The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL567588     2-hydroxybutanoic acid

Synonyms: NSC-6495, CHEBI:1148, AG-F-98794, HMDB00008, NSC6495, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC6495


Psychiatry related information on NSC6495

  • In this study, for determining the influence of different life style on the serum alpha hydroxybutyrate dehydrogenase activity (alpha HBD), we carried out surveys and laboratory studies on the relationships of the nutritional intake, physical activity, cigarette smoking and alcohol consumption of young females with their serum alpha HBD activity [6].

High impact information on NSC6495


Chemical compound and disease context of NSC6495


Biological context of NSC6495


Anatomical context of NSC6495


Associations of NSC6495 with other chemical compounds

  • The serum activities of creatine kinase (CPK), aldolase (ALD) and alpha-hydroxybutyrate dehydrogenase (HBD) were determined in a group of Welsh Mountain ponies before and after a 30 minute period of neuroleptanalgesia induced by i.v. injection of Immobilon and terminated by i.v. injection of Revivon [23].
  • Serum levels of Lactate Dehydrogenase (LDH), alpha-Hydroxybutyrate Dehydrogenase (HBDH) and the relative ratio of alpha-Hydroxybutyrate Dehydrogenase to Lactate Dehydrogenase (HBDH/LDH) were determined in 51 cases of histologically proved testicular germ cell tumors and 40 healthy controls [24].
  • CO2 production was significantly inhibited (30-70%) by 2-hydroxybutyric acid in cerebral cortex prisms, in total homogenates and in the mitochondrial fraction [17].
  • Plasma creatine kinase (CK), creatine kinase isoenzyme MB (CK-MB), lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (HBDH), glutamic-oxaloacetic transaminase (GOT), malondialdehyde (MDA) concentrations, and superoxide dismutase (SOD) activity were measured [25].
  • PLP concentrations were higher in the air-GLc group than in the air group. alpha-Hydroxybutyrate dehydrogenase (alpha-HBDH) and creatine kinase (CK) leakages were observed in the N2 group, whereas 1.17 +/- 0.17 mM GLc prevented leakage [26].

Gene context of NSC6495

  • Cumulative plasma release of creatine kinase (CK) and alpha-hydroxybutyrate dehydrogenase (HBD) was compared with release of alanine aminotransferase (ALT) [27].
  • METHODS: Concentrations of FABP and MYO and, for comparison, activities of the established cardiac markers, creatine kinase (CK) and alpha-hydroxybutyrate dehydrogenase (HBDH), were assayed in serial plasma samples from 138 patients with AMI [28].
  • For treatment and prognostic evaluation of patients with measles, it is important to determine the source of the increase in serum alpha-hydroxybutyrate dehydrogenase (HBD; EC [29].
  • In 87 patients with STEMI undergoing primary PCI, serial plasma concentrations of cTnI and alpha-hydroxybutyrate deshydrogenase (HBDH) were measured before PCI and over the following 72 h [30].
  • Plasma levels of H-FABP were compared with plasma activity levels of the myocardial cytoplasmic enzymes creatine kinase MB (CK-MB) and alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) [31].

