Disease relevance of Blindness, Cortical

• We describe severe central nervous system (CNS) toxicity, manifested by confusion, cortical blindness, quadriplegia, seizures, and coma, associated with cyclosporine treatment in three patients undergoing liver transplantation [1].
• The clinical presentation of cyclosporine neurotoxicity was characterized by tremulousness and restlessness in all patients and was associated with acute confusional state and psychosis in 20 patients, seizures in eight, speech apraxia or action myoclonus speech in three, and cortical blindness in two [2].
• The patient had prenatal growth failure, borderline microcephaly, dilated lateral horns of the cerebral ventricles, transient cortical blindness, myopia, muscle hypotonia, and dilatation of the left renal collecting system [3].
• Seizures and cortical blindness after meglumine (hypaque) administration: a variant of autonomic dysreflexia [4].
• The cases of three children, 16, 12, and 12 years of age, who suffered sudden confusional state and cortical blindness lasting 12 to 30 minutes while under treatment with high-dose methotrexate, cyclophosphamide, and dactinomycin for a lower limb osteosarcoma are reported [5].

Psychiatry related information on Blindness, Cortical

• Cyclosporine has been associated with various neurological side-effects including postural tremor, seizures, headaches, encephalopathy, cortical blindness, and visual hallucinations [6].
• One serious adverse event occurred in the iodixanol group where a patient experienced transient cortical blindness and transitory global amnesia, but the patient recovered completely the day after the examination [7].
• Interferon (IFN) related neurotoxicity includes somnolence and confusion, fatigue, lethargy, psychiatric symptoms, conceptual disorganization, neurological deficits, cortical blindness, coma and, rarely, death [8].

High impact information on Blindness, Cortical

• The most consistent regional alterations were found in the parieto-occipital cortex (9 cases), the frontier between vertebral and carotid arterial territories, followed by the frontomesial junction (5 cases), the striatum (3 cases with dystonia), thalamus (2 cases), and visual cortex (2 cases with cortical blindness) [9].
• The diffusion weighted MR findings at the acute phase of a neurological event in MELAS are described and the pathophysiology of stroke-like lesion in the light of diffusion changes is discussed.Brain MRI was performed 2 days after the sudden onset of cortical blindness in a 25 year old patient with MELAS [10].
• Cortical blindness and seizures following cisplatin treatment: both of epileptic origin [11]?
• On day +19 she developed cortical blindness, headache and convulsions which were associated with white matter changes on MRI scanning of the head and elevated cyclosporin A levels [12].
• The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness [13]?

Chemical compound and disease context of Blindness, Cortical

• We report the case of a C2 quadriplegic patient who developed clinical features of AD along with cortical blindness and seizures after administration of meglumine (Hypaque) for diagnostic cystogram [4].
• Transient cortical blindness in an infant exposed to methamphetamine [14].
• Cortical blindness in acute carbon monoxide poisoning [15].
• Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man [16].
• Transient cortical blindness has not previously been attributed to vincristine sulfate therapy, but must be considered as a possible complication of treatment with this agent [17].

Biological context of Blindness, Cortical

• Visual evoked potentials (VEPs) and visual evoked spectrum array (VESA) to flashes and pattern-reversal were correlated with regional cerebral blood flow (rCBF) or local cerebral glucose metabolism in 4 hemianopsic patients and one subject with cortical blindness [18].

Anatomical context of Blindness, Cortical

• We report a bone marrow transplant patient who developed a reversible episode of cortical blindness, a rare complication of cyclosporine therapy [19].
• We describe a 13-year-old male patient with macrocephaly, mild developmental delay, increased signal intensity in the basal ganglia bilaterally, partial cortical blindness, and retinitis pigmentosa [20].
• D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle [21].
• The importance of obtaining a blood or cerebrospinal fluid lactate in all infants with unexplained seizures, cortical blindness or apnoea is emphasized [22].
• The other 42 children with strabismus all had ophthalmological disorders (i.e. ROP, optic nerve atrophy, cortical blindness) explaining early disruption of binocular visual development [23].

Gene context of Blindness, Cortical

• The probands have the following features in common; normal early development, short stature, deterioration of intellectual ability, convulsions, cardiac conduction defect, sensorineural hearing loss, cortical blindness, and hemiparesis [24].
• Cells in the CSF from a patient with SLE who developed transient cortical blindness with denial of visual loss (Anton's syndrome) were subjected to detailed morphologic classification [25].
• A case of cortical blindness resulting from a dense ischemic lesion of both calcarine cortices (as seen on CAT Scan) was studied up till the seventh month after the initial stroke [26].
• Injuries to the visual cortex in adult humans can produce blindness, referred to as "cortical blindness". In children some degree of visual recovery has been noted in comparable injuries and for that reason the term "cortical visual impairment" has been suggested as a more appropriate diagnosis in children [27].
• Reversible cortical blindness as a complication of rheumatoid arthritis of the cervical spine [28].

Analytical, diagnostic and therapeutic context of Blindness, Cortical

• We present a patient with cortical blindness secondary to cyclosporine after orthotopic heart transplantation [29].
• Reversible cyclosporine-induced cortical blindness in allogeneic bone marrow transplant recipients [30].
• PATIENT: A patient with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) who had cortical blindness and profound sensorineural hearing loss was evaluated and rehabilitated with cochlear implantation [31].

References