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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Tocolysis


High impact information on Tocolysis

  • These findings suggest that premature fetal DA closure or neonatal patent DA observed following indomethacin tocolysis in women may result from the inhibition of COX-2 [6].
  • Nineteen patients had received no tocolysis (controls, group I) and 21 had been treated with fenoterol (<48 h in 10, group II; > or = 48 h in 11, group III) [7].
  • Intravenous tocolysis with the beta2-adrenergic receptor agonist fenoterol leads to complete desensitization of the beta-adrenergic receptor system [7].
  • Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling [7].
  • In contrast, only 37 of 50 women carrying 1 or 2 glycine alleles (74%) had delivery delayed by more than 48 hours with tocolysis [8].

Chemical compound and disease context of Tocolysis


Biological context of Tocolysis


Anatomical context of Tocolysis


Associations of Tocolysis with chemical compounds


Gene context of Tocolysis

  • Accordingly, coapplication of a selective PDE4 inhibitor might greatly improve the usefulness of beta-mimetic in tocolysis [29].
  • In women who had failed tocolysis, discriminatory concentrations of IL-6 and IL-8 were 20 and 15 ng/mL, respectively [30].
  • The role of oxytocin receptors and vasopressin V1a receptors in uterine contractions in rats: implications for tocolytic therapy with oxytocin antagonists [31].
  • This study describes an effective and selective noncompetitive FP antagonist, THG113, which significantly delays preterm delivery; this provides the basis for future investigations for its use in tocolysis [32].
  • In view of observations indicating accelerated fetal pulmonary maturation after tocolytic therapy with beta-adrenergic agonists, this study was undertaken to determine whether the phenomenon is related to enhanced maternal or fetal ACTH, cortisol or prolactin secretion [33].

