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Chemical Compound Review

AG-H-07712     iron(+3) cation trichloride

Synonyms: AG-L-18181, DSSTox_CID_622, AC1L4XPF, AC1Q1RLZ, CTK5I1099, ...
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Disease relevance of FERRIC CHLORIDE


Psychiatry related information on FERRIC CHLORIDE

  • Reaction of carbaporphyrin 4a with aqueous ferric chloride afforded the corresponding 21-chloro derivative 20 in good yields, and at longer reaction times a nonaromatic dione was isolated [6].

High impact information on FERRIC CHLORIDE


Chemical compound and disease context of FERRIC CHLORIDE


Biological context of FERRIC CHLORIDE


Anatomical context of FERRIC CHLORIDE


Associations of FERRIC CHLORIDE with other chemical compounds


Gene context of FERRIC CHLORIDE

  • The recent observation that knock-out of protease-activated receptor-4 (PAR4) ablates thrombin signaling in mouse platelets and protects against ferric chloride-induced thrombosis of mouse mesenteric arterioles suggests that thrombin's actions on platelets can play an important role in thrombosis [2].
  • METHODS AND RESULTS: Platelet-rich thrombi were induced in wild-type mice (PAI-1 +/+; n=11) and PAI-1-deficient mice (PAI-1 -/-; n=11) with ferric chloride [31].
  • METHODS AND RESULTS: Wild-type mice placed on an atherogenic, high-fat diet had elevated (9-fold) leptin levels compared with their counterparts maintained on normal chow, and the former demonstrated significantly enhanced neointimal thickening after carotid artery injury with ferric chloride [32].
  • METHODS AND RESULTS: We used the ferric chloride model to induce carotid artery injury in apolipoprotein E knockout (apoE-/-) and wild-type (WT) mice [33].
  • Taken together, these data indicated that local VSMC-specific TFPI overexpression attenuated ferric chloride-induced thrombosis without systemic or hemostatic effects [4].

