity penicillin-binding proteins (PBPs) might have altered virulence [12].

Anatomical context of NUMBL

  • EXPERIMENTAL DESIGN: Northern blotting and in situ hybridization were used to study ras protooncogene mRNA expression in the DLPs of NBL rats harboring sex steroid-induced ductal dysplasia and to compare findings with those from prostates of castrated and castrated androgen-treated animals [13].
  • The biparietal diameter: nasal bone length ratio (BPD/NBL) was also calculated [14].
  • RESULTS: The mean NBL was shorter (mean +/- SD, 2.3+/-1.7 mm versus 3.9+/-1.2 mm; P<.001) and the BPD/NBL ratio was greater (17.7 [range, 6.2-114] versus 11.7 [range, 5.8-80]; P<.001) in the fetuses with trisomy 21 [11].
  • Bone marrow involvement was more common in NBL patients [15].
  • Each inter-dental site that was readable was scored as one for the following categories: not available (NA); no bone loss (NBL)- the CEJ-ABC was < or =2 mm; questionable bone loss (QBL): the distance from the CEJ-ABC was >2 and <3 mm; and definite bone loss (DBL): the distance from the CEJ to ABC was > or =3 mm [16].

Associations of NUMBL with chemical compounds

  • In this study we investigated the chronic toxic and carcinogenic effects of cadmium in the Noble (NBL/Cr) rat, with particular attention to lesions of the prostate [17].
  • METHODS: A recent case of NBL 4S seen at the Sophia Children's Hospital led the authors to review their patient charts from 1971 onward, as well as the literature, for the treatment modalities used and the outcome in treated versus nontreated patients [18].

Analytical, diagnostic and therapeutic context of NUMBL

  • Forty-two percent of the patients showed a positive immunofluorescence test against the NBL 108cc15 [2].
  • We conclude that surgery alone is sufficient for patients with stage I NBL, that RT and chemotherapy do not appear to alter the outcome in stage II patients, and better methods of therapy are needed for patients with stage III disease [19].
  • AIM: To investigate the usefulness of assaying endotoxin in non-directed bronchial lavage fluid (NBL), bronchoscopic bronchoalveolar lavage fluid (BAL), and sera as a means of diagnosing Gram negative, ventilator associated pneumonia [20].
  • In this study, our goal was to characterize the physiology of tumor immunosurveillance in children with high-risk neuroblastoma (HR-NBL) [21].
  • The NBL patients who underwent surgery by two surgeons had a longer length of stay (P = 0.008) [22].


