The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1Q3LER     N-[(4- chlorophenyl)carbamoyl]-2,6- difluoro...

Synonyms: AR-1K8459, DC 702, DC 703, AC1L33EN, 64082-71-9, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DC 703

  • Saturnine gout among Roman aristocrats. Did lead poisoning contribute to the fall of the Empire [1]?
  • Cases of massive obesity were identified in stone age carvings and have been described frequently since the time of Galen and the Roman Empire. More specific types of obesity began to be identified in the 19th century [2].
  • The pandemic ravaged the entire extent of the Roman Empire, from its eastern frontiers in Iraq to its western frontiers on the Rhine River and Gaul, modern France, and western Germany. The disease is identified most often as smallpox, but it may have been anthrax [3].
  • Regina Salomea Rusiecki (later Pilsztynowa) was a young, poorly educated Polish Catholic woman in the 18th century who became well known in Eastern Europe and the Ottoman Empire because of her skill in the treatment of cataracts and some other medical problems [4].
  • Classic pages in obstetrics and gynecology. Operation in cases of complete prolapse. Archibald Donald. Journal of Obstetrics and Gynaecology of the British Empire, vol. 13, pp. 195-196, 1908 [5].

Psychiatry related information on DC 703


High impact information on DC 703

  • From the dozen facilities created in the Russian Empire, it grew during the Soviet period to include over 100 facilities engaged in public health activities as well as BW-related work [8].
  • The reconstructed house of ophthalmologist, Sextus Ajacius Launus, and its contents provides a fascinating glimpse of ophthalmology as practiced nearly 17 centuries ago in the Roman Empire [9].
  • RESULTS: Whereas a total of 228 cases were diagnosed with pneumonic plague in areas under direct control of the Japanese Empire, 4781 cases were also recorded in surrounding areas [10].
  • Epidemiology of a primary pneumonic plague in Kantoshu, Manchuria, from 1910 to 1911: statistical analysis of individual records collected by the Japanese Empire [10].
  • The contents of each antioxidant in Empire apples was quantified and their contributions to total antioxidant activity of apples were determined using assay for inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced superoxide radical generation in cell culture model and expressed in vitamin C equivalent antioxidant capacity (VCEAC) [11].

Biological context of DC 703

  • The survey was developed by the CF committee of the Genetics Network of the Empire State, Puerto Rico, and the U.S. Virgin Islands (GENES) to gauge changes in trends following the April, 1997, NIH Consensus Statement recommending the offering of CF carrier screening to all pregnant patients [12].
  • Then, the essay analyzes the changes in family structures and inheritance patterns and discusses the impact of political events such as the end of overseas migration, the dissolution of the Austro-Hungarian Empire, the autarchic policies of the "successor states" and the failure of land reform on peasants' lives [13].
  • This paper covers major events of the early history of chlorophyll research in the Russian Empire and the Soviet Union from 1771 until 1952, when the modern period of studies on photosynthesis began in full swing [14].
  • Pediatric dermatology in antiquity Part II. Roman Empire [15].

Anatomical context of DC 703

  • However, the varieties of Western White, Peruvian Sweet, Empire Sweet, Mexico, Texas 1015, Imperial Valley Sweet, and Vidalia demonstrated weak antiproliferative activity against both HepG(2) and Caco-2 cells [16].
  • Studies have been devoted to: the Hippocratic Corpus, to authors of the Roman Empire, to Byzantine medicine; the transmission of ancient texts through Arabic and other languages of the Middle East; the influence of Constantinus Africanus' translations from Arabic to Latin; early modern theories about semen, male sexuality, impotence [17].

Associations of DC 703 with other chemical compounds

  • I examine the development of privately provided insurance since World War II, giving special attention to Empire Blue Cross, and argue that the competition between employers and unions for the loyalty of workers after the passage of the Taft-Hartley Act helped diffuse private health insurance benefits already favored by federal policies [18].
  • Tannin concentration and protein N content of silage were lower in Empire than in the other cultivars [19].
  • The average D52 value in a model Empire apple juice was 18 min with a z value of 4.8 degrees C. Increasing the Brix from 11.8 to 16.5 degrees had no effect on thermal resistance, while increasing L-malic acid from 0.2 to 0.8%, or reducing the pH from 4.4 to 3.6 sensitized the cells to heat [20].
  • Shallots exhibited the highest total antioxidant activity (45.5 +/- 2.1 micromol of vitamin C equiv/g of onion), followed by Western Yellow, New York Bold, Northern Red, Mexico, Empire Sweet, Western White, Peruvian Sweet, Texas 1015, Imperial Valley Sweet, and Vidalia [16].
  • Modern medical education in the Ottoman Empire began with the founding of the School of Medicine and Surgery in 1827 [21].

Gene context of DC 703

  • The apple cultivars ranked in the following decreasing order: Braeburn > Red Delicious > Crisp Pink > Granny Smith > Royal Gala > Bramley > Golden Delicious > Fuji > Empire. Among pear cultivars, the order was Forelle > Taylor's > Peckham's > Conference. Peach and plum equally had high contents [22].
  • Also very significant is the fact of Freud's Jewish heritage and the anti-Semitism he experienced as a citizen of the Hapsburg Empire. Moreover, Freud was always sensitive about the power and the influence of the Catholic church [23].
  • The 'Empire State' strikes back; NYSNA launches $1 million fight against UAP [24].
  • This continued up to the time of Constantine the Great and blinding as a penalty reappeared in the Byzantine Empire (AD 705) under the rule of Justinian Rhinotmitos [25].
  • This has been so since the days of the glorious Ottoman Empire. In the year 1987, instead of investigating the roots of homosexuality, the pressing need has become to present a particular view of homosexuality in Turkey today [26].

