Disease relevance of Methylnitrosourethane

• Concentration-dependent mutation by alkylating agents in human lymphoblasts and Salmonella typhimurium: N-methyl-N-nitrosourethane and beta-propiolactone [1].
• In 26 dogs, a single subcutaneous injection of N-nitroso-N-methylurethane produced acute lung injury characterized by tachypnea cyanosis, increased static lung recoil, and decreased lung compliance [2].
• Glycosaminoglycan and collagen synthesis in N-nitroso-N-methylurethane induced pulmonary fibrosis [3].
• Comparison of these data with previous measurements of glycosaminoglycan synthesis in another model of interstitial lung disease, induced by N-nitroso-N-methylurethane, reveals marked similarity in the changes from normal in 35S-labeling [4].
• The subcutaneous injection of 5 to 6 mg/kg of body weight of N-nitroso-N-methylurethane (NNNMU) has been reported to cause acute alveolar injury in animals [5].

High impact information on Methylnitrosourethane

• Decomposition products formed after blood plasma action on N-ethyl-N-nitrosoacetamide or N-methyl-N-nitrosoethylcarbamate were separated and identified by gas chromatography [6].
• This study evaluated the effects of varying tidal volumes (VT) and positive end-expiratory pressure (PEEP) levels on surfactant aggregate conversion and lung function in an animal model of lung injury induced by N-nitroso-N-methylurethane [7].
• On polymerase chain reaction-single strand conformation polymorphism analysis, H-ras and p53 gene mutations were observed at high and relatively low frequencies, respectively, in forestomach tumors induced by MNNG and MNUR [8].
• Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits [9].
• Male and female transgenic mice carrying the human prototype c-Ha-ras gene (rasH2 mice) and their wild littermates (non-Tg mice) received three subcutaneous injections of 0.3 mg N-methyl-N-nitrosourethane (MNUR) once every 2 weeks for the first 4 weeks followed by a single intraperitoneal injection of 1000 or 0 mg/kg urethane (UR) 2 weeks later [10].

Chemical compound and disease context of Methylnitrosourethane

• Retinoic acid was administered to hamsters suffering from N-nitroso-N-methylurethane-induced fibrosing alveolitis [11].

Biological context of Methylnitrosourethane

• DNA repair synthesis in guinea pig pancreatic slices following in vitro exposure to N-nitrosomethylurethane [12].
• Similar administration of N-nitrosomethylurethane at maximally tolerated doses did not induce such toxic effects [13].
• A study of the change in DNA synthesis of S phase cells treated with N-methyl-N-nitrosourethane: a study using Amoeba proteus as a single cell model [14].
• Comparison has been made of injury to the rat pulmonary alveolar parenchyma evoked by intravenous injection of N-nitrosomethylurethane, intratracheal instillation of 3-methylcholanthrene or repeated inhalation for up to 15 days of carbon tetrachloride, trichloroethylene or gasoline vapour [15].
• The nature of DNA damage induced by N-methyl-N-nitrosourethane (NMUT) in the guinea pig pancreas, both in vitro and in vivo, and subsequent repair was investigated by alkaline sucrose density gradient analysis, using a non-radioactive fluorimetric procedure for DNA determination in gradient fractions [16].

Anatomical context of Methylnitrosourethane

• Effects of N-methyl-N-nitrosourethane on DNA synthesis in the guinea pig pancreas [17].
• Almost all of the treated rats died with papillomas and carcinomas of the forestomach (non-glandular stomach), and the other induced tumors of significance were carcinomas and papillomas of the esophagus in rats given the 7 mg/ml dose of nitrosomethylurethane, both labeled and unlabeled [18].
• Ultrastructure and cell proliferative activities of karyomegalic alveolar epithelial cells in early pulmonary inflammatory lesions of Syrian golden hamsters induced by N-methyl-N-nitrosourethane [19].

Associations of Methylnitrosourethane with other chemical compounds

• Administration of 7.5 mg/kg body wt. of N-nitroso-N-methylurethane subcutaneously to rabbits decreased disaturated phosphatidylcholine, phosphatidylglycerol, and increased the minimum surface tension of alveolar lavage return [20].

Gene context of Methylnitrosourethane

• Pulmonary edema and death caused by N-nitroso-N-methylurethane-induced lung injury were not different in SP-A(-/-) and SP-A(+/+) mice [21].

Analytical, diagnostic and therapeutic context of Methylnitrosourethane

• Lung surfactant was isolated from bronchoalveolar lavage of dogs during the late phase of recovery (15 days) from acute alveolar injury induced by subcutaneous injection of N-nitroso-N-methylurethane [22].
• We studied the effect of positive end-expiratory pressure (PEEP) on lung compliance (CL) in 17 dogs during the early phase of acute alveolar injury induced by the subcutaneous administration of N-nitroso-N-methylurethane (NNNMU) [23].

References