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Gene Review

Tnfrsf17  -  tumor necrosis factor receptor superfamily...

Mus musculus

Synonyms: B-cell maturation protein, BCM, BCMA, Bcm, Bcma, ...
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Disease relevance of Tnfrsf17


High impact information on Tnfrsf17


Chemical compound and disease context of Tnfrsf17


Biological context of Tnfrsf17


Anatomical context of Tnfrsf17


Associations of Tnfrsf17 with chemical compounds


Physical interactions of Tnfrsf17

  • Moreover, we show that, in contrast to monovalent BAFF-R-Fc, monovalent BCMA does not form stable complexes with BAFF [25].
  • The analysis of the two types of gamma 2b transgenic mice shows that the signals for preB cell development are highly complex and promises to reveal new insights into the molecular and cellular mechanisms of B cell maturation [26].

Regulatory relationships of Tnfrsf17


Other interactions of Tnfrsf17

  • Heightened expression of B cell maturation antigen (BCMA), and lowered expression of transmembrane activator and cyclophilin ligand interactor and BAFF receptor in PCs relative to resting B cells suggests a vital role of BCMA in PC survival [18].
  • Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation [15].
  • NF-kappaB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells [31].
  • RelB, another member of the NF-kappa B/Rel family of transcription factors, is expressed during the latter stages of B cell maturation and can bind to regulatory sites within the Ig heavy chain locus [16].
  • These findings (taken in conjunction with the previously described immune defects in CBA/N mice and other studies of B-cell maturation) suggest to us that Lyb3 is a cell surface component expressed selectively on a mature B-cell subclass [32].