Analytical, diagnostic and therapeutic context of NSC6495


  1. Prehospital thrombolysis: beneficial effects of very early treatment on infarct size and left ventricular function. Linderer, T., Schröder, R., Arntz, R., Heineking, M.L., Wunderlich, W., Kohl, K., Forycki, F., Henzgen, R., Wagner, J. J. Am. Coll. Cardiol. (1993) [Pubmed]
  2. Estimation of circulatory parameters in patients with acute myocardial infarction. Significance for calculation of enzymatic infarct size. Willems, G.M., Muijtjens, A.M., Lambi, F.H., Hermens, W.T. Cardiovasc. Res. (1979) [Pubmed]
  3. Release of alpha hydroxybutyrate from neonatal rat heart cell cultures exposed to anoxia and reoxygenation: comparison with impairment of structure and function of damaged cardiac cells. Van Der Laarse, A., Hollaar, L., Van Der Valk, L.J. Cardiovasc. Res. (1979) [Pubmed]
  4. Monitoring by alpha-hydroxybutyrate dehydrogenase of human ovarian carcinoma grown in nude mice. Kikuchi, Y., Miyauchi, M., Oomori, K., Kizawa, I., Kita, T., Seki, K., Kato, K. J. Cancer Res. Clin. Oncol. (1986) [Pubmed]
  5. The absolute configuration of urinary 2-hydroxybutyric acid in patients with ketosis and lactic acidosis. Kamerling, J.P., Gerwig, G.J., Duran, M., Ketting, D., Wadman, S.K. Clin. Chim. Acta (1978) [Pubmed]
  6. Evaluation of the effects of various factors on the serum alpha hydroxybutyrate dehydrogenase activity in young females. Imaki, M., Kawabata, K., Yoshida, Y., Nakamura, T., Tanada, S. Applied human science : journal of physiological anthropology. (1995) [Pubmed]
  7. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. Simoons, M.L., Arnold, A.E., Betriu, A., de Bono, D.P., Col, J., Dougherty, F.C., von Essen, R., Lambertz, H., Lubsen, J., Meier, B. Lancet (1988) [Pubmed]
  8. Complete recovery in plasma of enzymes lost from the heart after permanent coronary artery occlusion in the dog. Hermens, W.T., van der Veen, F.H., Willems, G.M., Mullers-Boumans, M.L., Schrijvers-van Schendel, A., Reneman, R.S. Circulation (1990) [Pubmed]
  9. Characterization of an established cell line from human immature teratoma of the ovary and effects of retinoic acid on cell proliferation. Kikuchi, Y., Momose, E., Kizawa, I., Ishida, M., Sunaga, H., Mukai, K., Seki, K., Kato, K. Cancer Res. (1984) [Pubmed]
  10. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. Zeymer, U., Suryapranata, H., Monassier, J.P., Opolski, G., Davies, J., Rasmanis, G., Linssen, G., Tebbe, U., Schröder, R., Tiemann, R., Machnig, T., Neuhaus, K.L. J. Am. Coll. Cardiol. (2001) [Pubmed]
  11. Determination of valproic acid (2-propylpentanoic acid) in human plasma by capillary electrophoresis with indirect UV detection. Pucci, V., Mandrioli, R., Raggi, M.A. Electrophoresis (2003) [Pubmed]
  12. Diagnostic performance of enzymes in the discrimination of myocardial infarction. Werner, M., Brooks, S.H., Mohrbacher, R.J., Wasserman, A.G. Clin. Chem. (1982) [Pubmed]
  13. Lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. Smith, S.J., Bos, G., Gerbrandy, J., Docter, R., Visser, T.J., Hennemann, G. Eur. J. Clin. Invest. (1978) [Pubmed]
  14. Cytoplasmic enzyme activities in human hypernephroma compared with normal renal cortical tissue. González Buitrago, J.M., Pastor, I., Corrales, J.J. Urologia internationalis. (1988) [Pubmed]
  15. Cumene hydroperoxide induced changes in calcium homeostasis in cultured neonatal rat heart cells. Persoon-Rothert, M., Egas-Kenniphaas, J.M., van der Valk-Kokshoorn, E.J., van der Laarse, A. Cardiovasc. Res. (1992) [Pubmed]
  16. Enzymatic assessment of myocardial injury after infarction or cardiac surgery. Is isoenzyme analysis required? Hermens, W.T., Willems, G.M., Davids, H.A., Hollaar, L., van der Laarse, A. Clin. Chim. Acta (1986) [Pubmed]
  17. Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain. Silva, A.R., Ruschel, C., Helegda, C., Wyse, A.T., Wannmacher, C.M., Wajner, M., Dutra-Filho, C.S. Braz. J. Med. Biol. Res. (2001) [Pubmed]
