Gene Review:
Ntf5 - neurotrophin 5
Mus musculus
Synonyms:
2900040K06Rik, AI462899, NT-4, NT-5, NT4, ...
- Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development. ElShamy, W.M., Ernfors, P. J. Neurosci. (1997)
- Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway. Hibbert, A.P., Morris, S.J., Seidah, N.G., Murphy, R.A. J. Biol. Chem. (2003)
- Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus. Endres, M., Fan, G., Hirt, L., Jaenisch, R. J. Cereb. Blood Flow Metab. (2003)
- Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Fan, G., Egles, C., Sun, Y., Minichiello, L., Renger, J.J., Klein, R., Liu, G., Jaenisch, R. Nat. Neurosci. (2000)
- Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice. Chi, M.M., Fan, G., Fox, E.A. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2004)
- Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Xie, C.W., Sayah, D., Chen, Q.S., Wei, W.Z., Smith, D., Liu, X. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Neurotrophin-4 is required for tolerance to morphine in the mouse. Smith, D.J., Leil, T.A., Liu, X. Neurosci. Lett. (2003)
- High-fat hyperphagia in neurotrophin-4 deficient mice reveals potential role of vagal intestinal sensory innervation in long-term controls of food intake. Byerly, M.S., Fox, E.A. Neurosci. Lett. (2006)
- Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Klein, R., Smeyne, R.J., Wurst, W., Long, L.K., Auerbach, B.A., Joyner, A.L., Barbacid, M. Cell (1993)
- Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Conover, J.C., Erickson, J.T., Katz, D.M., Bianchi, L.M., Poueymirou, W.T., McClain, J., Pan, L., Helgren, M., Ip, N.Y., Boland, P. Nature (1995)
- Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Liu, X., Ernfors, P., Wu, H., Jaenisch, R. Nature (1995)
- Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Arenas, E., Persson, H. Nature (1994)
- Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle. Nguyen, Q.T., Parsadanian, A.S., Snider, W.D., Lichtman, J.W. Science (1998)
- Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. Gao, W.Q., Zheng, J.L., Karihaloo, M. J. Neurosci. (1995)
- Neurotrophin-4: a survival factor for adult sensory neurons. Stucky, C.L., Shin, J.B., Lewin, G.R. Curr. Biol. (2002)
- Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. Endres, M., Fan, G., Hirt, L., Fujii, M., Matsushita, K., Liu, X., Jaenisch, R., Moskowitz, M.A. J. Cereb. Blood Flow Metab. (2000)
- Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Minichiello, L., Casagranda, F., Tatche, R.S., Stucky, C.L., Postigo, A., Lewin, G.R., Davies, A.M., Klein, R. Neuron (1998)
- A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., Bulfone-Paus, S., Hagen, E., Braun, A., Lommatzsch, M., Renz, H., Paus, A.R. FASEB J. (1999)
- Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Liebl, D.J., Klesse, L.J., Tessarollo, L., Wohlman, T., Parada, L.F. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors. Stucky, C.L., DeChiara, T., Lindsay, R.M., Yancopoulos, G.D., Koltzenburg, M. J. Neurosci. (1998)
- Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin. Botchkarev, V.A., Metz, M., Botchkareva, N.V., Welker, P., Lommatzsch, M., Renz, H., Paus, R. Lab. Invest. (1999)
- Interaction of NT-4 and BDNF with gp145trkb receptor: effect on cellular metabolism. Hopkins, M.A., Rosser, M.P., Fernandes, P.B., Bursuker, I. J. Neurosci. Methods (1997)
- Role of neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo. Harada, C., Harada, T., Quah, H.M., Namekata, K., Yoshida, K., Ohno, S., Tanaka, K., Parada, L.F. Invest. Ophthalmol. Vis. Sci. (2005)
- NR2A induction and NMDA receptor-dependent neuronal death by neurotrophin-4/5 in cortical cell culture. Choi, S.Y., Hwang, J.J., Koh, J.Y. J. Neurochem. (2004)
- Synthesis and cytotoxic profile of a diphtheria toxin-neurotrophin-4 chimera. Negro, A., Skaper, S.D. J. Neurochem. (1997)
- Immunohistochemical detection of neurotrophin-3 and -4, and their receptors in mouse taste bud cells. Takeda, M., Suzuki, Y., Obara, N., Tsunekawa, H. Arch. Histol. Cytol. (2005)
- Pro-inflammatory cytokines upregulate the skin immunoreactivity for NGF, NT-3, NT-4 and their receptor, p75NTR in vivo: a preliminary report. Bläsing, H., Hendrix, S., Paus, R. Arch. Dermatol. Res. (2005)
- TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis. Seil, F.J., Drake-Baumann, R. J. Neurosci. (2000)
- Attenuation of a caspase-3 dependent cell death in NT4- and p75-deficient embryonic sensory neurons. Agerman, K., Baudet, C., Fundin, B., Willson, C., Ernfors, P. Mol. Cell. Neurosci. (2000)
- Neurotrophin-4/5 is required for the early growth of regenerating axons in peripheral nerves. English, A.W., Meador, W., Carrasco, D.I. Eur. J. Neurosci. (2005)
- BDNF but not NT-4 is required for normal flexion reflex plasticity and function. Heppenstall, P.A., Lewin, G.R. Proc. Natl. Acad. Sci. U.S.A. (2001)