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Gene Review

HDC  -  histidine decarboxylase

Homo sapiens

Synonyms: Histidine decarboxylase
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Disease relevance of HDC


High impact information on HDC


Chemical compound and disease context of HDC


Biological context of HDC


Anatomical context of HDC


Associations of HDC with chemical compounds


Physical interactions of HDC

  • We further showed that KLF4 inhibits HDC promoter activity by competing with Sp1 at the upstream GC box and also independently by binding the three downstream gastrin responsive elements [1].

Regulatory relationships of HDC


Other interactions of HDC

  • The lichen simplex samples had high expression of CRH-R1, but low HDC [2].
  • The mean values of histamine content and activities of HDC, HMT and histaminase of human nasal mucosa were 137.3 nmol/g wet weight, 26.3 fmol/min/mg protein, 26.4 pmol/min/mg protein and 0.5 pmol/min/mg protein, respectively [3].
  • HDC activity was found in WM35 and WM983 cell lines, while detectable HNMT activity was measured in WM983, M1 and HT168 lines [4].
  • Western blotting analysis was performed to verify the specificity of anti-DDC and anti-HDC antibodies [5].
  • Furthermore, we studied the effect of interleukin (IL)-4, which inhibits the HDC expression, on the expression of MCP-1 and CCR2 [23].

