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Chemical Compound Review

nuclear yellow     4-[6-[6-(4-methylpiperazin-1- yl)-1H...

Synonyms: Hoe-S769121, AC1L3XDY, AC1Q3ACV, CTK8D5336, AR-1F9778, ...
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Disease relevance of ZINC00643179

  • However, only Nuclear Yellow injections which included the intergeniculate leaflet (IGL) resulted in double-labeled ganglion cells in the retinae [1].

High impact information on ZINC00643179


Biological context of ZINC00643179


Anatomical context of ZINC00643179


Associations of ZINC00643179 with other chemical compounds


Gene context of ZINC00643179

  • Small iontophoretic or pressure injections of horseradish peroxidase (HRP), wheat-germ-HRP, Nuclear Yellow, and Fast Blue were administered to the cytoarchitectonic areas Ri (PIVC), 3aV, the parieto-temporal association area T3, the granular insula (Ig), and the rostral part of area 7 (7ant) [16].
  • Four kinds of neurons could be identified: NY-neurons with CCK-immunoreactivity (NY+CCK); FB-neurons with CCK-immunoreactivity (FB+CCK); NY+FB neurons with CCK-immunoreactivity (NY+FB+CCK); and neurons only CCK-positive [17].
  • Only two of the fluorochromes - Nuclear Yellow (Hoechst 769121) and the phenoxyindole compound D261/37 - were found to be selective for nucleic acids, while the other three fluorochromes produced small to moderate amounts of fluorescence in preparations extracted sequentially with RNase and DNase [18].
  • We found that the labeling ratio of SP/NY was 1.4%, SP/FB was 7%, and SP/NY + FB was 28.8% [19].

Analytical, diagnostic and therapeutic context of ZINC00643179

  • Suspensions of pigmented RPE cells were labeled with Nuclear Yellow prior to transplantation, and at 1 week after grafting, the transplanted RPE cells were found attached to previously denuded areas of Bruch's membrane [20].
  • Microinjections of fluorescent tracers (Nuclear Yellow and Fast Blue) were used to study the organization of olivary cells in nucleus beta which give rise to climbing fibers to the medial zone of the uvula and the intermediate zone of the pyramis [21].
  • We first labeled motoneurons with a retrograde tracer, Nuclear Yellow (NY), and then quantified the c-fos mRNA expression level in the NY-labeled alpha motoneurons by means of in situ hybridization [22].


  1. Bifurcating axons of retinal ganglion cells terminate in the hypothalamic suprachiasmatic nucleus and the intergeniculate leaflet of the thalamus. Pickard, G.E. Neurosci. Lett. (1985) [Pubmed]
  2. Injured neurons in the olfactory bulb of the adult rat grow axons along grafts of peripheral nerve. Friedman, B., Aguayo, A.J. J. Neurosci. (1985) [Pubmed]
  3. A minute fraction of Syrian golden hamster retinal ganglion cells project bilaterally. Hsiao, K., Sachs, G.M., Schneider, G.E. J. Neurosci. (1984) [Pubmed]
  4. Metabolic and morphological stability of motoneurons in response to chronically elevated neuromuscular activity. Roy, R.R., Ishihara, A., Kim, J.A., Lee, M., Fox, K., Edgerton, V.R. Neuroscience (1999) [Pubmed]
  5. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Ye, J.H., Houle, J.D. Exp. Neurol. (1997) [Pubmed]
  6. Sources of cortical, hypothalamic and spinal serotonergic projections: topical organization within the nucleus raphe dorsalis. Kazakov, V.N., Kravtsov PYa, n.u.l.l., Krakhotkina, E.D., Maisky, V.A. Neuroscience (1993) [Pubmed]
  7. Demonstration of the potential for chronically injured neurons to regenerate axons into intraspinal peripheral nerve grafts. Houle, J.D. Exp. Neurol. (1991) [Pubmed]
  8. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. McKinney, M., Coyle, J.T., Hedreen, J.C. J. Comp. Neurol. (1983) [Pubmed]
  9. Cerebellar efferents in the lizard Varanus exanthematicus. II. Projections of the cerebellar nuclei. Bangma, G.C., ten Donkelaar, H.J., Dederen, P.J., de Boer-van Huizen, R. J. Comp. Neurol. (1984) [Pubmed]
  10. The projections from the parafascicular thalamic nucleus to the subthalamic nucleus and the striatum arise from separate neuronal populations: a comparison with the corticostriatal and corticosubthalamic efferents in a retrograde fluorescent double-labelling study. Féger, J., Bevan, M., Crossman, A.R. Neuroscience (1994) [Pubmed]
  11. The subcortical afferents to caudate nucleus and putamen in primate: a fluorescence retrograde double labeling study. Parent, A., Mackey, A., De Bellefeuille, L. Neuroscience (1983) [Pubmed]
  12. Compartmental origins of the striatopallidal projection in the primate. Giménez-Amaya, J.M., Graybiel, A.M. Neuroscience (1990) [Pubmed]
  13. Associational and commissural collaterals of neurons in the hippocampal formation (hilus fasciae dentatae and subfield CA3). Laurberg, S., Sørensen, K.E. Brain Res. (1981) [Pubmed]
  14. Retrograde neuronal labeling by means of Bisbenzimide and Nuclear Yellow (Hoechst S 769121). Measures to prevent diffusion of the tracers out of retrogradely labeled neurons. Bentivoglio, M., Kuypers, H.G., Catsman-Berrevoets, C.E. Neurosci. Lett. (1980) [Pubmed]
  15. Spinal neurons which project to the periaqueductal gray and the medullary reticular formation via axon collaterals: a double-label fluorescence study in the rat. Pechura, C.M., Liu, R.P. Brain Res. (1986) [Pubmed]
  16. Cortico-cortical connections and cytoarchitectonics of the primate vestibular cortex: a study in squirrel monkeys (Saimiri sciureus). Guldin, W.O., Akbarian, S., Grüsser, O.J. J. Comp. Neurol. (1992) [Pubmed]
  17. Skin-visceral divergent projection of cholecystokinin-containing dorsal root ganglion neurons: a tri-labelling study with fluorescent tracers and immunohistochemistry. Liu, H.T., Zhu, C.G. J. Tongji Med. Univ. (1991) [Pubmed]
  18. Evaluation of five basic fluorochromes of potential use in microfluorometric studies of nucleic acids. Curtis, S.K., Cowden, R.R. Histochemistry (1983) [Pubmed]
  19. The somato-visceral divergent projections of peripheral processes of substance P-containing spinal ganglionic neurons--tri-labeling study of combining fluorescein tracing with immunocytochemistry. Liu, Q.Y., Zhu, C.G. J. Tongji Med. Univ. (1989) [Pubmed]
  20. Transplantation of retinal pigment epithelial cells to immature and adult rat hosts: short- and long-term survival characteristics. Li, L.X., Turner, J.E. Exp. Eye Res. (1988) [Pubmed]
  21. A double label retrograde tracing study of the olivocerebellar projection to the pyramis and uvula in the rat. Eisenman, L.M., Goracci, G.P. Neurosci. Lett. (1983) [Pubmed]
  22. Increased c-fos gene expression in alpha motoneurons in rat loaded hindlimb muscles with inclined locomotion. Omori, T., Kawashima, H., Kizuka, T., Ohiwa, N., Tateoka, M., Soya, H. Neurosci. Lett. (2005) [Pubmed]
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