The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PDPN  -  podoplanin

Homo sapiens

Synonyms: AGGRUS, Aggrus, GP36, GP40, Glycoprotein 36, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PDPN


Psychiatry related information on PDPN


High impact information on PDPN


Chemical compound and disease context of PDPN

  • The mean width of the podocyte foot processes was inversely correlated with the protein levels of nephrin (r = -0.443, P < 0.05), whereas it was positively correlated with podoplanin mRNA levels (r = 0.468, P < 0.05) and proteinuria (r = 0.585, P = 0.001) [9].
  • METHODS: Lymphatic involvement was assessed by hematoxylin and eosin staining and podoplanin immunostaining on samples resected from 268 patients with submucosal colorectal cancer [10].
  • Quality of voice after treatment for T1A glottic squamous cell carcinoma was studied in two matched groups of males treated either with CO2 laser cordectomi (n = 18, mean age 65.2 years) or with full dose radiotherapy (n = 18, mean age 65.1 years) [11].

Biological context of PDPN

  • Expression of mouse Aggrus and its human homologue (also known as T1alpha-2/gp36) induced platelet aggregation without requiring plasma components [2].
  • These findings suggest a potential role of podoplanin in tumor progression, and they also identify the first commercially available antibody for the specific staining of a defined lymphatic marker in archival human tissue sections, thereby enabling more widespread studies of tumor lymphangiogenesis in human cancers [1].
  • Here we report that the periductal CT is populated by two distinct cell phenotypes; one expressing podoplanin, a protein otherwise found on lymph endothelia and on epithelia involved in fluid fluxes, and a second expressing a fibroblast marker [12].
  • In a recent genome-wide gene expression screening using cDNA microarrays, we found PDPN over-expressed in CIS compared to normal adult testis [3].
  • CONCLUSION: These data establish that in human osteoblast-like MG63 cells, Sp1 and Sp3 stimulate basal PDPN transcription in a concerted, yet independent manner, whereas Saos-2 cells lack sufficient nuclear Sp protein amounts for transcriptional activation [13].

Anatomical context of PDPN


Associations of PDPN with chemical compounds

  • We report the full cDNA sequence encoding the human homologue of murine PA2.26 (T1alpha-2, podoplanin), a small mucin-type transmembrane glycoprotein originally identified as a cell-surface antigen induced in keratinocytes during mouse skin carcinogenesis [14].
  • Concomitantly, treatment with the DNA methyltransferase inhibitor 5-azaCdR in combination with trichostatin A (TSA) downregulated podoplanin mRNA levels in MG63 cells, and region-specific in vitro methylation of the distal promoter suggested that DNA methylation rather enhanced than hindered PDPN transcription in both cell types [13].
  • Following reduction of T1A Cu(II), another ET process takes place between RSSR(-) and T1B copper(II) of domain 4 with a rate constant of 3.9 +/- 0 [16].
  • Real-time PCR was used to determine the mRNA levels of nephrin, podocin, and podoplanin in microdissected glomeruli [9].
  • EXPERIMENTAL DESIGN: Serial sections of 10 IBCs and 10 non-IBCs were immunostained for D2-40, LYVE-1, podoplanin, and PROX-1 [17].

Physical interactions of PDPN

  • Here, we found that human podoplanin directly interacts with ezrin (and moesin) in vitro and in vivo through a cluster of basic amino acids within its cytoplasmic tail, mainly through a juxtamembrane dipeptide RK [18].

