Disease relevance of Iritis

• There was no statistically significant difference between acyclovir and vidarabine for the treatment of epithelial keratitis in reference to epithelial healing, post-treatment visual acuity, or iritis [1].
• Anterior uveitis/iritis has been reported frequently with intravenous cidofovir in postmarketing reports and a small number of patients have developed hypotony [2].
• In 1985, Blau reported a family with 11 members in four generations affected by granulomatous arthritis, iritis, skin rash, and periarticular synovial cysts [3].
• The biopsies from patients with iritis, RA, and Crohn's disease showed a granulomatous vasculitis and a granuloma annulare-like tissue reaction [4].
• 2'-O-glycylacyclovir, a water-soluble ester derivative of acyclovir, has proved efficacious in the topical treatment of epithelial and stromal herpes simplex keratitis, and iritis therewith associated, when administered as a 1% eyedrop formulation to rabbits [5].

High impact information on Iritis

• Mild iritis developed after 14% of the injections that had been preceded by prophylaxis with oral probenecid [6].
• Effect of etanercept on iritis in patients with ankylosing spondylitis [7].
• The iritis resolved after combined treatment with intravenous cyclophosphamide (1,500 mg/month), high-dose prednisone (60 mg/day), and cyclosporine (5 mg/kg/day) [8].
• Secondary outcomes included incidence of iritis and changes in intraocular pressure (IOP) after cidofovir injections [9].
• RESULTS: Mild to moderate nongranulomatous iritis was seen in 26% of patients after their first injection (n = 12) [10].

Chemical compound and disease context of Iritis

• Also, it may be that these compounds have a combined effect with other antiviral agents, such as vidarabine, increasing their potency against stromal disease and iritis [11].
• Given a normal postoperative topical steroid regimen, there were no cases of substantially increased or prolonged iritis [12].
• Inhibition of prostaglandin-induced iritis. Topical indoxole vs indomethacin therapy [13].
• Cocaine-induced iritis [14].
• Iritis from implantation trauma was avoided by intravenous administration of 250 mg prednisone preoperatively [15].

Biological context of Iritis

• No statistical difference in SLPI levels was found between controls (cataract) and other pathologies, while patients with iritis/uveitis had higher SLPI levels compared to those with diabetes (P<0.05) [16].
• The iris vessels showed fluorescein leakage as a sign of irritative iritis during the active stage of simple and chronic corneal ulcers, in disciform keratitis, Mooren's ulcer, and in graft rejection [17].

Anatomical context of Iritis

• Ocular vascular lesions consisted of iridal congestion with iridal hemorrhage and associated acute iritis and aqueous flare in some rabbits [18].

Gene context of Iritis

• The only significant difference between those patients with an iritis and those with only pelvospondylitis was an elevated CRP in the iritis group (p less than 0.01) [19].
• RESULTS: Four of the parents had had JIA (one subsequently developed ankylosing spondylitis), and 4 had rheumatoid factor-negative chronic arthritis (one had also had chronic iritis since the age of 10, resembling that seen in JIA) [20].
• Based on this information the type of uveitis will be named (eg, acute, nongranulomatous, unilateral, anterior uveitis) and matched (meshing) to a potential list of etiologies (eg, viral iritis, HLA-B 27 associated iritis) [21].
• Analysis of individuals with B27 AS with iritis revealed significant differences in allelic distribution of this biallelic locus compared to patients with B27 AS without iritis [22].
• When present, antibodies to a 45 kDa protein occur only in sera from children without iritis and not in those with active iritis [23].

Analytical, diagnostic and therapeutic context of Iritis

• From 43 Nepalese leprosy patients skin smear negative, and treated with dapsone (diamino diphenyl sulphone), and without any sign of active leprosy or iritis, specimens from iridectomy during cataract surgery were studied histopathologically [24].
• This raises the question whether these can survive systemically despite dapsone chemotherapy in the iris, thus leading to dapsone-resistant leprosy and to recurrent iritis [24].
• Following minor surgery performed under topical application of oxybuprocaine (Dorsacaine, Novesin) two patients suffered from fibrinous iritis and moderate corneal swelling [25].
• Intravenously, Ara A has been shown in our double-blind studies to be effective against herpetic iritis and deep stromal disease, whereas no topical agent has been shown to be of use in man in treating these problems [26].
• Acute granulomatous iritis following 5 fluorouracil therapy for failed trabeculectomy [27].

References