Analytical, diagnostic and therapeutic context of Tnfrsf17


  1. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Gross, J.A., Dillon, S.R., Mudri, S., Johnston, J., Littau, A., Roque, R., Rixon, M., Schou, O., Foley, K.P., Haugen, H., McMillen, S., Waggie, K., Schreckhise, R.W., Shoemaker, K., Vu, T., Moore, M., Grossman, A., Clegg, C.H. Immunity (2001) [Pubmed]
  2. The characterization of murine BCMA gene defines it as a new member of the tumor necrosis factor receptor superfamily. Madry, C., Laabi, Y., Callebaut, I., Roussel, J., Hatzoglou, A., Le Coniat, M., Mornon, J.P., Berger, R., Tsapis, A. Int. Immunol. (1998) [Pubmed]
  3. An expanded population of natural killer cells in mice with severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes. Lauzon, R.J., Siminovitch, K.A., Fulop, G.M., Phillips, R.A., Roder, J.C. J. Exp. Med. (1986) [Pubmed]
  4. CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus. Mihara, M., Tan, I., Chuzhin, Y., Reddy, B., Budhai, L., Holzer, A., Gu, Y., Davidson, A. J. Clin. Invest. (2000) [Pubmed]
  5. Substance P receptor antagonist inhibits murine IgM expression in developing schistosome granulomas by blocking the terminal differentiation of intragranuloma B cells. Blum, A., Metwali, A., Elliott, D., Sandor, M., Lynch, R., Weinstock, J.V. J. Neuroimmunol. (1996) [Pubmed]
  6. Thymocyte apoptosis induced by p53-dependent and independent pathways. Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H. Nature (1993) [Pubmed]
  7. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Adams, J.M., Harris, A.W., Pinkert, C.A., Corcoran, L.M., Alexander, W.S., Cory, S., Palmiter, R.D., Brinster, R.L. Nature (1985) [Pubmed]
  8. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Schiemann, B., Gommerman, J.L., Vora, K., Cachero, T.G., Shulga-Morskaya, S., Dobles, M., Frew, E., Scott, M.L. Science (2001) [Pubmed]
  9. Aberrant B cell development and immune response in mice with a compromised BCR complex. Torres, R.M., Flaswinkel, H., Reth, M., Rajewsky, K. Science (1996) [Pubmed]
  10. Requirement for NF-kappaB in osteoclast and B-cell development. Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E.W., Brown, K.D., Leonardi, A., Tran, T., Boyce, B.F., Siebenlist, U. Genes Dev. (1997) [Pubmed]
  11. Induction of malignant lymphomas in swiss mice by n-nitroso compounds formed in vivo. Börzsönyi, M., Csik, M. Int. J. Cancer (1975) [Pubmed]
  12. Lymphokine-like activity of a strain of Mycoplasma arginini. Ruuth, E., Wieslander, A., Persson, H., Friedrich, B., Lundgren, E. Isr. J. Med. Sci. (1984) [Pubmed]
  13. B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells. Yang, M., Hase, H., Legarda-Addison, D., Varughese, L., Seed, B., Ting, A.T. J. Immunol. (2005) [Pubmed]
  14. B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Xu, S., Lam, K.P. Mol. Cell. Biol. (2001) [Pubmed]
  15. Double knockout mice show BASH and PKCdelta have different epistatic relationships in B cell maturation and CD40-mediated activation. Nojima, T., Hayashi, K., Goitsuka, R., Nakayama, K., Nakayama, K., Kitamura, D. Immunol. Lett. (2006) [Pubmed]
  16. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. Snapper, C.M., Rosas, F.R., Zelazowski, P., Moorman, M.A., Kehry, M.R., Bravo, R., Weih, F. J. Exp. Med. (1996) [Pubmed]
  17. Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. Lentz, V.M., Cancro, M.P., Nashold, F.E., Hayes, C.E. J. Immunol. (1996) [Pubmed]
  18. BCMA is essential for the survival of long-lived bone marrow plasma cells. O'Connor, B.P., Raman, V.S., Erickson, L.D., Cook, W.J., Weaver, L.K., Ahonen, C., Lin, L.L., Mantchev, G.T., Bram, R.J., Noelle, R.J. J. Exp. Med. (2004) [Pubmed]
  19. Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes. Kim, H.S., Zhang, X., Choi, Y.S. J. Immunol. (1994) [Pubmed]
  20. Activation and accumulation of B cells in TACI-deficient mice. Yan, M., Wang, H., Chan, B., Roose-Girma, M., Erickson, S., Baker, T., Tumas, D., Grewal, I.S., Dixit, V.M. Nat. Immunol. (2001) [Pubmed]
  21. Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice. de Jonge, W.J., Kwikkers, K.L., te Velde, A.A., van Deventer, S.J., Nolte, M.A., Mebius, R.E., Ruijter, J.M., Lamers, M.C., Lamers, W.H. J. Clin. Invest. (2002) [Pubmed]
  22. Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity. Matza, D., Lantner, F., Bogoch, Y., Flaishon, L., Hershkoviz, R., Shachar, I. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  23. Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation. Luster, M.I., Germolec, D.R., Clark, G., Wiegand, G., Rosenthal, G.J. J. Immunol. (1988) [Pubmed]
  24. B lymphocyte differentiation induced by lipopolysaccharide. III. Suppression of B cell maturation by anti-mouse immunoglobulin antibodies. Kearney, J.F., Cooper, M.D., Lawton, A.R. J. Immunol. (1976) [Pubmed]
  25. Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. Pelletier, M., Thompson, J.S., Qian, F., Bixler, S.A., Gong, D., Cachero, T., Gilbride, K., Day, E., Zafari, M., Benjamin, C., Gorelik, L., Whitty, A., Kalled, S.L., Ambrose, C., Hsu, Y.M. J. Biol. Chem. (2003) [Pubmed]
  26. Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Storb, U., Roth, P., Kurtz, B.K. Immunol. Res. (1994) [Pubmed]
  27. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. Nishina, H., Bachmann, M., Oliveira-dos-Santos, A.J., Kozieradzki, I., Fischer, K.D., Odermatt, B., Wakeham, A., Shahinian, A., Takimoto, H., Bernstein, A., Mak, T.W., Woodgett, J.R., Ohashi, P.S., Penninger, J.M. J. Exp. Med. (1997) [Pubmed]
  28. Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. Jin, H., Carrio, R., Yu, A., Malek, T.R. J. Immunol. (2004) [Pubmed]
  29. Inhibition of B lymphocyte activation by interferon-gamma. Reynolds, D.S., Boom, W.H., Abbas, A.K. J. Immunol. (1987) [Pubmed]
  30. Distinction of B cell maturation factors from lymphokines affecting B cell growth and viability. Sherris, D.I., Sidman, C.L. J. Immunol. (1986) [Pubmed]
  31. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W., French, D.M., Grewal, I.S., Cochran, A.G., Gordon, N.C., Yin, J., Starovasnik, M.A., Dixit, V.M. Immunity (2002) [Pubmed]
  32. Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice. Huber, B., Gershon, R.K., Cantor, H. J. Exp. Med. (1977) [Pubmed]
  33. Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence. Hardy, R.R., Hayakawa, K., Parks, D.R., Herzenberg, L.A. Nature (1983) [Pubmed]
  34. Natural killer cells induce activated murine B cells to secrete Ig. Snapper, C.M., Yamaguchi, H., Moorman, M.A., Sneed, R., Smoot, D., Mond, J.J. J. Immunol. (1993) [Pubmed]
  35. Regulation of Pancreatic {beta}-Cell Regeneration in the Normoglycemic 60% Partial-Pancreatectomy Mouse. Peshavaria, M., Larmie, B.L., Lausier, J., Satish, B., Habibovic, A., Roskens, V., Larock, K., Everill, B., Leahy, J.L., Jetton, T.L. Diabetes (2006) [Pubmed]
  36. In vivo blockage of B cell maturation by splenic T cells of total lymphoid irradiated mice. Zan-Bar, I. Eur. J. Immunol. (1984) [Pubmed]
  37. Synergistic effect of anti-T cell receptor monoclonal antibody and 15-deoxyspergualin on cardiac xenograft survival in a mouse-to-rat model. Haga, M., Tsuchida, M., Hirahara, H., Watanabe, T., Hayashi, J.I., Watanabe, H., Matsumoto, Y., Abo, T., Eguchi, S. Transplantation (2000) [Pubmed]
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