The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Etantiolo     ethanethiol

Synonyms: Ethaanthiol, Ethanethiol, Thioethanol, Aethanethiol, Ethylmerkaptan, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ethanethiol


High impact information on ethanethiol

  • In addition, three of the four variants were shown to be phosphorylated by alkaline phosphatase digestion, microphosphate analysis, and ethanethiol derivatization coupled with amino acid sequence analysis; these variants were shown to have 1, 2, or 3 phosphate groups per peptide chain, which corresponded to their increasing acidic nature [6].
  • Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases [7].
  • Characterization of serine and threonine phosphorylation sites in beta-elimination/ethanethiol addition-modified proteins by electrospray tandem mass spectrometry and database searching [8].
  • We have determined the exact phosphorylation sites in both PHF-tau and fetal rat tau by ion-spray mass spectrometry and sequencing of ethanethiol-modified peptides [9].
  • All animals fed 3-ethylthiopropionate expired a volatile sulfur compound that was identified as ethanethiol by gas chromatography using both a general flame ionization detector and a sulfur specific flame photometric detector [10].

Chemical compound and disease context of ethanethiol

  • Unlike reaction of ethanethiol with 9 and 10, reaction with N-acetylecysteine or glutathione results in epoxide opening followed by dehydration leading to the formation of estradiol-4-thioethers [1].

Biological context of ethanethiol


Anatomical context of ethanethiol


Associations of ethanethiol with other chemical compounds


Gene context of ethanethiol

  • Reduction of the methyldehydroalanine (Mdha) residue of MCYST-LR with ethanethiol totally abolished the covalent binding of the toxin to PP1, but retained its inhibitory toxicity on PP1 [22].
  • In order to generalize this approach, a N(alpha)-2-phenyl ethanethiol scaffold has been developed to promote S to N acyl transfer in a manner analogous to native chemical ligation with N-terminal cysteine residues [23].
  • The fast reaction, which represents a binding reaction of ethanethiol to cytochrome c oxidase, has a k1 of 33 M-1 . s-1 and a dissociation constant Kd of 3.9 mM [24].
  • 4. Ethanethiol induces fast spectral changes in the absorption spectrum of cytochrome c, which are followed by a very slow reduction of the heme [24].
  • Moreover, an increase in pH from 3.6 to 5.1 exponentially increased the reaction rate of ethanethiol (e.g., k2 = 25-4200 L/mol/sec from pH 3.6 to 5.1) and significantly increased the reaction rate of DMDS if increased to pH 9 (k3 = 1.4 x 10(6) L2/mol2/sec) [25].

Analytical, diagnostic and therapeutic context of ethanethiol

  • The amino acid sequence of the purified active fraction was obtained by Edman degradation after treatment with alkaline ethanethiol [26].
  • These studies indicate that the N(alpha)-2-phenyl ethanethiol scaffold is a good candidate for the development of a ligation chemistry for the formation of Xaa-Gly peptides and other unhindered amides [23].
  • The calculated adsorption quantity of ethanethiol in MFI is close agreement with the experimental data by means of IR spectroscopy and thermogravimetry [27].
  • The self-assembly of ethanethiol (C(2)) and 1-octanethiol (C(8)) on Ag-Au(111) alloy films was studied by X-ray photoelectron spectroscopy (XPS), cyclic voltammetry (CV), and scanning tunneling microscopy (STM), to illuminate how the monolayer structures and chemisorption-induced substrate defect structures depend on the alloy composition [28].


