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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Birth Rate

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Disease relevance of Birth Rate


Psychiatry related information on Birth Rate


High impact information on Birth Rate

  • CONTEXT: To maximize birth rates, physicians who perform in vitro fertilization (IVF) often transfer multiple embryos, but this increases the multiple-birth risk [5].
  • GM-CSF increased the birth rate of cycling cells from 1.3 to 3.4 cells %/h and decreased the duration of the S phase from 14.3 to 9.1 h and the cell cycle time from 86 to 26 h [6].
  • Women aged 25-39 years with treated epilepsy have significantly lower fertility rates than those in the general population [7].
  • Of note, the birth rate of the CD3 eta -/- animals was significantly lower than that of wild type or heterozygous animals (P = 0.041-0.002) [8].
  • A dose-dependent decrease in birth rate was observed which correlated well with the effects on incorporation of thymidine, uridine, and leucine but not with the effect of implantation rate [9].

Biological context of Birth Rate


Anatomical context of Birth Rate


Associations of Birth Rate with chemical compounds

  • Pancreatobiliary diversion increased bromodeoxyuridine labelling index from 1.1 to 3.7% at seven days and the cell birth rate from 0.09 to 0.06% [20].
  • This report describes an epidemiologic investigation of the relationship between DBCP (dibromochloropropane) contamination in drinking water and birth rates between 1978 and 1982 in Fresno County, California. Census tracts in the county were categorized according to DBCP level in their drinking water [21].
  • Estradiol was correlated with birth rate (r = 0.160, P less than 0.001), which increased from 3.6% when E2 was less than 500 pg/mL to 19.6% when E2 was greater than or equal to 2,500 pg/mL [22].
  • Growth and fertility rates in the offspring of pregnant rats treated with L-omega nitro-L-arginine methyl ester (L-NAME), a nitric oxide inhibitor [23].
  • Although fertility rates were normal, time-to-pregnancy was delayed by treatment with 0.80 microg TCDD/kg [24].

Gene context of Birth Rate

  • The rate of cell cycle or cell birth rate was increased by 29% (P<0.05) in cells overexpressing HO-1 but decreased by 23% (P<0.05) in cells underexpressing HO-1 compared with control cells [25].
  • The beneficial effect of LIF in improving implantation and subsequent increased birth rates should be further explored [26].
  • Fertility rates were also significantly decreased in p53-/- female mice that lived to be adults, an observation not previously reported [27].
  • Furthermore, a strain of female Muc1 null mice in normal housing displays chronic infection and inflammation of the lower reproductive tract and markedly reduced fertility rates [28].
  • RESULTS: Birth rates of people who later kill themselves show disproportionate excess for April, May and June compared with the other months [29].

