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MeSH Review

Blindness, Cortical

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Disease relevance of Blindness, Cortical


Psychiatry related information on Blindness, Cortical


High impact information on Blindness, Cortical

  • The most consistent regional alterations were found in the parieto-occipital cortex (9 cases), the frontier between vertebral and carotid arterial territories, followed by the frontomesial junction (5 cases), the striatum (3 cases with dystonia), thalamus (2 cases), and visual cortex (2 cases with cortical blindness) [9].
  • The diffusion weighted MR findings at the acute phase of a neurological event in MELAS are described and the pathophysiology of stroke-like lesion in the light of diffusion changes is discussed.Brain MRI was performed 2 days after the sudden onset of cortical blindness in a 25 year old patient with MELAS [10].
  • Cortical blindness and seizures following cisplatin treatment: both of epileptic origin [11]?
  • On day +19 she developed cortical blindness, headache and convulsions which were associated with white matter changes on MRI scanning of the head and elevated cyclosporin A levels [12].
  • The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness [13]?

Chemical compound and disease context of Blindness, Cortical


Biological context of Blindness, Cortical

  • Visual evoked potentials (VEPs) and visual evoked spectrum array (VESA) to flashes and pattern-reversal were correlated with regional cerebral blood flow (rCBF) or local cerebral glucose metabolism in 4 hemianopsic patients and one subject with cortical blindness [18].

Anatomical context of Blindness, Cortical


Gene context of Blindness, Cortical

  • The probands have the following features in common; normal early development, short stature, deterioration of intellectual ability, convulsions, cardiac conduction defect, sensorineural hearing loss, cortical blindness, and hemiparesis [24].
  • Cells in the CSF from a patient with SLE who developed transient cortical blindness with denial of visual loss (Anton's syndrome) were subjected to detailed morphologic classification [25].
  • A case of cortical blindness resulting from a dense ischemic lesion of both calcarine cortices (as seen on CAT Scan) was studied up till the seventh month after the initial stroke [26].
  • Injuries to the visual cortex in adult humans can produce blindness, referred to as "cortical blindness". In children some degree of visual recovery has been noted in comparable injuries and for that reason the term "cortical visual impairment" has been suggested as a more appropriate diagnosis in children [27].
  • Reversible cortical blindness as a complication of rheumatoid arthritis of the cervical spine [28].