  1. N-Myc gene amplification is a major prognostic factor in localized neuroblastoma: results of the French NBL 90 study. Neuroblastoma Study Group of the Société Francaise d'Oncologie Pédiatrique. Rubie, H., Hartmann, O., Michon, J., Frappaz, D., Coze, C., Chastagner, P., Baranzelli, M.C., Plantaz, D., Avet-Loiseau, H., Bénard, J., Delattre, O., Favrot, M., Peyroulet, M.C., Thyss, A., Perel, Y., Bergeron, C., Courbon-Collet, B., Vannier, J.P., Lemerle, J., Sommelet, D. J. Clin. Oncol. (1997) [Pubmed]
  2. Anti-neuroblastoma cell line antibodies in inflammatory demyelinating polyneuropathy: inhibition in vitro and in vivo by IV immunoglobulin. van Doorn, P.A., Brand, A., Vermeulen, M. Neurology (1988) [Pubmed]
  3. Failure to detect ampicillin-resistant, non-beta-lactamase-producing Haemophilus influenzae by standard disk susceptibility testing. Mendelman, P.M., Chaffin, D.O., Clausen, C., Stull, T.L., Needham, C., Williams, J.D., Smith, A.L. Antimicrob. Agents Chemother. (1986) [Pubmed]
  4. Use of animal models in defining efficacy of chemoprevention agents against prostate cancer. Bosland, M.C. Eur. Urol. (1999) [Pubmed]
  5. Hypertension, hypertension-clustering factors and Alzheimer's disease. Skoog, I., Gustafson, D. Neurol. Res. (2003) [Pubmed]
  6. Postnatal deletion of numb/numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., Jan, Y.N. Cell (2006) [Pubmed]
  7. High levels of Notch signaling down-regulate Numb and Numblike. Chapman, G., Liu, L., Sahlgren, C., Dahlqvist, C., Lendahl, U. J. Cell Biol. (2006) [Pubmed]
  8. Zebrafish Numb homologue: phylogenetic evolution and involvement in regulation of left-right asymmetry. Niikura, Y., Tabata, Y., Tajima, A., Inoue, I., Arai, K., Watanabe, S. Mech. Dev. (2006) [Pubmed]
  9. NUMB is a break of WNT-Notch signaling cycle. Katoh, M., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  10. Loss of chromosome 1p may have a prognostic value in localised neuroblastoma: results of the French NBL 90 Study. Neuroblastoma Study Group of the Société Française d'Oncologie Pédiatrique (SFOP). Rubie, H., Delattre, O., Hartmann, O., Combaret, V., Michon, J., Bénard, J., Peyroulet, M.C., Plantaz, D., Coze, C., Chastagner, P., Baranzelli, M.C., Frappaz, D., Lemerle, J., Sommelet, D. Eur. J. Cancer (1997) [Pubmed]
  11. Second-trimester biparietal diameter/nasal bone length ratio is an independent predictor of trisomy 21. Tran, L.T., Carr, D.B., Mitsumori, L.M., Uhrich, S.B., Shields, L.E. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. (2005) [Pubmed]
  12. Virulence of non-beta-lactamase-mediated ampicillin-resistant Haemophilus influenzae. Rubin, L.G., Mendelman, P.M., Rakita, R.M., Rosen, H. FEMS Microbiol. Lett. (1991) [Pubmed]
  13. Early alterations in ras protooncogene mRNA expression in testosterone and estradiol-17 beta induced prostatic dysplasia of noble rats. Yu, M., Leav, B.A., Leav, I., Merk, F.B., Wolfe, H.J., Ho, S.M. Lab. Invest. (1993) [Pubmed]
  14. Fetal nasal bone and trisomy 21 in the second trimester. Viora, E., Errante, G., Sciarrone, A., Bastonero, S., Masturzo, B., Martiny, G., Campogrande, M. Prenat. Diagn. (2005) [Pubmed]
  15. Small noncleaved follicular center cell lymphoma: Burkitt's and non-Burkitt's variants in the US. II. Pathologic and immunologic features. Pavlova, Z., Parker, J.W., Taylor, C.R., Levine, A.M., Feinstein, D.I., Lukes, R.J. Cancer (1987) [Pubmed]
  16. Radiographic study of the prevalence of periodontal bone loss in Australian school-aged children attending the Royal Dental Hospital of Melbourne. Darby, I.B., Lu, J., Calache, H. Journal of clinical periodontology. (2005) [Pubmed]
  17. Carcinogenic effects of cadmium in the noble (NBL/Cr) rat: induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral prostate. Waalkes, M.P., Anver, M., Diwan, B.A. Toxicol. Sci. (1999) [Pubmed]
  18. Neuroblastoma 4S: a heterogeneous disease with variable risk factors and treatment strategies. van Noesel, M.M., Hählen, K., Hakvoort-Cammel, F.G., Egeler, R.M. Cancer (1997) [Pubmed]
  19. The role of multimodal therapy in patients with local and regional neuroblastoma. Evans, A.E., D'Angio, G.J., Koop, C.E. J. Pediatr. Surg. (1984) [Pubmed]
  20. Diagnosis of gram negative, ventilator associated pneumonia by assaying endotoxin in bronchial lavage fluid. Flanagan, P.G., Jackson, S.K., Findlay, G. J. Clin. Pathol. (2001) [Pubmed]
  21. Immunosurveillance and survivin-specific T-cell immunity in children with high-risk neuroblastoma. Coughlin, C.M., Fleming, M.D., Carroll, R.G., Pawel, B.R., Hogarty, M.D., Shan, X., Vance, B.A., Cohen, J.N., Jairaj, S., Lord, E.M., Wexler, M.H., Danet-Desnoyers, G.A., Pinkus, J.L., Pinkus, G.S., Maris, J.M., Grupp, S.A., Vonderheide, R.H. J. Clin. Oncol. (2006) [Pubmed]
  22. Two-surgeon versus single-surgeon radical cystectomy and urinary diversion: impact on patient outcomes and costs. Ludwig, A.T., Inampudi, L., O'Donnell, M.A., Kreder, K.J., Williams, R.D., Konety, B.R. Urology (2005) [Pubmed]
WikiGenes - Universities