The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Iritis


High impact information on Iritis


Chemical compound and disease context of Iritis


Biological context of Iritis

  • No statistical difference in SLPI levels was found between controls (cataract) and other pathologies, while patients with iritis/uveitis had higher SLPI levels compared to those with diabetes (P<0.05) [16].
  • The iris vessels showed fluorescein leakage as a sign of irritative iritis during the active stage of simple and chronic corneal ulcers, in disciform keratitis, Mooren's ulcer, and in graft rejection [17].

Anatomical context of Iritis


Gene context of Iritis

  • The only significant difference between those patients with an iritis and those with only pelvospondylitis was an elevated CRP in the iritis group (p less than 0.01) [19].
  • RESULTS: Four of the parents had had JIA (one subsequently developed ankylosing spondylitis), and 4 had rheumatoid factor-negative chronic arthritis (one had also had chronic iritis since the age of 10, resembling that seen in JIA) [20].
  • Based on this information the type of uveitis will be named (eg, acute, nongranulomatous, unilateral, anterior uveitis) and matched (meshing) to a potential list of etiologies (eg, viral iritis, HLA-B 27 associated iritis) [21].
  • Analysis of individuals with B27 AS with iritis revealed significant differences in allelic distribution of this biallelic locus compared to patients with B27 AS without iritis [22].
  • When present, antibodies to a 45 kDa protein occur only in sera from children without iritis and not in those with active iritis [23].

Analytical, diagnostic and therapeutic context of Iritis


  1. Acyclovir and vidarabine for the treatment of herpes simplex keratitis. Laibson, P.R., Pavan-Langston, D., Yeakley, W.R., Lass, J. Am. J. Med. (1982) [Pubmed]
  2. Cidofovir: a review of its use in cytomegalovirus retinitis in patients with AIDS. Plosker, G.L., Noble, S. Drugs (1999) [Pubmed]
  3. Autosomal dominant granulomatous arthritis, uveitis, skin rash, and synovial cysts. Pastores, G.M., Michels, V.V., Stickler, G.B., Su, W.P., Nelson, A.M., Bovenmyer, D.A. J. Pediatr. (1990) [Pubmed]
  4. Idiopathic perniosis and its mimics: a clinical and histological study of 38 cases. Crowson, A.N., Magro, C.M. Hum. Pathol. (1997) [Pubmed]
  5. Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycylacyclovir. A water-soluble ester of acyclovir. Maudgal, P.C., De Clercq, K., Descamps, J., Missotten, L. Arch. Ophthalmol. (1984) [Pubmed]
  6. Treatment of cytomegalovirus retinitis with intravitreous cidofovir in patients with AIDS. A preliminary report. Rahhal, F.M., Arevalo, J.F., Chavez de la Paz, E., Munguia, D., Azen, S.P., Freeman, W.R. Ann. Intern. Med. (1996) [Pubmed]
  7. Effect of etanercept on iritis in patients with ankylosing spondylitis. Rosenbaum, J.T. Arthritis Rheum. (2004) [Pubmed]
  8. Acute iritis associated with primary Sjögren's syndrome and high-titer anti-SS-A/Ro and anti-SS-B/La antibodies. Treatment with combination immunosuppressive therapy. Bridges, A.J., Burns, R.P. Arthritis Rheum. (1992) [Pubmed]
  9. Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. Taskintuna, I., Rahhal, F.M., Arevalo, J.F., Munguia, D., Banker, A.S., De Clercq, E., Freeman, W.R. Ophthalmology (1997) [Pubmed]
  10. Anterior nongranulomatous uveitis after intravitreal HPMPC (cidofovir) for the treatment of cytomegalovirus retinitis. Analysis and prevention. Chavez-de la Paz, E., Arevalo, J.F., Kirsch, L.S., Munguia, D., Rahhal, F.M., De Clercq, E., Freeman, W.R. Ophthalmology (1997) [Pubmed]
  11. Herpes simplex keratitis. Kaufman, H.E., Centifanto-Fitzgerald, Y.M., Varnell, E.D. Ophthalmology (1983) [Pubmed]
  12. Clinical performance of Alcon SA30AL and SA60AT single-piece acrylic intraocular lenses. Davison, J.A. Journal of cataract and refractive surgery. (2002) [Pubmed]
  13. Inhibition of prostaglandin-induced iritis. Topical indoxole vs indomethacin therapy. Spinelli, H.M., Krohn, D.L. Arch. Ophthalmol. (1980) [Pubmed]
  14. Cocaine-induced iritis. Wang, E.S. Annals of emergency medicine. (1991) [Pubmed]
  15. Posterior chamber myopia lenses in phakic eyes. Fechner, P.U., Haigis, W., Wichmann, W. Journal of cataract and refractive surgery. (1996) [Pubmed]
  16. Secreted leukocyte protease inhibitor is present in aqueous humours from cataracts and other eye pathologies. Janciauskiene, S., Brandt, L., Wallmark, A., Westin, U., Krakau, T. Exp. Eye Res. (2006) [Pubmed]
  17. Anterior segment fluorescein angiography in inflammatory diseases of the cornea. Saari, K.M. Acta ophthalmologica. (1979) [Pubmed]
  18. Ocular lesions of 6-aminonicotinamide toxicosis in rabbits. Render, J.A., Carlton, W.W. Vet. Pathol. (1985) [Pubmed]
  19. Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. Laurent, M.R., Panayi, G.S. Ann. Rheum. Dis. (1983) [Pubmed]
  20. Occurrence of chronic inflammatory rheumatic diseases among parents of multiple offspring affected by juvenile idiopathic arthritis. Säilä, H., Savolainen, A., Kauppi, M., Alakulppi, N., Tuomilehto-Wolf, E., Tuomilehto, J., Leirisalo-Repo, M., Aho, K. Clinical and experimental rheumatology. (2003) [Pubmed]
  21. An eye on inflammatory eye disease. Kestelyn, P.G. Acta clinica Belgica. (2005) [Pubmed]
  22. Polymorphism in an HLA linked proteasome gene influences phenotypic expression of disease in HLA-B27 positive individuals. Maksymowych, W.P., Wessler, A., Schmitt-Egenolf, M., Suarez-Almazor, M., Ritzel, G., Von Borstel, R.C., Pazderka, F., Russell, A.S. J. Rheumatol. (1994) [Pubmed]
  23. Antinuclear antibody profile in juvenile rheumatoid arthritis. Szer, W., Sierakowska, H., Szer, I.S. J. Rheumatol. (1991) [Pubmed]
  24. Histopathological findings in the iris of dapsone treated leprosy patients. Brandt, F., Zhou, H.M., Shi, Z.R., Rai, N., Thuladar, L., Pradhan, H. The British journal of ophthalmology. (1990) [Pubmed]
  25. Fibrinous iritis due to oxybuprocaine. Haddad, R. The British journal of ophthalmology. (1989) [Pubmed]
  26. Systemic therapy of ocular herpes. Kaufman, H.E. International ophthalmology clinics. (1975) [Pubmed]
  27. Acute granulomatous iritis following 5 fluorouracil therapy for failed trabeculectomy. Mohan, M., Kumar, H., Rana, S. Indian journal of ophthalmology. (1991) [Pubmed]
WikiGenes - Universities