Analytical, diagnostic and therapeutic context of Blindness, Cortical


  1. Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. de Groen, P.C., Aksamit, A.J., Rakela, J., Forbes, G.S., Krom, R.A. N. Engl. J. Med. (1987) [Pubmed]
  2. Neurotoxicity in liver transplant recipients with cyclosporine immunosuppression. Wijdicks, E.F., Wiesner, R.H., Krom, R.A. Neurology (1995) [Pubmed]
  3. Molecular cytogenetic studies in three patients with partial trisomy 2p, including CGH from paraffin-embedded tissue. Aviram-Goldring, A., Fritz, B., Bartsch, C., Steuber, E., Daniely, M., Lev, D., Chaki, R., Barkai, G., Frydman, M., Rehder, H. Am. J. Med. Genet. (2000) [Pubmed]
  4. Seizures and cortical blindness after meglumine (hypaque) administration: a variant of autonomic dysreflexia. Sahota, P.K., Johnson, L.N., Arora, R., Hillard, A. J. Auton. Nerv. Syst. (1994) [Pubmed]
  5. Transient posterior encephalopathy induced by chemotherapy in children. Sánchez-Carpintero, R., Narbona, J., López de Mesa, R., Arbizu, J., Sierrasesúmaga, L. Pediatric neurology. (2001) [Pubmed]
  6. Parkinsonism during cyclosporine treatment. Wasserstein, P.H., Honig, L.S. Bone Marrow Transplant. (1996) [Pubmed]
  7. Iodixanol and ioxaglate in cardioangiography: a double-blind randomized phase III study. Andersen, P.E., Bolstad, B., Berg, K.J., Justesen, P., Thayssen, P., Kloster, Y.F. Clinical radiology. (1993) [Pubmed]
  8. Neurotoxicity of interferon-alpha. Merimsky, O., Chaitchik, S. Anticancer Drugs (1992) [Pubmed]
  9. Brain glucose metabolism in postanoxic syndrome. Positron emission tomographic study. DeVolder, A.G., Goffinet, A.M., Bol, A., Michel, C., de Barsy, T., Laterre, C. Arch. Neurol. (1990) [Pubmed]
  10. Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS? Oppenheim, C., Galanaud, D., Samson, Y., Sahel, M., Dormont, D., Wechsler, B., Marsault, C. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  11. Cortical blindness and seizures following cisplatin treatment: both of epileptic origin? van Gelder, T., Geurs, P., Kho, G.S., Dippel, D.W., Vecht, C.J., Splinter, T.A. Eur. J. Cancer (1993) [Pubmed]
  12. Reversible cortical blindness and convulsions with cyclosporin A toxicity in a patient undergoing allogeneic peripheral stem cell transplantation. Madan, B., Schey, S.A. Bone Marrow Transplant. (1997) [Pubmed]
  13. The wounding of Alexander the Great in Cyropolis (329 BC): the first reported case of the syndrome of transient cortical blindness? Lascaratos, J. Survey of ophthalmology. (1997) [Pubmed]
  14. Transient cortical blindness in an infant exposed to methamphetamine. Gospe, S.M. Annals of emergency medicine. (1995) [Pubmed]
  15. Cortical blindness in acute carbon monoxide poisoning. Katafuchi, Y., Nishimi, T., Yamaguchi, Y., Matsuishi, T., Kimura, Y., Otaki, E., Yamashita, Y. Brain Dev. (1985) [Pubmed]
  16. Seizures and transient cortical blindness associated with cis-platinum (II) diamminedichloride (PDD) therapy in a thirty-year-old man. Berman, I.J., Mann, M.P. Cancer (1980) [Pubmed]
  17. Transient cortical blindness secondary to vincristine therapy in childhood malignancies. Byrd, R.L., Rohrbaugh, T.M., Raney, R.B., Norris, D.G. Cancer (1981) [Pubmed]
  18. Visual evoked potentials and positron emission tomographic mapping of regional cerebral blood flow and cerebral metabolism: can the neuronal potential generators be visualized? Celesia, G.G., Polcyn, R.D., Holden, J.E., Nickles, R.J., Gatley, J.S., Koeppe, R.A. Electroencephalography and clinical neurophysiology. (1982) [Pubmed]
  19. Cortical blindness: a rare complication of cyclosporine therapy. Ghalie, R., Fitzsimmons, W.E., Bennett, D., Kaizer, H. Bone Marrow Transplant. (1990) [Pubmed]
  20. Mild elevation of N-acetylaspartic acid and macrocephaly: diagnostic problem. Surendran, S., Bamforth, F.J., Chan, A., Tyring, S.K., Goodman, S.I., Matalon, R. J. Child Neurol. (2003) [Pubmed]
  21. D-2-hydroxyglutaric aciduria: hypotonia, cortical blindness, seizures, cardiomyopathy, and cylindrical spirals in skeletal muscle. Baker, N.S., Sarnat, H.B., Jack, R.M., Patterson, K., Shaw, D.W., Herndon, S.P. J. Child Neurol. (1997) [Pubmed]
  22. Infant onset subacute necrotizing encephalomyelopathy (Leigh's disease). Morris, S.A., Harbord, M.G. Journal of paediatrics and child health. (1993) [Pubmed]
  23. Infantile esotropia in very low birth weight (VLBW) children. Pott, J.W., Sprunger, D.T., Helveston, E.M. Strabismus (1999) [Pubmed]
  24. Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) and diabetes mellitus: molecular genetic analysis and family study. Onishi, H., Inoue, K., Osaka, H., Kimura, S., Nagatomo, H., Hanihara, T., Kawamoto, S., Okuda, K., Yamada, Y., Kosaka, K. J. Neurol. Sci. (1993) [Pubmed]
  25. Cerebrospinal fluid cytomorphology in systemic lupus erythematosus with Anton's syndrome. Jaeckle, K.A. Acta Cytol. (1982) [Pubmed]
  26. Residual visual capacities in a case of cortical blindness. Perenin, M.T., Ruel, J., Hécaen, H. Cortex; a journal devoted to the study of the nervous system and behavior. (1980) [Pubmed]
  27. Visual function in the brain-damaged child. Hoyt, C.S. Eye (London, England) (2003) [Pubmed]
  28. Reversible cortical blindness as a complication of rheumatoid arthritis of the cervical spine. Snelling, J.P., Pickard, J., Wood, S.K., Prouse, P.J. Br. J. Rheumatol. (1990) [Pubmed]
  29. Cortical blindness secondary to cyclosporine after orthotopic heart transplantation: a case report and review of the literature. Drachman, B.M., DeNofrio, D., Acker, M.A., Galetta, S., Loh, E. J. Heart Lung Transplant. (1996) [Pubmed]
  30. Reversible cyclosporine-induced cortical blindness in allogeneic bone marrow transplant recipients. Memon, M., deMagalhaes-Silverman, M., Bloom, E.J., Lister, J., Myers, D.J., Pincus, S.M., Rybka, W.B., Ball, E.D. Bone Marrow Transplant. (1995) [Pubmed]
  31. Successful cochlear implantation in a patient with MELAS syndrome. Rosenthal, E.L., Kileny, P.R., Boerst, A., Telian, S.A. The American journal of otology. (1999) [Pubmed]
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