Disease relevance of Mesocestoides

• To better understand the immune response and associated pathology in neurocysticercosis, a mouse model was developed by intracranial infection of BALB/c mice with Mesocestoides corti, a cestode organism related to T. solium [1].
• Mice infected with the parasite Mesocestoides corti undergo a polyclonal antibody response that results in a hypergammaglobulinemia restricted to the IgM and IgG1 isotypes [2].
• Detection of eosinophil differentiation factor and its relationship to eosinophilia in Mesocestoides corti-infected mice [3].
• The carbocyanine dyes DiI, DiA and DiO were microinjected into the cerebral ganglion of intact Mesocestoides corti tetrathyridia to determine the spatial organisation and connectivity patterns of the CNS [4].
• The effects of glucan and liposomized glucan, alone or co-administered with vitamin C, and empty liposomes on hepatic fibrosis in mice infected with Mesocestoides corti (M. vogae) tetrathyridia were studied [5].

High impact information on Mesocestoides

• Mice infected with the parasite Mesocestoides corti produce a vigorous antibody response that is restricted to the IgM and IgG1 heavy chain classes [6].
• Localization, specific activity, and molecular forms of acetylcholinesterase in developmental stages of the cestode Mesocestoides corti [7].
• The cestode parasite Mesocestoides corti is known to release at the larval stage several molecules including the heat shock proteins hsp70 and hsp60 [8].
• We investigated the suppressive effects of rolipram, RP 73401 (piclamilast), and other structurally diverse inhibitors of adenosine 3'5'-cyclic monophosphate (cAMP)-specific phosphodiesterase (PDE4) on anti-CD3-stimulated interleukin (IL)-4 and IL-5 generation by splenocytes from BALB/c mice infected with Mesocestoides (M) corti [9].
• We investigated the impact of co-administration of liposomized beta-glucan on the larvicidal effect of the anthelmintic praziquantel (PZQ) in the livers and peritoneal cavities in mice infected with Mesocestoides vogae (M. corti) [10].

Chemical compound and disease context of Mesocestoides

• Modulation of liver fibrosis and pathophysiological changes in mice infected with Mesocestoides corti (M. vogae) after administration of glucan and liposomized glucan in combination with vitamin C [5].

Biological context of Mesocestoides

• The current study was undertaken to gain further insight into the carbohydrate metabolism of the proliferating larvae of Mesocestoides corti by studying the effect of the metabolic inhibitors oxaloacetate and iodoacetate on the incorporation of label from NaH13CO3 into the excretory products lactate and succinate [11].

Associations of Mesocestoides with chemical compounds

• Effects of mebendazole and levamisole on tetrathyridia of Mesocestoides corti in the mouse [12].
• Mesocestoides corti (syn. M. vogae): modulation of larval motility by neuropeptides, serotonin and acetylcholine [13].
• Cortisone and the growth of populations of Mesocestoides tetrathyridia in mice [14].
• Tritiated thymidine ([3H]-TdR) and immunocytochemical tracing of cellular fate within the asexually dividing cestode Mesocestoides vogae (syn. M. corti) [15].
• Differential regulation of murine Mesocestoides corti infection by bacterial lipopolysaccharide and interferon-gamma [16].

Gene context of Mesocestoides

• Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of Mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors [9].
• An experimental, NADPH-diaphorase histochemical and immunocytochemical study of Mesocestoides vogae tetrathyridia [17].
• The serum from rats infected intraperitoneally (i.p.) and subcutaneously (s.c.) with the tetrathyridia of Mesocestoides corti was analysed for alpha-amylase, alkaline phosphatase, gamma-glutamyltransferase, glucose, corticosterone and total proteins [18].
• Fluorescent antibody studies of sera and intestinal extracts from mice subcutaneously vaccinated with tetrathyridia of Mesocestoides corti (Cestoda) [19].
• Mesocestoides corti: a LIM-homeobox gene upregulated during strobilar development [20].

References