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Chemical Compound Review

AG-H-07712     iron(+3) cation trichloride

Synonyms: AG-L-18181, DSSTox_CID_622, AC1L4XPF, AC1Q1RLZ, CTK5I1099, ...
 
 
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Disease relevance of FERRIC CHLORIDE

 

Psychiatry related information on FERRIC CHLORIDE

  • Reaction of carbaporphyrin 4a with aqueous ferric chloride afforded the corresponding 21-chloro derivative 20 in good yields, and at longer reaction times a nonaromatic dione was isolated [6].
 

High impact information on FERRIC CHLORIDE

 

Chemical compound and disease context of FERRIC CHLORIDE

 

Biological context of FERRIC CHLORIDE

 

Anatomical context of FERRIC CHLORIDE

 

Associations of FERRIC CHLORIDE with other chemical compounds

 

Gene context of FERRIC CHLORIDE

  • The recent observation that knock-out of protease-activated receptor-4 (PAR4) ablates thrombin signaling in mouse platelets and protects against ferric chloride-induced thrombosis of mouse mesenteric arterioles suggests that thrombin's actions on platelets can play an important role in thrombosis [2].
  • METHODS AND RESULTS: Platelet-rich thrombi were induced in wild-type mice (PAI-1 +/+; n=11) and PAI-1-deficient mice (PAI-1 -/-; n=11) with ferric chloride [31].
  • METHODS AND RESULTS: Wild-type mice placed on an atherogenic, high-fat diet had elevated (9-fold) leptin levels compared with their counterparts maintained on normal chow, and the former demonstrated significantly enhanced neointimal thickening after carotid artery injury with ferric chloride [32].
  • METHODS AND RESULTS: We used the ferric chloride model to induce carotid artery injury in apolipoprotein E knockout (apoE-/-) and wild-type (WT) mice [33].
  • Taken together, these data indicated that local VSMC-specific TFPI overexpression attenuated ferric chloride-induced thrombosis without systemic or hemostatic effects [4].
 

Analytical, diagnostic and therapeutic context of FERRIC CHLORIDE

References

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