Gene Review:
DMBT1 - deleted in malignant brain tumors 1
Homo sapiens
Synonyms:
Deleted in malignant brain tumors 1 protein, GP340, Glycoprotein 340, Gp-340, Hensin, ...
- Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter. Fujisawa, H., Kurrer, M., Reis, R.M., Yonekawa, Y., Kleihues, P., Ohgaki, H. Am. J. Pathol. (1999)
- Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance. Lin, H., Bondy, M.L., Langford, L.A., Hess, K.R., Delclos, G.L., Wu, X., Chan, W., Pershouse, M.A., Yung, W.K., Steck, P.A. Clin. Cancer Res. (1998)
- Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Sasaki, M., Tsuneyama, K., Saito, T., Kataoka, H., Mollenhauer, J., Poustka, A., Nakanuma, Y. Liver Int. (2004)
- DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Mollenhauer, J., Wiemann, S., Scheurlen, W., Korn, B., Hayashi, Y., Wilgenbus, K.K., von Deimling, A., Poustka, A. Nat. Genet. (1997)
- DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancer. Mollenhauer, J., Herbertz, S., Holmskov, U., Tolnay, M., Krebs, I., Merlo, A., Schrøder, H.D., Maier, D., Breitling, F., Wiemann, S., Gröne, H.J., Poustka, A. Cancer Res. (2000)
- Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Holmskov, U., Mollenhauer, J., Madsen, J., Vitved, L., Gronlund, J., Tornoe, I., Kliem, A., Reid, K.B., Poustka, A., Skjodt, K. Proc. Natl. Acad. Sci. U.S.A. (1999)
- P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Laszik, Z., Jansen, P.J., Cummings, R.D., Tedder, T.F., McEver, R.P., Moore, K.L. Blood (1996)
- Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Bisgaard, H.C., Holmskov, U., Santoni-Rugiu, E., Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, K., Rasmussen, L.J., Tygstrup, N. Am. J. Pathol. (2002)
- Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas. Maier, D., Zhang, Z., Taylor, E., Hamou, M.F., Gratzl, O., Van Meir, E.G., Scott, R.J., Merlo, A. Oncogene (1998)
- Functional and molecular analyses of 10q deletions in human gliomas. Steck, P.A., Lin, H., Langford, L.A., Jasser, S.A., Koul, D., Yung, W.K., Pershouse, M.A. Genes Chromosomes Cancer (1999)
- Expression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer. Wu, W., Kemp, B.L., Proctor, M.L., Gazdar, A.F., Minna, J.D., Hong, W.K., Mao, L. Cancer Res. (1999)
- Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancer. Mollenhauer, J., Herbertz, S., Helmke, B., Kollender, G., Krebs, I., Madsen, J., Holmskov, U., Sorger, K., Schmitt, L., Wiemann, S., Otto, H.F., Gröne, H.J., Poustka, A. Cancer Res. (2001)
- The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Tynan, S., Pacia, E., Haynes-Johnson, D., Lawrence, D., D'Andrea, M.R., Guo, J.Z., Lundeen, S., Allan, G. Endocrinology (2005)
- Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer. Mollenhauer, J., Deichmann, M., Helmke, B., Müller, H., Kollender, G., Holmskov, U., Ligtenberg, T., Krebs, I., Wiemann, S., Bantel-Schaal, U., Madsen, J., Bikker, F., Klauck, S.M., Otto, H.F., Moldenhauer, G., Poustka, A. Int. J. Cancer (2003)
- Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner. Tino, M.J., Wright, J.R. Am. J. Respir. Cell Mol. Biol. (1999)
- Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340. Prakobphol, A., Xu, F., Hoang, V.M., Larsson, T., Bergstrom, J., Johansson, I., Frängsmyr, L., Holmskov, U., Leffler, H., Nilsson, C., Borén, T., Wright, J.R., Strömberg, N., Fisher, S.J. J. Biol. Chem. (2000)
- Binding of salivary agglutinin to IgA. Ligtenberg, A.J., Bikker, F.J., De Blieck-Hogervorst, J.M., Veerman, E.C., Nieuw Amerongen, A.V. Biochem. J. (2004)
- Lung and salivary scavenger receptor glycoprotein-340 contribute to the host defense against influenza A viruses. Hartshorn, K.L., White, M.R., Mogues, T., Ligtenberg, T., Crouch, E., Holmskov, U. Am. J. Physiol. Lung Cell Mol. Physiol. (2003)
- Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. Fuller, C.E., Schmidt, R.E., Roth, K.A., Burger, P.C., Scheithauer, B.W., Banerjee, R., Trinkaus, K., Lytle, R., Perry, A. J. Neuropathol. Exp. Neurol. (2003)
- Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines. Hermans, K.G., van Alewijk, D.C., Veltman, J.A., van Weerden, W., van Kessel, A.G., Trapman, J. Genes Chromosomes Cancer (2004)
- Detection of gene amplification and deletion in high-grade gliomas using a genome DNA microarray (GenoSensor Array 300). Sasaki, T., Arai, H., Beppu, T., Ogasawara, K. Brain tumor pathology. (2003)
- Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion. Rosenstiel, P., Sina, C., End, C., Renner, M., Lyer, S., Till, A., Hellmig, S., Nikolaus, S., Fölsch, U.R., Helmke, B., Autschbach, F., Schirmacher, P., Kioschis, P., Hafner, M., Poustka, A., Mollenhauer, J., Schreiber, S. J. Immunol. (2007)
- Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors. Pang, J.C., Dong, Z., Zhang, R., Liu, Y., Zhou, L.F., Chan, B.W., Poon, W.S., Ng, H.K. Int. J. Cancer (2003)
- Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1). Haase, B., Humphray, S.J., Lyer, S., Renner, M., Poustka, A., Mollenhauer, J., Leeb, T. Gene (2006)
- Analysis of losses of heterozygosity of the candidate tumour suppressor gene DMBT1 in melanoma resection specimens. Deichmann, M., Mollenhauer, J., Helmke, B., Thome, M., Hartschuh, W., Poustka, A., Näher, H. Oncology (2002)
- Generation of a vector system facilitating cloning of DMBT1 variants and recombinant expression of functional full-length DMBT1. End, C., Lyer, S., Renner, M., Stahl, C., Ditzer, J., Holloschi, A., Kuhn, H.M., Flammann, H.T., Poustka, A., Hafner, M., Mollenhauer, J., Kioschis, P. Protein Expr. Purif. (2005)