Co-localisations of PDPN


Other interactions of PDPN


Analytical, diagnostic and therapeutic context of PDPN


  1. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Schacht, V., Dadras, S.S., Johnson, L.A., Jackson, D.G., Hong, Y.K., Detmar, M. Am. J. Pathol. (2005) [Pubmed]
  2. Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. Kato, Y., Fujita, N., Kunita, A., Sato, S., Kaneko, M., Osawa, M., Tsuruo, T. J. Biol. Chem. (2003) [Pubmed]
  3. Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours. Sonne, S.B., Herlihy, A.S., Hoei-Hansen, C.E., Nielsen, J.E., Almstrup, K., Skakkebaek, N.E., Marks, A., Leffers, H., Rajpert-De Meyts, E. Virchows Arch. (2006) [Pubmed]
  4. Reduction in 5-HT1A receptor density, 5-HT1A mRNA expression, and functional correlates for 5-HT1A receptors in genetically defined aggressive rats. Popova, N.K., Naumenko, V.S., Plyusnina, I.Z., Kulikov, A.V. J. Neurosci. Res. (2005) [Pubmed]
  5. Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. Nakamura, Y., Yasuoka, H., Tsujimoto, M., Kurozumi, K., Nakahara, M., Nakao, K., Kakudo, K. J. Clin. Pathol. (2006) [Pubmed]
  6. Monoclonal antibody SN10 which shows a highly selective reactivity with human B leukemia-lymphoma and is effectively internalized into cells. Takeuchi, T., Barcos, M.P., Seon, B.K. Cancer Res. (1991) [Pubmed]
  7. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Maruyama, K., Asai, J., Ii, M., Thorne, T., Losordo, D.W., D'Amore, P.A. Am. J. Pathol. (2007) [Pubmed]
  8. The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Kunita, A., Kashima, T.G., Morishita, Y., Fukayama, M., Kato, Y., Tsuruo, T., Fujita, N. Am. J. Pathol. (2007) [Pubmed]
  9. Expression of podocyte-associated molecules in acquired human kidney diseases. Koop, K., Eikmans, M., Baelde, H.J., Kawachi, H., De Heer, E., Paul, L.C., Bruijn, J.A. J. Am. Soc. Nephrol. (2003) [Pubmed]
  10. Lymphatic vessel density at the site of deepest penetration as a predictor of lymph node metastasis in submucosal colorectal cancer. Kaneko, I., Tanaka, S., Oka, S., Kawamura, T., Hiyama, T., Ito, M., Yoshihara, M., Shimamoto, F., Chayama, K. Dis. Colon Rectum (2007) [Pubmed]
  11. Voice evaluation before and after laser excision vs. radiotherapy of T1A glottic carcinoma. Rydell, R., Schalén, L., Fex, S., Elner, A. Acta Otolaryngol. (1995) [Pubmed]
  12. An interstitial network of podoplanin-expressing cells in the human endolymphatic duct. Hultgård-Ekwall, A.K., Mayerl, C., Rubin, K., Wick, G., Rask-Andersen, H. J. Assoc. Res. Otolaryngol. (2006) [Pubmed]
  13. Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells. Hantusch, B., Kalt, R., Krieger, S., Puri, C., Kerjaschki, D. BMC Mol. Biol. (2007) [Pubmed]
  14. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Martín-Villar, E., Scholl, F.G., Gamallo, C., Yurrita, M.M., Muñoz-Guerra, M., Cruces, J., Quintanilla, M. Int. J. Cancer (2005) [Pubmed]
  15. Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. Kaneko, M., Kato, Y., Kunita, A., Fujita, N., Tsuruo, T., Osawa, M. J. Biol. Chem. (2004) [Pubmed]
  16. Human ceruloplasmin. Intramolecular electron transfer kinetics and equilibration. Farver, O., Bendahl, L., Skov, L.K., Pecht, I. J. Biol. Chem. (1999) [Pubmed]
  17. Tumor lymphangiogenesis in inflammatory breast carcinoma: a histomorphometric study. Van der Auwera, I., Van den Eynden, G.G., Colpaert, C.G., Van Laere, S.J., van Dam, P., Van Marck, E.A., Dirix, L.Y., Vermeulen, P.B. Clin. Cancer Res. (2005) [Pubmed]
  18. Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition. Mart??n-Villar, E., Meg??as, D., Castel, S., Yurrita, M.M., Vilar??, S., Quintanilla, M. J. Cell. Sci. (2006) [Pubmed]
  19. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Breiteneder-Geleff, S., Soleiman, A., Kowalski, H., Horvat, R., Amann, G., Kriehuber, E., Diem, K., Weninger, W., Tschachler, E., Alitalo, K., Kerjaschki, D. Am. J. Pathol. (1999) [Pubmed]
  20. Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. Rubbia-Brandt, L., Terris, B., Giostra, E., Dousset, B., Morel, P., Pepper, M.S. Clin. Cancer Res. (2004) [Pubmed]
  21. CD9 expression on lymphatic vessels in head and neck mucosa. Erovic, B.M., Neuchrist, C., Kandutsch, S., Woegerbauer, M., Pammer, J. Mod. Pathol. (2003) [Pubmed]
  22. IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. Gröger, M., Loewe, R., Holnthoner, W., Embacher, R., Pillinger, M., Herron, G.S., Wolff, K., Petzelbauer, P. J. Immunol. (2004) [Pubmed]
  23. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Nibbs, R.J., Kriehuber, E., Ponath, P.D., Parent, D., Qin, S., Campbell, J.D., Henderson, A., Kerjaschki, D., Maurer, D., Graham, G.J., Rot, A. Am. J. Pathol. (2001) [Pubmed]
  24. Selective immunohistochemical staining of blood and lymphatic vessels reveals independent prognostic influence of blood and lymphatic vessel invasion in early-stage cervical cancer. Birner, P., Obermair, A., Schindl, M., Kowalski, H., Breitenecker, G., Oberhuber, G. Clin. Cancer Res. (2001) [Pubmed]
WikiGenes - Universities