Analytical, diagnostic and therapeutic context of DC 703


  1. Saturnine gout among Roman aristocrats. Did lead poisoning contribute to the fall of the Empire? Nriagu, J.O. N. Engl. J. Med. (1983) [Pubmed]
  2. Obesity: historical development of scientific and cultural ideas. Bray, G.A. International journal of obesity. (1990) [Pubmed]
  3. The plague under Marcus Aurelius and the decline and fall of the Roman Empire. Fears, J.R. Infect. Dis. Clin. North Am. (2004) [Pubmed]
  4. Regina Salomea Pilsztynowa, ophthalmologist in 18th-century Poland. Konczacki, J.M., Aterman, K. Survey of ophthalmology. (2002) [Pubmed]
  5. Classic pages in obstetrics and gynecology. Operation in cases of complete prolapse. Archibald Donald. Journal of Obstetrics and Gynaecology of the British Empire, vol. 13, pp. 195-196, 1908. Longo, L.D. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  6. A perspective of lead poisoning in antiquity and the present. Woolley, D.E. Neurotoxicology (1984) [Pubmed]
  7. Plantations, paternalism, and profitability: factors affecting African demography in the old British Empire. Littlefield, D.C. The Journal of southern history. (1981) [Pubmed]
  8. Growth of the anti-plague system during the Soviet period. Ben Ouagrham-Gormley, S. Crit. Rev. Microbiol. (2006) [Pubmed]
  9. Roman ophthalmology. A glimpse of our distant past. Ellerhorst, B., Cibis, G.W. Survey of ophthalmology. (1986) [Pubmed]
  10. Epidemiology of a primary pneumonic plague in Kantoshu, Manchuria, from 1910 to 1911: statistical analysis of individual records collected by the Japanese Empire. Nishiura, H. International journal of epidemiology. (2006) [Pubmed]
  11. Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication. Lee, K.W., Lee, S.J., Kang, N.J., Lee, C.Y., Lee, H.J. Biofactors (2004) [Pubmed]
  12. Cystic fibrosis carrier screening practices in an ethnically diverse region: experience of the Genetic Network of the Empire State, Puerto Rico, and the U.S. Virgin Islands. Schwind, E.L., Wolfe, M., Greendale, K., Misra, L.M., Pass, K.A., Wallerstein, R. Genet. Test. (1999) [Pubmed]
  13. The poisoning women of Tiszazug. Bodó, B. Journal of family history. (2002) [Pubmed]
  14. Chlorophyll isolation, structure and function: major landmarks of the early history of research in the Russian Empire and the Soviet Union. Krasnovsky Jr, A.A. Photosyn. Res. (2003) [Pubmed]
  15. Pediatric dermatology in antiquity Part II. Roman Empire. Radbill, S.X. International journal of dermatology. (1976) [Pubmed]
  16. Varietal differences in phenolic content and antioxidant and antiproliferative activities of onions. Yang, J., Meyers, K.J., van der Heide, J., Liu, R.H. J. Agric. Food Chem. (2004) [Pubmed]
  17. For a history of andrology. Angeletti, L.R. Medicina nei secoli. (2001) [Pubmed]
  18. Empire and the business of health insurance. Sapolsky, H.M. Journal of health politics, policy and law. (1991) [Pubmed]
  19. Effect of cultivars on in vitro and ruminal degradation of the nitrogen fraction in birdsfoot trefoil silage. Rioux, R., Dos Santos, G.T., Petit, H.V., Proulx, J.G. J. Dairy Sci. (1995) [Pubmed]
  20. Heat resistance of Escherichia coli O157:H7 in apple juice. Splittstoesser, D.F., McLellan, M.R., Churey, J.J. J. Food Prot. (1996) [Pubmed]
  21. 116 years (1889-2005) of neurosurgical practice and education at Gulhane Military Medical Academy. Timurkaynak, E., Izci, Y., Acar, F. Neurosurgery (2006) [Pubmed]
  22. Distribution of conjugated and free phenols in fruits: antioxidant activity and cultivar variations. Imeh, U., Khokhar, S. J. Agric. Food Chem. (2002) [Pubmed]
  23. Freud's ego ideals: a study of admired modern historical and political personages. Szaluta, J. Journal of the American Psychoanalytic Association. (1983) [Pubmed]
  24. The 'Empire State' strikes back; NYSNA launches $1 million fight against UAP. Waldman, B. The American nurse. (1995) [Pubmed]
  25. The penalty of blinding during Byzantine times. Medical remarks. Lascaratos, J., Marketos, S. Documenta ophthalmologica. Advances in ophthalmology. (1992) [Pubmed]
  26. Homosexuality and police terror in Turkey. Yuzgun, A. Journal of homosexuality. (1993) [Pubmed]
  27. Investigation of contemporary gilded forgeries of ancient coins. Reiff, F., Bartels, M., Gastel, M., Ortner, H.M. Fresenius' journal of analytical chemistry. (2001) [Pubmed]
  28. Explosion of renal replacement therapy after the implosion of the Soviet Empire. Rutkowski, B., Ritz, E. Ethnicity & disease. (2006) [Pubmed]
  29. Overview of the New York State program for prescription drug benefits. Lennard, E.L., Feinberg, P.E. American journal of hospital pharmacy. (1994) [Pubmed]
  30. Thermoluminescence dating of archaeological artefacts from the Middle Neolithic, Bronze Age and the Roman Empire period. Berger, T., Hajek, M., Primerano, W., Vana, N. Radiation protection dosimetry. (2002) [Pubmed]
WikiGenes - Universities