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Chemical Compound Review

Buzz     1-azabicyclo[2.2.2]oct-8-yl 2-hydroxy-2,2...

Synonyms: Agent BZ, CHEMBL12980, SureCN59698, CHEMBL558910, Agent Buzz, ...
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Psychiatry related information on QUINUCLIDINYL BENZILATE


High impact information on QUINUCLIDINYL BENZILATE

  • ACh receptor distribution was determined by iontophoretic application of ACh and mapping of ACh sensitivity and by [3H]QNB (quinuclidinyl benzilate) binding and autoradiography [3H]QNB binds with > 90% specificity to a single, saturable, high-affinity (Kd = 11.1 pM at 21 degrees C) class of binding sites [11].
  • After 4 weeks of soman, three times a week, quinuclidinyl benzilate binding decreased to 67 to 80% of control in frontal and parietal cortex, caudate-putamen, lateral septum, hippocampal body, dentate gyrus, superior colliculus, nucleus of the fifth nerve, and central grey [12].
  • Initially, we examined the kinetics and specificity of the binding of radiolabeled quinuclidinyl benzilate ([3H]QNB) in slide-mounted, frozen tissue sections to determine that we were labeling the muscarinic cholinergic receptors as they had been described previously in biochemical pharmacological studies [13].
  • Muscarinic receptors purified from porcine atria and devoid of G protein underwent a 9-27-fold decrease in their apparent affinity for the antagonists quinuclidinyl benzilate, N-methylscopolamine, and scopolamine when treated with the thiol-selective reagent N-ethylmaleimide [14].
  • Binding of quinuclidinyl benzilate, a cholinergic receptor antagonist, indicated that down-regulation of external receptors was not an explanation for this effect [15].

Chemical compound and disease context of QUINUCLIDINYL BENZILATE






Associations of QUINUCLIDINYL BENZILATE with other chemical compounds




Analytical, diagnostic and therapeutic context of QUINUCLIDINYL BENZILATE


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  4. Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate. Bailey, J.L., Storey, B.T. Mol. Reprod. Dev. (1994) [Pubmed]
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