Analytical, diagnostic and therapeutic context of Tocolysis


  1. Nifedipine block of capacitative calcium entry in cultured human uterine smooth-muscle cells. Young, R.C., Schumann, R., Zhang, P. J. Soc. Gynecol. Investig. (2001) [Pubmed]
  2. The efficacy of oral terbutaline after intravenous tocolysis. Parilla, B.V., Dooley, S.L., Minogue, J.P., Socol, M.L. Am. J. Obstet. Gynecol. (1993) [Pubmed]
  3. Influence of the beta-1 selective blocker, metoprolol, on the development of pulmonary edema in tocolytic therapy. Strigl, R., Pfeiffer, U., Aschenbrenner, G., Blümel, G. Obstetrics and gynecology. (1986) [Pubmed]
  4. Indomethacin tocolysis and intraventricular hemorrhage. Suarez, R.D., Grobman, W.A., Parilla, B.V. Obstetrics and gynecology. (2001) [Pubmed]
  5. Indomethacin tocolysis and risk of necrotizing enterocolitis. Parilla, B.V., Grobman, W.A., Holtzman, R.B., Thomas, H.A., Dooley, S.L. Obstetrics and gynecology. (2000) [Pubmed]
  6. Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus. Loftin, C.D., Trivedi, D.B., Langenbach, R. J. Clin. Invest. (2002) [Pubmed]
  7. Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncoupling. Frambach, T., Müller, T., Freund, S., Engelhardt, S., Sütterlin, M., Lohse, M.J., Dietl, J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  8. Arg16 homozygosity of the beta2-adrenergic receptor improves the outcome after beta2-agonist tocolysis for preterm labor. Landau, R., Morales, M.A., Antonarakis, S.E., Blouin, J.L., Smiley, R.M. Clin. Pharmacol. Ther. (2005) [Pubmed]
  9. Oral ritodrine maintenance in the treatment of preterm labor. Creasy, R.K., Golbus, M.S., Laros, R.K., Parer, J.T., Roberts, J.M. Am. J. Obstet. Gynecol. (1980) [Pubmed]
  10. Long-term use of magnesium sulfate as a tocolytic agent. Wilkins, I.A., Goldberg, J.D., Phillips, R.N., Bacall, C.J., Chervenak, F.A., Berkowitz, R.L. Obstetrics and gynecology. (1986) [Pubmed]
  11. The effect of short-term indomethacin therapy on amniotic fluid volume. Sandruck, J.C., Grobman, W.A., Gerber, S.E. Am. J. Obstet. Gynecol. (2005) [Pubmed]
  12. Oral terbutaline after parenteral tocolysis: a randomized, double-blind, placebo-controlled trial. Lewis, R., Mercer, B.M., Salama, M., Walsh, M.A., Sibai, B.M. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  13. Terbutaline pump maintenance therapy for prevention of preterm delivery: a double-blind trial. Guinn, D.A., Goepfert, A.R., Owen, J., Wenstrom, K.D., Hauth, J.C. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  14. Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium. Engelhardt, S., Zieger, W., Kassubek, J., Michel, M.C., Lohse, M.J., Brodde, O.E. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  15. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. Braden, G.L., von Oeyen, P.T., Germain, M.J., Watson, D.J., Haag, B.L. Kidney Int. (1997) [Pubmed]
  16. Oligohydramnios in each sac of a triplet gestation caused by Motrin--fulfilling Kock's postulates. Wiggins, D.A., Elliott, J.P. Am. J. Obstet. Gynecol. (1990) [Pubmed]
  17. Oral terbutaline in the outpatient management of preterm labor. How, H.Y., Hughes, S.A., Vogel, R.L., Gall, S.A., Spinnato, J.A. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  18. Cardiovascular and metabolic effects associated with nifedipine and ritodrine tocolysis. Ferguson, J.E., Dyson, D.C., Holbrook, R.H., Schutz, T., Stevenson, D.K. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  19. Metabolic effects of ritodrine in the fetal lamb. van der Weyde, M.P., Wright, M.R., Taylor, S.M., Axelson, J.E., Rurak, D.W. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  20. The effect of magnesium sulfate tocolysis on the fetal biophysical profile. Peaceman, A.M., Meyer, B.A., Thorp, J.A., Parisi, V.M., Creasy, R.K. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  21. Short-term outcomes in low birth weight infants following antenatal exposure to betamethasone versus dexamethasone. Bar-Lev, M.R., Maayan-Metzger, A., Matok, I., Heyman, Z., Sivan, E., Kuint, J. Obstetrics and gynecology. (2004) [Pubmed]
  22. The effects of nifedipine on pregnancy outcome and morphology of the placenta, uterus, and cervix during late pregnancy in the rat. Richichi, J., Vasilenko, P. Am. J. Obstet. Gynecol. (1992) [Pubmed]
  23. Efficacy and safety of indomethacin versus ritodrine in the management of preterm labor: a randomized study. Morales, W.J., Smith, S.G., Angel, J.L., O'Brien, W.F., Knuppel, R.A. Obstetrics and gynecology. (1989) [Pubmed]
  24. Suppression of preterm labour. Current concepts. Johnson, P. Drugs (1993) [Pubmed]
  25. Congenital rickets associated with magnesium sulfate infusion for tocolysis. Lamm, C.I., Norton, K.I., Murphy, R.J., Wilkins, I.A., Rabinowitz, J.G. J. Pediatr. (1988) [Pubmed]
  26. Neonatal hypoglycemia after beta-sympathomimetic tocolytic therapy. Epstein, M.F., Nicholls, E., Stubblefield, P.G. J. Pediatr. (1979) [Pubmed]
  27. Tocolysis with nifedipine or beta-adrenergic agonists: a meta-analysis. Tsatsaris, V., Papatsonis, D., Goffinet, F., Dekker, G., Carbonne, B. Obstetrics and gynecology. (2001) [Pubmed]
  28. Predicting delivery within 48 hours in women treated with parenteral tocolysis. Macones, G.A., Segel, S.Y., Stamilio, D.M., Morgan, M.A. Obstetrics and gynecology. (1999) [Pubmed]
  29. Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? Méhats, C., Tanguy, G., Dallot, E., Cabrol, D., Ferré, F., Leroy, M.J. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  30. Amniotic fluid interleukin-6 and interleukin-8 levels predict the success of tocolysis in patients with preterm labor. Allbert, J.R., Naef, R.W., Perry, K.G., Magann, E.F., Whitworth, N.S., Morrison, J.C. J. Soc. Gynecol. Investig. (1994) [Pubmed]
  31. The role of oxytocin receptors and vasopressin V1a receptors in uterine contractions in rats: implications for tocolytic therapy with oxytocin antagonists. Chan, W.Y., Wo, N.C., Manning, M. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  32. THG113: a novel selective FP antagonist that delays preterm labor. Peri, K.G., Quiniou, C., Hou, X., Abran, D., Varma, D.R., Lubell, W.D., Chemtob, S. Semin. Perinatol. (2002) [Pubmed]
  33. Maternal, fetal and aminiotic fluid ACTH, cortisol and prolactin in association with medical beta-adrenergic stimulation. Kauppila, A., Jouppila, R., Moilanen, K., Pakarinen, A., Tuimala, R. British journal of obstetrics and gynaecology. (1981) [Pubmed]
  34. Outpatient triplet management: a contemporary review. Newman, R.B., Hamer, C., Miller, M.C. Am. J. Obstet. Gynecol. (1989) [Pubmed]
  35. Randomized comparison of intravenous nitroglycerin and subcutaneous terbutaline for external cephalic version under tocolysis. El-Sayed, Y.Y., Pullen, K., Riley, E.T., Lyell, D., Druzin, M.L., Cohen, S.E., Chitkara, U. Am. J. Obstet. Gynecol. (2004) [Pubmed]
  36. The effect of indomethacin tocolysis on fetal ductus arteriosus constriction with advancing gestational age. Vermillion, S.T., Scardo, J.A., Lashus, A.G., Wiles, H.B. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  37. A randomized double-dummy comparison between indomethacin and nylidrin in threatened preterm labor. Kurki, T., Eronen, M., Lumme, R., Ylikorkala, O. Obstetrics and gynecology. (1991) [Pubmed]
  38. Cardiovascular effects of ritodrine tocolysis: a new noninvasive method to measure pulmonary capillary pressure during pregnancy. Hadi, H.A., Abdulla, A.M., Fadel, H.E., Stefadouros, M.A., Metheny, W.P. Obstetrics and gynecology. (1987) [Pubmed]
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