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MeSH Review

Heat Stroke

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Disease relevance of Heat Stroke


High impact information on Heat Stroke


Chemical compound and disease context of Heat Stroke

  • Hypothalamic dopamine release and local cerebral blood flow during onset of heatstroke in rats [4].
  • MEASUREMENTS AND MAIN RESULTS: After onset of heatstroke, HRJVF significantly decreased the glutamate release [9].
  • CONCLUSIONS: We successfully demonstrated that estrogen replacement may improve survival during heatstroke by ameliorating inflammatory responses and cardiovascular dysfunction [7].
  • CONCLUSION: We successfully demonstrated that HBO and, to some extent, hyperbaric air, normobaric hyperoxia, or HBO 8% was found beneficial in resuscitating rats with experimental heatstroke [10].
  • OBJECTIVE: To investigate the potential role of taurine as a hypothermic modulator during heatstroke [11].

Biological context of Heat Stroke


Anatomical context of Heat Stroke


Gene context of Heat Stroke


Analytical, diagnostic and therapeutic context of Heat Stroke


  1. Disseminated intravascular coagulation in heat stroke. Response to heparin therapy. Perchick, J.S., Winkelstein, A., Shadduck, R.K. JAMA (1975) [Pubmed]
  2. Possible central role of nitric oxide in conditions clinically similar to cerebral malaria. Clark, I.A., Rockett, K.A., Cowden, W.B. Lancet (1992) [Pubmed]
  3. The metabolic and respiratory alterations of heat stroke. Sprung, C.L., Portocarrero, C.J., Fernaine, A.V., Weinberg, P.F. Arch. Intern. Med. (1980) [Pubmed]
  4. Hypothalamic dopamine release and local cerebral blood flow during onset of heatstroke in rats. Kao, T.Y., Chio, C.C., Lin, M.T. Stroke (1994) [Pubmed]
  5. Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. Ward, A., Chaffman, M.O., Sorkin, E.M. Drugs (1986) [Pubmed]
  6. Treatment of heat stroke with dantrolene. Lydiatt, J.S., Hill, G.E. JAMA (1981) [Pubmed]
  7. Resuscitation from experimental heatstroke by estrogen therapy. Chen, S.H., Chang, F.M., Niu, K.C., Lin, M.Y., Lin, M.T. Crit. Care Med. (2006) [Pubmed]
  8. Resuscitation from experimental heatstroke by transplantation of human umbilical cord blood cells. Chen, S.H., Chang, F.M., Tsai, Y.C., Huang, K.F., Lin, M.T. Crit. Care Med. (2005) [Pubmed]
  9. Hypothermic retrograde jugular vein flush in heatstroke rats provides brain protection by maintaining cerebral blood flow but not by hemodilution. Wen, Y.S., Huang, M.S., Lin, M.T., Lee, C.H. Crit. Care Med. (2004) [Pubmed]
  10. Resuscitation from experimental heatstroke by hyperbaric oxygen therapy. Tsai, H.M., Gao, C.J., Li, W.X., Lin, M.T., Niu, K.C. Crit. Care Med. (2005) [Pubmed]
  11. Alteration of taurine homeostasis in acute heatstroke. Bouchama, A., el-Yazigi, A., Yusuf, A., al-Sedairy, S. Crit. Care Med. (1993) [Pubmed]
  12. Ipsapirone and ketanserin protects against circulatory shock, intracranial hypertension, and cerebral ischemia during heatstroke. Chang, C.P., Chen, S.H., Lin, M.T. Shock (2005) [Pubmed]
  13. Peripheral vascular responses to hyperthermia in the rat. Kregel, K.C., Wall, P.T., Gisolfi, C.V. J. Appl. Physiol. (1988) [Pubmed]
  14. Plasma-cortisol levels in experimental heatstroke in dogs. Assia, E., Epstein, Y., Magazanik, A., Shapiro, Y., Sohar, E. International journal of biometeorology. (1989) [Pubmed]
  15. Sheng mai san, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat. Lee, I.Y., Lee, C.C., Chang, C.K., Chien, C.H., Lin, M.T. Clin. Exp. Pharmacol. Physiol. (2005) [Pubmed]
  16. Blood lactate threshold and type II fibre predominance in patients with exertional heatstroke. Hsu, Y.D., Lee, W.H., Chang, M.K., Shieh, S.D., Tsao, W.L. J. Neurol. Neurosurg. Psychiatr. (1997) [Pubmed]
  17. The protective effect of hypervolemic hemodilution in experimental heatstroke. Chang, C.K., Chien, C.H., Chou, H.L., Lin, M.T. Shock (2001) [Pubmed]
  18. Magnolol protects against cerebral ischaemic injury of rat heatstroke. Chang, C.P., Hsu, Y.C., Lin, M.T. Clin. Exp. Pharmacol. Physiol. (2003) [Pubmed]
  19. Hyperpyrexia in the emergency department. McGugan, E.A. Emergency medicine (Fremantle, W.A.) (2001) [Pubmed]
  20. Protective and anti-fatigue effects of aspirin against heatstroke in rats. Chen, A.H., Song, X.D., Luo, B.D., Zou, F. Sheng li xue bao [Acta physiologica Sinica]. (2005) [Pubmed]
  21. Role of circulating cytokines and chemokines in exertional heatstroke. Lu, K.C., Wang, J.Y., Lin, S.H., Chu, P., Lin, Y.F. Crit. Care Med. (2004) [Pubmed]
  22. Elevated pyrogenic cytokines in heatstroke. Bouchama, A., al-Sedairy, S., Siddiqui, S., Shail, E., Rezeig, M. Chest (1993) [Pubmed]
  23. Inhibition of different types of nitric oxide synthase: effect on thermoregulation in the rat exposed to high ambient temperature. Canini, F., Buguet, A., Bourdon, L. Neurosci. Lett. (2001) [Pubmed]
  24. Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. Bouchama, A., Parhar, R.S., el-Yazigi, A., Sheth, K., al-Sedairy, S. J. Appl. Physiol. (1991) [Pubmed]
  25. Oral glutamine enhances heat shock protein expression and improves survival following hyperthermia. Singleton, K.D., Wischmeyer, P.E. Shock (2006) [Pubmed]
  26. Is dantrolene effective in heat stroke patients? Channa, A.B., Seraj, M.A., Saddique, A.A., Kadiwal, G.H., Shaikh, M.H., Samarkandi, A.H. Crit. Care Med. (1990) [Pubmed]
  27. Differential effects of in vitro and in vivo hyperthermia on the production of interleukin-10. Bouchama, A., Hammami, M.M., Al Shail, E., De Vol, E. Intensive care medicine. (2000) [Pubmed]
  28. Cocaine and body temperature: effect of exercise at high ambient temperature. Lomax, P., Daniel, K.A. Pharmacology (1993) [Pubmed]
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