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Chemical Compound Review

NSC-72275     2-[2-[2-(4- aminophenyl)benzothiazol-6...

Synonyms: NSC72275, LS-118808, NSC 72275, KUC103388N, AC1L9A7B, ...
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Disease relevance of Thioflavine S


Psychiatry related information on Thioflavine S


High impact information on Thioflavine S


Chemical compound and disease context of Thioflavine S

  • AChE infusion into rat hippocampus determines the appearance of anti-Abeta and thioflavine-S positive plaques, and AChE-Abeta toxicity on hippocampal cultures was blocked by lithium, an activator of the Wnt cascade [12].

Biological context of Thioflavine S


Anatomical context of Thioflavine S


Associations of Thioflavine S with other chemical compounds


Gene context of Thioflavine S

  • Quantification of thioflavine-S-positive Abeta deposits revealed a marked acceleration of amyloid deposition in LPS-treated APPV717F+/+-apoE+/+ mice compared to nontreated or vehicle-treated APPV717F+/+-apoE+/+ mice (P = 0.005) [21].
  • CONCLUSIONS: ApoE was immunocytochemically detected in neuritic plaques that were positive for thioflavine-S [25].
  • All of the groups contained mice with Abeta-immunoreactive deposits (56% PDAPP:E4, 20% PDAPP:E3, 75% PDAPP:E-/-), but thioflavine-S-positive Abeta (amyloid) was present only in the molecular layer of the dentate gyrus in the PDAPP:E4 mice (44%) [26].
  • ApoJ was found at the core of these deposits, and co-localized with the amyloid staining agent thioflavine-S [27].
  • In addition, CLBs and dystrophic neurites were identified immunohistochemically with antibodies specific for alpha-synuclein and ubiquitin; plaques and tangles were identified by staining with thioflavine S [28].