Analytical, diagnostic and therapeutic context of Birth Rate


  1. Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia. Goriely, A., McVean, G.A., van Pelt, A.M., O'Rourke, A.W., Wall, S.A., de Rooij, D.G., Wilkie, A.O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Pregnancy in mixed connective tissue disease: comparison with systemic lupus erythematosus. Kaufman, R.L., Kitridou, R.C. J. Rheumatol. (1982) [Pubmed]
  3. Measurement of apoptosis, proliferation and three cytokines in 46 patients with myelodysplastic syndromes. Shetty, V., Mundle, S., Alvi, S., Showel, M., Broady-Robinson, L., Dar, S., Borok, R., Showel, J., Gregory, S., Rifkin, S., Gezer, S., Parcharidou, A., Venugopal, P., Shah, R., Hernandez, B., Klein, M., Alston, D., Robin, E., Dominquez, C., Raza, A. Leuk. Res. (1996) [Pubmed]
  4. Antifertility effects of an LHRH agonist in male mice. Kher, R., Kalla, N.R. Contraception. (1996) [Pubmed]
  5. Live-birth rates and multiple-birth risk using in vitro fertilization. Schieve, L.A., Peterson, H.B., Meikle, S.F., Jeng, G., Danel, I., Burnett, N.M., Wilcox, L.S. JAMA (1999) [Pubmed]
  6. Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor. Aglietta, M., Piacibello, W., Sanavio, F., Stacchini, A., Aprá, F., Schena, M., Mossetti, C., Carnino, F., Caligaris-Cappio, F., Gavosto, F. J. Clin. Invest. (1989) [Pubmed]
  7. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Wallace, H., Shorvon, S., Tallis, R. Lancet (1998) [Pubmed]
  8. Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse. Koyasu, S., Hussey, R.E., Clayton, L.K., Lerner, A., Pedersen, R., Delany-Heiken, P., Chau, F., Reinherz, E.L. EMBO J. (1994) [Pubmed]
  9. Effects on mouse blastocysts of in vitro exposure to methylnitrosourea and 3-methylcholanthrene. Iannaccone, P.M., Tsao, T.Y., Stols, L. Cancer Res. (1982) [Pubmed]
  10. Reproduction among individuals with idiopathic/cryptogenic epilepsy: risk factors for reduced fertility in marriage. Schupf, N., Ottman, R. Epilepsia (1996) [Pubmed]
  11. Effect on birth weight of erythromycin treatment of pregnant women. McCormack, W.M., Rosner, B., Lee, Y.H., Munoz, A., Charles, D., Kass, E.H. Obstetrics and gynecology. (1987) [Pubmed]
  12. Hormonal and gestational parameters in female rats submitted to the pilocarpine model of epilepsy. Amado, D., Cavalheiro, E.A. Epilepsy Res. (1998) [Pubmed]
  13. An effective, simplified, and practical approach to intracytoplasmic sperm injection at multiple IVF centers. Schiewe, M.C. J. Assist. Reprod. Genet. (1996) [Pubmed]
  14. Epilepsy in women. Morrell, M.J. American family physician. (2002) [Pubmed]
  15. Dose effects on ewe bone remodeling of short-term sodium fluoride administration--a histomorphometric and biochemical study. Chavassieux, P., Pastoureau, P., Boivin, G., Chapuy, M.C., Delmas, P.D., Meunier, P.J. Bone (1991) [Pubmed]
  16. Adult hypolactasia, milk consumption, and age-specific fertility. Cramer, D.W., Xu, H., Sahi, T. Am. J. Epidemiol. (1994) [Pubmed]
  17. Comparison of cryoprotectants and methods of cryopreservation of fowl spermatozoa. Tselutin, K., Seigneurin, F., Blesbois, E. Poult. Sci. (1999) [Pubmed]
  18. Effects of prostaglandins on histophysiology of male reproductive organs and fertility in rats. Chinoy, N.J., Sharma, J.D., Seethalakshmi, L., Sanjeevan, A.G. Int. J. Fertil. (1980) [Pubmed]
  19. Dilauroylphosphatidylcholine liposome effects on the acrosome reaction and in vitro penetration of zona-free hamster eggs by bull sperm: II. A fertility assay for frozen-thawed semen. Graham, J.K., Foote, R.H. Gamete research. (1987) [Pubmed]
  20. Inhibitory effect of a cholecystokinin antagonist on the proliferative response of the pancreas to pancreatobiliary diversion. Watanapa, P., Efa, E.F., Beardshall, K., Calam, J., Sarraf, C.E., Alison, M.R., Williamson, R.C. Gut (1991) [Pubmed]
  21. An epidemiologic investigation of the relationship between DBCP contamination in drinking water and birth rates in Fresno County, California. Wong, O., Whorton, M.D., Gordon, N., Morgan, R.W. American journal of public health. (1988) [Pubmed]
  22. Relationship of follicle number, serum estradiol, and other factors to birth rate and multiparity in human menopausal gonadotropin-induced intrauterine insemination cycles. Dickey, R.P., Olar, T.T., Taylor, S.N., Curole, D.N., Rye, P.H., Matulich, E.M. Fertil. Steril. (1991) [Pubmed]
  23. Growth and fertility rates in the offspring of pregnant rats treated with L-omega nitro-L-arginine methyl ester (L-NAME), a nitric oxide inhibitor. Witlin, A.G., Gangula, P.R., Thompson, M.L., Yallampalli, C. Am. J. Obstet. Gynecol. (2002) [Pubmed]
  24. In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans hooded rat offspring. Gray, L.E., Wolf, C., Mann, P., Ostby, J.S. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  25. Heme oxygenase-1 attenuates glucose-mediated cell growth arrest and apoptosis in human microvessel endothelial cells. Abraham, N.G., Kushida, T., McClung, J., Weiss, M., Quan, S., Lafaro, R., Darzynkiewicz, Z., Wolin, M. Circ. Res. (2003) [Pubmed]
  26. Effect of supplementation of leukemia inhibitory factor and epidermal growth factor on murine embryonic development in vitro, implantation, and outcome of offspring. Cheung, L.P., Leung, H.Y., Bongso, A. Fertil. Steril. (2003) [Pubmed]
  27. Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction. Embree-Ku, M., Boekelheide, K. Exp. Biol. Med. (Maywood) (2002) [Pubmed]
  28. MUC1/episialin: a critical barrier in the female reproductive tract. DeSouza, M.M., Surveyor, G.A., Price, R.E., Julian, J., Kardon, R., Zhou, X., Gendler, S., Hilkens, J., Carson, D.D. J. Reprod. Immunol. (1999) [Pubmed]
  29. Effect of month of birth on the risk of suicide. Salib, E., Cortina-Borja, M. The British journal of psychiatry : the journal of mental science. (2006) [Pubmed]
  30. IVF/ICSI twin pregnancies: risks and prevention. Pinborg, A. Hum. Reprod. Update (2005) [Pubmed]
  31. Limited role for intratubal methotrexate treatment of ectopic pregnancy. Shalev, E., Peleg, D., Bustan, M., Romano, S., Tsabari, A. Fertil. Steril. (1995) [Pubmed]
  32. A new approach to methotrexate and lipiodol suspensions for ectopic pregnancy: preliminary in vitro and animal experiments. Fujishita, A., Ishimaru, T., Masuzaki, H., Matsuwaki, T., Chavez, R.O., Yamabe, T., Ogasawara, M. Journal of obstetrics and gynaecology (Tokyo, Japan) (1995) [Pubmed]
  33. Inhibitory effects of indomethacin on implantation and its related phenomena. Kanayama, K., Osada, H., Nariai, K., Endo, T. J. Int. Med. Res. (1996) [Pubmed]
  34. Effects of some beta-adrenergic blockers on male fertility parameters in rats. el-Sayed, M.G., el-Sayed, M.T., Elazab Abd el, S., Hafeiz, M.H., el-Komy, A.A., Hassan, E. DTW. Dtsch. Tierarztl. Wochenschr. (1998) [Pubmed]
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