Analytical, diagnostic and therapeutic context of FERRIC CHLORIDE


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  6. Regioselective oxidations of benzocarbaporphyrins with ferric chloride: a facile synthesis of bridged [18]annulene ketals with strong absorptions in the far red and an unexpected halogenation reaction at the interior carbon atom. Lash, T.D., Muckey, M.A., Hayes, M.J., Liu, D., Spence, J.D., Ferrence, G.M. J. Org. Chem. (2003) [Pubmed]
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  9. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Denis, C., Methia, N., Frenette, P.S., Rayburn, H., Ullman-Culleré, M., Hynes, R.O., Wagner, D.D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Liu, J., Fitzgerald, M.E., Berndt, M.C., Jackson, C.W., Gartner, T.K. Blood (2006) [Pubmed]
  11. Platelet PECAM-1 inhibits thrombus formation in vivo. Falati, S., Patil, S., Gross, P.L., Stapleton, M., Merrill-Skoloff, G., Barrett, N.E., Pixton, K.L., Weiler, H., Cooley, B., Newman, D.K., Newman, P.J., Furie, B.C., Furie, B., Gibbins, J.M. Blood (2006) [Pubmed]
  12. Pharmacological characterization of N-tert-butyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea (BM-573), a novel thromboxane A2 receptor antagonist and thromboxane synthase inhibitor in a rat model of arterial thrombosis and its effects on bleeding time. Dogné, J.M., Hanson, J., de Leval, X., Kolh, P., Tchana-Sato, V., de Leval, L., Rolin, S., Ghuysen, A., Segers, P., Lambermont, B., Masereel, B., Pirotte, B. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  13. Effects of iron and deferoxamine on cisplatin-induced emesis: further evidence for the role of free radicals. Matsuki, N., Torii, Y., Saito, H. Eur. J. Pharmacol. (1993) [Pubmed]
  14. Ultrastructural study of the long-term development of two experimental cutaneous calcinoses (topical calciphylaxis and topical calcergy) in the rat. Boivin, G., Walzer, C., Baud, C.A. Cell Tissue Res. (1987) [Pubmed]
  15. Cytogenetic, developmental, and biochemical effects of aluminum, iron, and their mixture in sea urchins and mussels. Pagano, G., His, E., Beiras, R., De Biase, A., Korkina, L.G., Iaccarino, M., Oral, R., Quiniou, F., Warnau, M., Trieff, N.M. Arch. Environ. Contam. Toxicol. (1996) [Pubmed]
  16. Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Hsieh, C.L., Chang, C.H., Chiang, S.Y., Li, T.C., Tang, N.Y., Pon, C.Z., Hsieh, C.T., Lin, J.G. Life Sci. (2000) [Pubmed]
  17. Platelet P-selectin plays an important role in arterial thrombogenesis by forming large stable platelet-leukocyte aggregates. Yokoyama, S., Ikeda, H., Haramaki, N., Yasukawa, H., Murohara, T., Imaizumi, T. J. Am. Coll. Cardiol. (2005) [Pubmed]
  18. Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Hussain, S.P., Aguilar, F., Amstad, P., Cerutti, P. Oncogene (1994) [Pubmed]
  19. Rapid, colorimetric test for the determination of hippurate hydrolysis by group B Streptococcus. Edberg, S.C., Samuels, S. J. Clin. Microbiol. (1976) [Pubmed]
  20. Serum iron curves can be used to estimate dietary iron bioavailability in humans. Conway, R.E., Geissler, C.A., Hider, R.C., Thompson, R.P., Powell, J.J. J. Nutr. (2006) [Pubmed]
  21. Molecular characterization of the iron-hydroxamate uptake system in Staphylococcus aureus. Cabrera, G., Xiong, A., Uebel, M., Singh, V.K., Jayaswal, R.K. Appl. Environ. Microbiol. (2001) [Pubmed]
  22. Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglobin. Fibach, E., Kollia, P., Schechter, A.N., Noguchi, C.T., Rodgers, G.P. Blood (1995) [Pubmed]
  23. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Campagnolo, L., Leahy, A., Chitnis, S., Koschnick, S., Fitch, M.J., Fallon, J.T., Loskutoff, D., Taubman, M.B., Stuhlmann, H. Am. J. Pathol. (2005) [Pubmed]
  24. Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures. Csernansky, J.G., Csernansky, C.A., Bonnet, K.A., Hollister, L.E. Biol. Psychiatry (1985) [Pubmed]
  25. High affinity (3H) beta-alanine uptake by scar margins of ferric chloride-induced epileptogenic foci in rat isocortex. Robitaille, Y., Sherwin, A. J. Neuropathol. Exp. Neurol. (1984) [Pubmed]
  26. Amino acid-specific ADP-ribosylation. Moss, J., Yost, D.A., Stanley, S.J. J. Biol. Chem. (1983) [Pubmed]
  27. The effect of raw wheat bran, alfalfa meal and alpha-cellulose on iron ascorbate chelate and ferric chloride in three binding solutions. Mackler, B.P., Herbert, V. Am. J. Clin. Nutr. (1985) [Pubmed]
  28. Impairment of blastogenic response of splenic lymphocytes from iron-deficient mice. In vitro repletion by hemin, transferrin, and ferric chloride. Kuvibidila, S.R., Nauss, K.M., Baliga, S.B., Suskind, R.M. Am. J. Clin. Nutr. (1983) [Pubmed]
  29. Simple fluorometric determination of aldosterone in urine without use of isotopes or chromatography. Whigham, W.R. Clin. Chem. (1976) [Pubmed]
  30. Effects of sample aging on total cholesterol values determined by the automated ferric chloride-sulfuric acid and Liebermann-Burchard procedures. Wood, P.D., Bachorik, P.S., Albers, J.J., Stewart, C.C., Winn, C., Lippel, K. Clin. Chem. (1980) [Pubmed]
  31. Plasminogen activator inhibitor-1 is a major determinant of arterial thrombolysis resistance. Zhu, Y., Carmeliet, P., Fay, W.P. Circulation (1999) [Pubmed]
  32. Leptin promotes vascular remodeling and neointimal growth in mice. Schäfer, K., Halle, M., Goeschen, C., Dellas, C., Pynn, M., Loskutoff, D.J., Konstantinides, S. Arterioscler. Thromb. Vasc. Biol. (2004) [Pubmed]
  33. Enhanced thrombosis in atherosclerosis-prone mice is associated with increased arterial expression of plasminogen activator inhibitor-1. Schafer, K., Müller, K., Hecke, A., Mounier, E., Goebel, J., Loskutoff, D.J., Konstantinides, S. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  34. New phosphate binding agents: ferric compounds. Hsu, C.H., Patel, S.R., Young, E.W. J. Am. Soc. Nephrol. (1999) [Pubmed]
  35. Reversal of meconium inhibition of pulmonary surfactant by ferric chloride, copper chloride, and acetic acid. Almaas, R., Robertson, B., Linderholm, B., Lundberg, E., Saugstad, O.D., Moen, A. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  36. Innocent and less-innocent solvent ligands: a systematic investigation of cationic iron chloride/alcohol complexes by electrospray ionization mass spectrometry complemented by DFT calculations. Trage, C., Diefenbach, M., Schröder, D., Schwarz, H. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
  37. Melanogenuria: laboratory evaluation of the qualitative Thormählen and ferric chloride tests and their clinical utility. Scott, R.E., Ward, V.L., Grinstead, G.F., Stevens, B.S., Wilson, D.M. Clin. Chem. (1988) [Pubmed]
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