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Chemical Compound Review

NSC-72275     2-[2-[2-(4- aminophenyl)benzothiazol-6...

Synonyms: NSC72275, LS-118808, NSC 72275, KUC103388N, AC1L9A7B, ...
 
 
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Disease relevance of Thioflavine S

 

Psychiatry related information on Thioflavine S

 

High impact information on Thioflavine S

 

Chemical compound and disease context of Thioflavine S

  • AChE infusion into rat hippocampus determines the appearance of anti-Abeta and thioflavine-S positive plaques, and AChE-Abeta toxicity on hippocampal cultures was blocked by lithium, an activator of the Wnt cascade [12].
 

Biological context of Thioflavine S

 

Anatomical context of Thioflavine S

 

Associations of Thioflavine S with other chemical compounds

 

Gene context of Thioflavine S

  • Quantification of thioflavine-S-positive Abeta deposits revealed a marked acceleration of amyloid deposition in LPS-treated APPV717F+/+-apoE+/+ mice compared to nontreated or vehicle-treated APPV717F+/+-apoE+/+ mice (P = 0.005) [21].
  • CONCLUSIONS: ApoE was immunocytochemically detected in neuritic plaques that were positive for thioflavine-S [25].
  • All of the groups contained mice with Abeta-immunoreactive deposits (56% PDAPP:E4, 20% PDAPP:E3, 75% PDAPP:E-/-), but thioflavine-S-positive Abeta (amyloid) was present only in the molecular layer of the dentate gyrus in the PDAPP:E4 mice (44%) [26].
  • ApoJ was found at the core of these deposits, and co-localized with the amyloid staining agent thioflavine-S [27].
  • In addition, CLBs and dystrophic neurites were identified immunohistochemically with antibodies specific for alpha-synuclein and ubiquitin; plaques and tangles were identified by staining with thioflavine S [28].
 

Analytical, diagnostic and therapeutic context of Thioflavine S

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