Disease relevance of Laminaria

• A Laminaria saccharina genomic library in the phage EMBL 4 was used to isolate and sequence a full-length gene encoding a fucoxanthin-chlorophyll a/c-binding protein [1].
• The sensitivity of the assay was approximately 50 pg/ml both for curdlan from Alcaligenes faecalis and for laminarin from Laminaria digitata [2].
• Uterine rupture following midtrimester abortion by laminaria, prostaglandin F2alpha, and oxytocin: report of two cases [3].
• Clostridial sepsis after abortion with PGF2alpha and intracervical laminaria tents--a case report [4].
• In animals given indomethacin following insertion of laminaria, both granulation-tissue formation and bone resorption were inhibited [5].

High impact information on Laminaria

• To generate a vaccine to protect against a variety of human pathogenic fungi, we conjugated laminarin (Lam), a well-characterized but poorly immunogenic beta-glucan preparation from the brown alga Laminaria digitata, with the diphtheria toxoid CRM197, a carrier protein used in some glyco-conjugate bacterial vaccines [6].
• Components of Laminaria which might account for the observed difference in mammary tumor growth are varied and include the sulfated polysaccharide fucoidan . Rats in the top row of cages had a significant (p = 0.01) delay in time to tumor compared to rats in the lower four rows [7].
• Different haloperoxidases, one specific for the oxidation of iodide and another that can oxidize both iodide and bromide, were separated from the sporophytes of the brown alga Laminaria digitata and purified to electrophoretic homogeneity [8].
• Laminarin, a linear beta-1,3 glucan (mean degree of polymerization of 33) was extracted and purified from the brown alga Laminaria digitata [9].
• Resonance Raman spectroscopy of a light-harvesting protein from the brown alga Laminaria saccharina [10].

Biological context of Laminaria

• Misoprostol compared with laminaria before early second-trimester surgical abortion: a randomized trial [11].
• Significant positive, linear slopes of regression were found for achieved dilation versus weeks of gestation for thick laminaria tents and magnesium sulfate devices but not for Hypan tents [12].
• Although the hydrophilic property of laminaria is considered to be the principal mechanism promoting cervical dilatation, laminaria may alter the elaboration, release, or degradation of uterine prostaglandin F2 alpha [13].
• OBJECTIVE: Extra-amniotic saline infusion has been shown to be equal to or more efficacious than misoprostol, laminaria, dinoprostone, and prostaglandin estradiol for cervical ripening and labor induction [14].
• Cervical dilation before first-trimester elective abortion: a controlled comparison of meteneprost, laminaria, and hypan [15].

Anatomical context of Laminaria

• METHODS: We conducted a randomized, double-blind, placebo-controlled trial comparing oral misoprostol 400 microg, vaginal misoprostol 400 microg, and one medium laminaria for dilating the cervix over 4 hours before surgical abortion [16].
• Plasma levels of unconjugated oestrone, oestradiol, oestriol and progesterone were serially studied in six uncomplicated patients in the mid-trimester of pregnancy before and during abortion induced by purely mechanical stretching of the uterus by laminaria and rubber balloon [17].
• Values for PAI-1 in the decidua were higher in the laminaria tent group than in controls, and those for PAI-2 in the placenta were lower [18].

Associations of Laminaria with chemical compounds

• The N-terminus of the major polypeptide component of the light-harvesting complex (LHC) from the brown alga Laminaria saccharina is blocked [19].
• Vanadium-dependent iodoperoxidases in Laminaria digitata, a novel biochemical function diverging from brown algal bromoperoxidases [20].
• An aerobic, polarly flagellated marine bacterium that produces a prodigiosin-like pigment was isolated from the red-spotted culture beds of Laminaria japonica [21].
• Experiments with the marine alga Laminaria digitata demonstrated that natural haloperoxidase systems are capable of mediating the deactivation of acylated homoserine lactones [22].
• Procedures performed after laminaria were significantly faster than those after misoprostol (median 3.4 versus 7.2 minutes, respectively, P = .01) [11].

Gene context of Laminaria

• Placental and decidual u-PA, t-PA, PAI-1 and PAI-2 concentrations, as affected by cervical dilatation with laminaria tents or Hegar dilators [18].
• CONCLUSIONS: Insertion of laminaria leads to increase concentration of IL-1 beta, IL-8, PGE2, PGF2 alpha and elastase activity [23].
• RESULTS: IL-1 beta and IL-8 and elastase activity were significantly increased after insertion of laminaria (p<0.0001 and 0.001 respectively) [23].
• An inactivation of u-PA by PAI-1 might explain the lack of increase in BL among the laminaria tent group [24].
• There appears to be a potential role for Laminaria, estrogens, relaxin, and various forms and routes of administration of prostaglandins because efficacy has been reported with all of these methods [25].

Analytical, diagnostic and therapeutic context of Laminaria

• RESULTS: The median induction-abortion interval in the mifepristone group (7.5 h) was significantly shorter than that in the laminaria tent group (11 h) and significantly fewer gemeprost pessaries were required [26].
• The complete abortion rate was also similar between women receiving misoprostol alone (39.3%) and the group receiving misoprostol and laminaria (37.5%) [27].
• To evaluate the time course of lidocaine plasma levels following paracervical infiltration, plasma lidocaine determinations were obtained in 25 patients undergoing suction curettage without laminaria pretreatment and in 24 patients undergoing suction curettage after laminaria pretreatment [28].
• Termination of second-trimester pregnancy by laminaria and intramuscular injections of 15-methyl PGF2 alpha or 16-phenoxy-omega-17,18,19, 20-tetranor PGE2 methyl sulfonylamide. A randomized study [29].
• If buccal misoprostol eliminates or reduces the need for phased, multiday laminaria 1-3 days prior to the surgical procedure, then its use may offer service advantages such as reduced number of clinic visits and fewer pelvic examinations per woman [30].

References