Analytical, diagnostic and therapeutic context of Thioflavine S


  1. Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals. Tagliavini, F., Giaccone, G., Frangione, B., Bugiani, O. Neurosci. Lett. (1988) [Pubmed]
  2. Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Buée, L., Hof, P.R., Bouras, C., Delacourte, A., Perl, D.P., Morrison, J.H., Fillit, H.M. Acta Neuropathol. (1994) [Pubmed]
  3. Lamina-specific arrangement of astrocytic gliosis and senile plaques in Alzheimer's disease visual cortex. Beach, T.G., McGeer, E.G. Brain Res. (1988) [Pubmed]
  4. Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease. Hashimoto, M., Hsu, L.J., Sisk, A., Xia, Y., Takeda, A., Sundsmo, M., Masliah, E. Brain Res. (1998) [Pubmed]
  5. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. Forman, M.S., Lal, D., Zhang, B., Dabir, D.V., Swanson, E., Lee, V.M., Trojanowski, J.Q. J. Neurosci. (2005) [Pubmed]
  6. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. Lewis, D.A., Campbell, M.J., Terry, R.D., Morrison, J.H. J. Neurosci. (1987) [Pubmed]
  7. Human antibodies reactive with beta-amyloid protein in Alzheimer's disease. Gaskin, F., Finley, J., Fang, Q., Xu, S., Fu, S.M. J. Exp. Med. (1993) [Pubmed]
  8. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Bales, K.R., Verina, T., Cummins, D.J., Du, Y., Dodel, R.C., Saura, J., Fishman, C.E., DeLong, C.A., Piccardo, P., Petegnief, V., Ghetti, B., Paul, S.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Ginsberg, S.D., Crino, P.B., Lee, V.M., Eberwine, J.H., Trojanowski, J.Q. Ann. Neurol. (1997) [Pubmed]
  10. Butyrylcholinesterase in the life cycle of amyloid plaques. Guillozet, A.L., Smiley, J.F., Mash, D.C., Mesulam, M.M. Ann. Neurol. (1997) [Pubmed]
  11. Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy? Masliah, E., Hansen, L.A., Quijada, S., DeTeresa, R., Alford, M., Kauss, J., Terry, R. Ann. Neurol. (1991) [Pubmed]
  12. Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in Abeta neurotoxicity. Inestrosa, N.C., Alvarez, A., Godoy, J., Reyes, A., De Ferrari, G.V. Acta Neurol. Scand., Suppl. (2000) [Pubmed]
  13. Cytophotometric quantification of retrograde axonal transport of a fluorescent tracer (primuline) in mouse facial neurons. Enerbäck, L., Kristensson, K., Olsson, T. Brain Res. (1980) [Pubmed]
  14. Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods. Yao, T.M., Tomoo, K., Ishida, T., Hasegawa, H., Sasaki, M., Taniguchi, T. J. Biochem. (2003) [Pubmed]
  15. The hypothalamic lateral tuberal nucleus in Alzheimer's disease. Kremer, B., Swaab, D., Bots, G., Fisser, B., Ravid, R., Roos, R. Ann. Neurol. (1991) [Pubmed]
  16. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. Manning-Bog, A.B., McCormack, A.L., Li, J., Uversky, V.N., Fink, A.L., Di Monte, D.A. J. Biol. Chem. (2002) [Pubmed]
  17. alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons. Rideout, H.J., Dietrich, P., Wang, Q., Dauer, W.T., Stefanis, L. J. Biol. Chem. (2004) [Pubmed]
  18. Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Casas, C., Sergeant, N., Itier, J.M., Blanchard, V., Wirths, O., van der Kolk, N., Vingtdeux, V., van de Steeg, E., Ret, G., Canton, T., Drobecq, H., Clark, A., Bonici, B., Delacourte, A., Benavides, J., Schmitz, C., Tremp, G., Bayer, T.A., Benoit, P., Pradier, L. Am. J. Pathol. (2004) [Pubmed]
  19. The distribution of neuritic plaques and acetylcholinesterase staining in the amygdala in Alzheimer's disease. Brashear, H.R., Godec, M.S., Carlsen, J. Neurology (1988) [Pubmed]
  20. Non-fibrillar beta-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer disease. Frackowiak, J., Zoltowska, A., Wisniewski, H.M. J. Neuropathol. Exp. Neurol. (1994) [Pubmed]
  21. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. Qiao, X., Cummins, D.J., Paul, S.M. Eur. J. Neurosci. (2001) [Pubmed]
  22. A method for specific transmitter identification of retrogradely labeled neurons: immunofluorescence combined with fluorescence tracing. Skirboll, L., Hökfelt, T., Norell, G., Phillipson, O., Kuypers, H.G., Bentivoglio, M., Catsman-Berrevoets, C.E., Visser, T.J., Steinbusch, H., Verhofstad, A. Brain Res. (1984) [Pubmed]
  23. Evidence that epinephrine acutely redistributes blood flow to experimental intrahepatic tumors. Ackerman, N.B., Jacobs, R., Kroop, E.N., Bloom, N.D. Surgery (1989) [Pubmed]
  24. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain. Larry Sparks, D. J. Mol. Neurosci. (2004) [Pubmed]
  25. Elevated A beta and apolipoprotein E in A betaPP transgenic mice and its relationship to amyloid accumulation in Alzheimer's disease. Kuo, Y.M., Crawford, F., Mullan, M., Kokjohn, T.A., Emmerling, M.R., Weller, R.O., Roher, A.E. Mol. Med. (2000) [Pubmed]
  26. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. Hartman, R.E., Laurer, H., Longhi, L., Bales, K.R., Paul, S.M., McIntosh, T.K., Holtzman, D.M. J. Neurosci. (2002) [Pubmed]
  27. Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Martin-Rehrmann, M.D., Hoe, H.S., Capuani, E.M., Rebeck, G.W. Neurotoxicity research. (2005) [Pubmed]
  28. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Hurtig, H.I., Trojanowski, J.Q., Galvin, J., Ewbank, D., Schmidt, M.L., Lee, V.M., Clark, C.M., Glosser, G., Stern, M.B., Gollomp, S.M., Arnold, S.E. Neurology (2000) [Pubmed]
  29. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. Ostrerova-Golts, N., Petrucelli, L., Hardy, J., Lee, J.M., Farer, M., Wolozin, B. J. Neurosci. (2000) [Pubmed]
  30. Aggregation state-dependent activation of the classical complement pathway by the amyloid beta peptide. Webster, S., Bradt, B., Rogers, J., Cooper, N. J. Neurochem. (1997) [Pubmed]
  31. Identification of medial preoptic neurons that concentrate estradiol and project to the midbrain in the rat. Fahrbach, S.E., Morrell, J.I., Pfaff, D.W. J. Comp. Neurol. (1986) [Pubmed]
  32. A simple and quantitative purification of glycosphingolipids and phospholipids by thin-layer chromatography blotting. Taki, T., Kasama, T., Handa, S., Ishikawa, D. Anal. Biochem. (1994) [Pubmed]
  33. Regional capillary perfusion in muscles with limited blood supply: effects of torbafylline. Egginton, S., Hudlicka, O. Pflugers Arch. (1992) [Pubmed]
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