Analytical, diagnostic and therapeutic context of HDC


  1. Kruppel-like factor 4 (KLF4) represses histidine decarboxylase gene expression through an upstream Sp1 site and downstream gastrin responsive elements. Ai, W., Liu, Y., Langlois, M., Wang, T.C. J. Biol. Chem. (2004) [Pubmed]
  2. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria. Papadopoulou, N., Kalogeromitros, D., Staurianeas, N.G., Tiblalexi, D., Theoharides, T.C. J. Invest. Dermatol. (2005) [Pubmed]
  3. Histamine content, synthesis and degradation in human nasal mucosa. Abe, Y., Ogino, S., Irifune, M., Imamura, I., Fukui, H., Wada, H., Matsunaga, T. Clin. Exp. Allergy (1993) [Pubmed]
  4. Autonomous histamine metabolism in human melanoma cells. Darvas, Z., Sakurai, E., Schwelberger, H.G., Hegyesi, H., Rivera, E., Othsu, H., Watanabe, T., Pállinger, E., Falus, A. Melanoma Res. (2003) [Pubmed]
  5. Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis. Uccella, S., Cerutti, R., Vigetti, D., Furlan, D., Oldrini, R., Carnevali, I., Pelosi, G., La Rosa, S., Passi, A., Capella, C. J. Histochem. Cytochem. (2006) [Pubmed]
  6. Gastric endocrine cells: gene expression, processing, and targeting of active products. Dockray, G.J., Varro, A., Dimaline, R. Physiol. Rev. (1996) [Pubmed]
  7. Histamine is an intracellular messenger mediating platelet aggregation. Saxena, S.P., Brandes, L.J., Becker, A.B., Simons, K.J., LaBella, F.S., Gerrard, J.M. Science (1989) [Pubmed]
  8. Octreotide suppression test predicts beneficial outcome from antrectomy in a patient with gastric carcinoid tumor. Higham, A.D., Dimaline, R., Varro, A., Attwood, S., Armstrong, G., Dockray, G.J., Thompson, D.G. Gastroenterology (1998) [Pubmed]
  9. Helicobacter pylori infection: physiopathologic implication of N alpha-methyl histamine. Courillon-Mallet, A., Launay, J.M., Roucayrol, A.M., Callebert, J., Emond, J.P., Tabuteau, F., Cattan, D. Gastroenterology (1995) [Pubmed]
  10. Role of histamine produced by macrophages in mouse bone marrow. Takamatsu, S., Nakano, K. Methods and findings in experimental and clinical pharmacology. (1995) [Pubmed]
  11. Histamine metabolism in human gastric mucosa. Effect of pentagastrin stimulation. Lönroth, H., Rosengren, E., Olbe, L., Lundell, L. Gastroenterology (1990) [Pubmed]
  12. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Cianchi, F., Cortesini, C., Schiavone, N., Perna, F., Magnelli, L., Fanti, E., Bani, D., Messerini, L., Fabbroni, V., Perigli, G., Capaccioli, S., Masini, E. Clin. Cancer Res. (2005) [Pubmed]
  13. Alpha-fluoromethylhistidine in the treatment of idiopathic cold urticaria. Neittaanmäki, H., Fräki, J.E., Harvima, R.J., Förström, L. Arch. Dermatol. Res. (1989) [Pubmed]
  14. Pyridoxal phosphate-dependent histidine decarboxylase from Morganella AM-15. Snell, E.E., Guirard, B.M. Meth. Enzymol. (1986) [Pubmed]
  15. Structure of the L-histidine decarboxylase gene. Yatsunami, K., Ohtsu, H., Tsuchikawa, M., Higuchi, T., Ishibashi, K., Shida, A., Shima, Y., Nakagawa, S., Yamauchi, K., Yamamoto, M. J. Biol. Chem. (1994) [Pubmed]
  16. Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cells. Höcker, M., Rosenberg, I., Xavier, R., Henihan, R.J., Wiedenmann, B., Rosewicz, S., Podolsky, D.K., Wang, T.C. J. Biol. Chem. (1998) [Pubmed]
  17. Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. László, V., Rothe, G., Hegyesi, H., Szeberényi, J.B., Orsó, E., Schmitz, G., Falus, A. Inflamm. Res. (2001) [Pubmed]
  18. Modulation of histidine decarboxylase activity and cytokine synthesis in human leukemic cell lines: relationship with basophilic and/or megakaryocytic differentiation. Dy, M., Pacilio, M., Arnould, A., Machavoine, F., Mayeux, P., Hermine, O., Bodger, M., Schneider, E. Exp. Hematol. (1999) [Pubmed]
  19. Effects of histamine and interleukin-4 synthesized in arterial intima on phagocytosis by monocytes/macrophages in relation to atherosclerosis. Higuchi, S., Tanimoto, A., Arima, N., Xu, H., Murata, Y., Hamada, T., Makishima, K., Sasaguri, Y. FEBS Lett. (2001) [Pubmed]
  20. Yin yang 1 (YY1) represses histidine decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site. Ai, W., Liu, Y., Wang, T.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  21. Rat histidine decarboxylase promoter is regulated by gastrin through a protein kinase C pathway. Höcker, M., Zhang, Z., Fenstermacher, D.A., Tågerud, S., Chulak, M., Joseph, D., Wang, T.C. Am. J. Physiol. (1996) [Pubmed]
  22. Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. Sköldberg, F., Portela-Gomes, G.M., Grimelius, L., Nilsson, G., Perheentupa, J., Betterle, C., Husebye, E.S., Gustafsson, J., Rönnblom, A., Rorsman, F., Kämpe, O. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  23. Acute inflammatory reactions caused by histamine via monocytes/macrophages chronically participate in the initiation and progression of atherosclerosis. Kimura, S., Wang, K.Y., Tanimoto, A., Murata, Y., Nakashima, Y., Sasaguri, Y. Pathol. Int. (2004) [Pubmed]
  24. Upregulation of histidine decarboxylase mRNA expression in scleroderma skin. Ohtsuka, T., Ohtake, H., Matsuzaki, S., Ichimura, K., Ichikawa, A., Yamakage, A., Yamazaki, S. Arch. Dermatol. Res. (2001) [Pubmed]
  25. Generation and subcellular distribution of histamine in human blood monocytes and monocyte subsets. Zwadlo-Klarwasser, G., Vogts, M., Hamann, W., Belke, K., Baron, J., Schmutzler, W. Inflamm. Res. (1998) [Pubmed]
  26. Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells. Tippens, A.S., Gruetter, C.A. Inflamm. Res. (2004) [Pubmed]
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