  18. Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia. Akenzua, G.I., Ihongbe, J.C., Asemota, H.N. African journal of medicine and medical sciences. (1992) [Pubmed]
  19. Effects of carbon dioxide on serum biochemical patterns and on histopathological changes of organs in rats. Mitsuda, H., Ueno, S., Mizuno, H., Ueda, T., Fujikawa, H., Nohara, T., Fukada, C. J. Nutr. Sci. Vitaminol. (1982) [Pubmed]
  20. Myocardial enzyme activities in plasma after whole-heart irradiation in rats. Franken, N.A., Strootman, E., Hollaar, L., van der Laarse, A., Wondergem, J. J. Cancer Res. Clin. Oncol. (2000) [Pubmed]
  21. Identification of 2-hydroxybutyric acid in human amniotic fluid. Nicholls, T., Hähnel, R., Wilkinson, S., Wyocki, S. Clin. Chim. Acta (1976) [Pubmed]
  22. LSH-X and HBDH/LDH ratio in human semen. Garcia Diez, L.C., Gonzalez Buitrago, J.M., Eisman, C., Meza, S., Miralles, J.M. Arch. Androl. (1982) [Pubmed]
  23. The influence of neuroleptanalgesia on the serum activity of muscle enzymes in ponies. Hillidge, C.J. Equine Vet. J. (1978) [Pubmed]
  24. Serum lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase and ratio of alpha-hydroxybutyrate dehydrogenase to lactate dehydrogenase in testicular tumours. Khanolkar, M.M., Sirsat, A.V., Deshmane, V.H., Kamat, M.R. Indian journal of cancer. (1990) [Pubmed]
  25. Effects of N-n-butyl haloperidol iodide on rat myocardial ischemia and reperfusion injury and L-type calcium current. Huang, Z.Q., Shi, G.G., Zheng, J.H., Liu, B. Acta Pharmacol. Sin. (2003) [Pubmed]
  26. The effect of 4'-deoxypyridoxine on rat heart cell cultures under oxygen deficiency. Millart, H., Freyss-Beguin, M., Van Brussel, E.M., Lechat, P. Methods and findings in experimental and clinical pharmacology. (1985) [Pubmed]
  27. Liver damage as a potential source of error in the estimation of myocardial infarct size from plasma creatine kinase activity. Oostenbroek, R.J., Willems, G.M., Boumans, M.L., Soeters, P.B., Hermens, W.T. Cardiovasc. Res. (1985) [Pubmed]
  28. Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglobin, using individually estimated clearance rates. de Groot, M.J., Wodzig, K.W., Simoons, M.L., Glatz, J.F., Hermens, W.T. Cardiovasc. Res. (1999) [Pubmed]
  29. Increased alpha-hydroxybutyrate dehydrogenase in serum from children with measles. Kano, K., Ichimura, T. Clin. Chem. (1992) [Pubmed]
  30. Troponin I concentrations following primary percutaneous coronary intervention predict large infarct size and left ventricular dysfunction in patients with ST-segment elevation acute myocardial infarction. Ohlmann, P., Monassier, J.P., Michotey, M.O., Berenger, N., Jacquemin, L., Laval, G., Roul, G., Schneider, F. Atherosclerosis (2003) [Pubmed]
  31. Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man. Kleine, A.H., Glatz, J.F., Van Nieuwenhoven, F.A., Van der Vusse, G.J. Mol. Cell. Biochem. (1992) [Pubmed]
  32. Which patients benefit most from early thrombolytic therapy with intracoronary streptokinase? Vermeer, F., Simoons, M.L., Bär, F.W., Tijssen, J.G., van Domburg, R.T., Serruys, P.W., Verheugt, F.W., Res, J.C., de Zwaan, C., van der Laarse, A. Circulation (1986) [Pubmed]
  33. Value of electrocardiographic scoring systems for the assessment of thrombolytic therapy in acute myocardial infarction. The European Cooperative Study Group for Recombinant Tissue Type Plasminogen Activator. Willems, J.L., Willems, R.J., Bijnens, I., Doerr, R., Verstraete, M. Eur. Heart J. (1991) [Pubmed]
  34. Estimation of enzymatic infarct size: direct comparison of the marker enzymes creatine kinase and alpha-hydroxybutyrate dehydrogenase. Dissmann, R., Linderer, T., Schröder, R. Am. Heart J. (1998) [Pubmed]
  35. The formation of 2-hydroxybutyric acid in experimental animals. Landaas, S. Clin. Chim. Acta (1975) [Pubmed]
  36. Clinical conditions associated with urinary excretion of 2-hydroxybutyric acid. Landaas, S., Pettersen, J.E. Scand. J. Clin. Lab. Invest. (1975) [Pubmed]
WikiGenes - Universities