  1. Reaction of thiol nucleophiles with 1,2-epoxy- and 4,5-epoxy-estrene-3-one-17 beta-ols. Ghaffari, M.A., Abul-Hajj, Y.J. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
  2. Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia. Grdina, D.J., Nagy, B., Hill, C.K., Sigdestad, C.P. Radiat. Res. (1989) [Pubmed]
  3. Volatile organic sulfur compounds in anaerobic sludge and sediments: biodegradation and toxicity. van Leerdam, R.C., de Bok, F.A., Lomans, B.P., Stams, A.J., Lens, P.N., Janssen, A.J. Environ. Toxicol. Chem. (2006) [Pubmed]
  4. Mercaptoethane sulphonate in cystinic calculosis therapy. Di Silverio, F., Gallucci, M., Ricciuti, G.P., Alpi, G., Fini, D., Cassanelli, A., Molinari, C. Contributions to nephrology. (1987) [Pubmed]
  5. Comparative value of different dialysis membranes, including a carbon coated membrane for removal of noxious substances in hepatic coma. Mardini, H.A., Hoenich, N., Bartlett, K., Record, C.O. The International journal of artificial organs. (1979) [Pubmed]
  6. The isolation and chemical characterization of phosphorylated enkephalin-containing peptides from bovine adrenal medulla. Watkinson, A., Young, J., Varro, A., Dockray, G.J. J. Biol. Chem. (1989) [Pubmed]
  7. Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. Jenner, A., England, T.G., Aruoma, O.I., Halliwell, B. Biochem. J. (1998) [Pubmed]
  8. Characterization of serine and threonine phosphorylation sites in beta-elimination/ethanethiol addition-modified proteins by electrospray tandem mass spectrometry and database searching. Jaffe, H., Veeranna, n.u.l.l., Pant, H.C. Biochemistry (1998) [Pubmed]
  9. Hyperphosphorylation of tau in PHF. Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Watanabe, A., Titani, K., Ihara, Y. Neurobiol. Aging (1995) [Pubmed]
  10. Role of 3-ethylthiopropionate in ethionine metabolism and toxicity in rats. Steele, R.D. J. Nutr. (1982) [Pubmed]
  11. Cysteine: a potential source of error in amino acid analysis of mercaptoethane sulfonic or hydrochloric acid hydrolysates of proteins and peptides. Gardner, M.L. Anal. Biochem. (1984) [Pubmed]
  12. 2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Schwartz, J.L., Giovanazzi, S.M., Karrison, T., Jones, C., Grdina, D.J. Radiat. Res. (1988) [Pubmed]
  13. The kinetics of catalytic incineration of C2H5SH and (CH3)2S2 over a Pt/Al2O3 catalyst. Chu, H., Lee, W.T., Chiou, Y.Y., Tseng, T.K. Environmental technology. (2001) [Pubmed]
  14. Inhibition of mitochondrial electron transfer in rats by ethanethiol and methanethiol. Vahlkamp, T., Meijer, A.J., Wilms, J., Chamuleau, R.A. Clin. Sci. (1979) [Pubmed]
  15. Reconstitution of the D-glucose transporter of bovine thymocyte plasma membrane: partial purification of transport activity by chromatography on agarose lentil lectin and agarose ethanethiol. Schraw, W.P., Regen, D.M. Arch. Biochem. Biophys. (1983) [Pubmed]
  16. A selective precipitation purification procedure for multiple phosphoseryl-containing peptides and methods for their identification. Reynolds, E.C., Riley, P.F., Adamson, N.J. Anal. Biochem. (1994) [Pubmed]
  17. An improved method for the determination of gamma-carboxyglutamic acid in proteins, bone, and urine. Kuwada, M., Katayama, K. Anal. Biochem. (1983) [Pubmed]
  18. In vitro inhibition of rat liver cholest-5en-3 beta-ol (cholesterol) biosynthesis by non-mercurial sulfhydryl reagents. Abernethy, D., Hignite, C., Azarnoff, D.L. Steroids (1976) [Pubmed]
  19. HPLC-based method using sample pre-column clean-up for the determination of methanethiol and ethanethiol in parenteral amino acid solutions. do Nascimento, P.C., Bohrer, D., Rohlfes, A.L., de Carvalho, L.M., Ramirez, A. Fresenius' journal of analytical chemistry. (2001) [Pubmed]
  20. N-trichloroethoxycarbonyl-glucosamine derivatives as glycosyl donors. Dullenkopf, W., Castro-Palomino, J.C., Manzoni, L., Schmidt, R.R. Carbohydr. Res. (1996) [Pubmed]
  21. Surface-enhanced Raman spectra of VX and its hydrolysis products. Farquharson, S., Gift, A., Maksymiuk, P., Inscore, F. Applied spectroscopy. (2005) [Pubmed]
  22. Monitoring of microcystin-protein phosphatase adduct formation with immunochemical methods. Liu, B.H., Yu, F.Y., Huang, X., Chu, F.S. Toxicon (2000) [Pubmed]
  23. A new scaffold for amide ligation. Marinzi, C., Bark, S.J., Offer, J., Dawson, P.E. Bioorg. Med. Chem. (2001) [Pubmed]
  24. Reactions of mercaptans with cytochrome c oxidase and cytochrome c. Wilms, J., Lub, J., Wever, R. Biochim. Biophys. Acta (1980) [Pubmed]
  25. Effect of pH and temperature on the kinetics of odor oxidation using chlorine dioxide. Kastner, J.R., Das, K.C., Hu, C., McClendon, R. Journal of the Air & Waste Management Association (1995) (2003) [Pubmed]
  26. Purification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans. Mota-Meira, M., Lacroix, C., LaPointe, G., Lavoie, M.C. FEBS Lett. (1997) [Pubmed]
  27. Computer simulation of the adsorption of ethanethiol in silicalite of MFI and MOR. Ju, S.G., Zeng, Y.P., Yao, H.Q. The Journal of chemical physics. (2004) [Pubmed]
  28. Self-assembly of alkanethiol monolayers on ag-au(111) alloy surfaces. Kawasaki, M., Iino, M. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
WikiGenes - Universities