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Chemical Compound Review

Betalone     (17R)-17-hydroxy-17-(2- hydroxyethanoyl)-10...

Synonyms: Betapar, Betanisona, Bitanisone, meprednisone, Deltisona B, ...
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Disease relevance of Methylprednisone


High impact information on Methylprednisone


Chemical compound and disease context of Methylprednisone


Biological context of Methylprednisone


Anatomical context of Methylprednisone

  • OBJECTIVES: The purpose of this article is to review the available literature and formulate evidence-based recommendations for the use of methylprednisone in the setting of acute spinal cord injury (SCI) [17].
  • Patients on methylprednisone and deflazacort therapy had similar thyroid alterations [18].
  • Fat body mass and serum leptin increased only in methylprednisone-treated patients (P<0.025) [14].
  • This enzyme, which has been implicated in the ability of lymphocytes to mount an immune response, was evaluated in renal allografted patients immunosuppressed by azothiprine and methylprednisone [19].
  • Beside postrenal failure the patient's pregnancy was complicated by 7 rejection episodes treated with high doses of methylprednisone (total dose 5 g) with reversible damage of the transplant function, two episodes of a urinary tract infection and increasing anemia necessitating blood transfusions [20].

Associations of Methylprednisone with other chemical compounds


Gene context of Methylprednisone

  • Northern blot analyses showed a twofold increase in NHE3 mRNA expression with MP treatment [23].
  • After renal transplantation GH secretion may be influenced by glucocorticoids as shown by the lower GH response to GHRH which improved with deflazacort and the inverse correlation between methylprednisone dose and IGF-I levels [24].
  • This study compares the effects of antioxidant NSAIDs, methylprednisone and free radical scavengers against MPO-based and NaOCl-based luminol-enhanced CL [25].
  • Changes in kidney function, growth velocity, weight to height ratio and growth hormone (GH) secretion were studied before, and 2 years after, replacement of methylprednisone (6 +/- 0.3 mg/day; mean +/- SEM) by deflazacort (9.6 +/- 0.5 mg/day) 4 years after renal transplantation in 10 patients aged 9-16 years with stable renal function [26].

Analytical, diagnostic and therapeutic context of Methylprednisone


  1. Ineffectiveness of prophylactic intrathecal methylprednisolone in myelography with aqueous media. Eldevik, O.P., Haughton, V.M., Ho, K.C., Williams, A.L., Unger, G.F., Larson, S.J. Radiology. (1978) [Pubmed]
  2. Antithymocyte globulin (ATG)-based therapy in patients with myelodysplastic syndromes. Yazji, S., Giles, F.J., Tsimberidou, A.M., Estey, E.H., Kantarjian, H.M., O'Brien, S.A., Kurzrock, R. Leukemia (2003) [Pubmed]
  3. Childhood acute immune thrombocytopenic purpura: 20 years later. Blanchette, V.S., Carcao, M. Semin. Thromb. Hemost. (2003) [Pubmed]
  4. Steroids in the hemolytic uremic syndrome. Perez, N., Spizzirri, F., Rahman, R., Suarez, A., Larrubia, C., Lasarte, P. Pediatr. Nephrol. (1998) [Pubmed]
  5. High-dose intravenous 'pulse' methylprednisone in the treatment of severe oropharyngeal pemphigus: a pilot study. Mignogna, M.D., Lo Muzio, L., Ruoppo, E., Fedele, S., Lo Russo, L., Bucci, E. J. Oral Pathol. Med. (2002) [Pubmed]
  6. Treatment of lupus-induced thrombocytopenia with recombinant human interleukin-11. Feinglass, S., Deodhar, A. Arthritis Rheum. (2001) [Pubmed]
  7. Glucocorticoid-induced inhibition of osteoblastic bone formation in ewes: a biochemical and histomorphometric study. Chavassieux, P., Pastoureau, P., Chapuy, M.C., Delmas, P.D., Meunier, P.J. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1993) [Pubmed]
  8. Heart transplantation in a patient with multiple sclerosis and mitoxantrone-induced cardiomyopathy. Nägele, H., Castel, M.A., Deutsch, O., Wagner, F.M., Reichenspurner, H. J. Heart Lung Transplant. (2004) [Pubmed]
  9. Bioavailability and nonlinear disposition of methylprednisolone and methylprednisone in the rat. Haughey, D.B., Jusko, W.J. Journal of pharmaceutical sciences. (1992) [Pubmed]
  10. Combined plasmapheresis and immunosuppression as rescue treatment of a patient with catastrophic antiphospholipid syndrome occurring despite anticoagulation: a case report. Koschmieder, S., Miesbach, W., Fauth, F., Bojunga, J., Scharrer, I., Brodt, H.R. Blood Coagul. Fibrinolysis (2003) [Pubmed]
  11. Treatment of childhood prednisone-resistant nephrotic syndrome and focal segmental glomerulosclerosis with intravenous methylprednisolone and oral alkylating agents. Griswold, W.R., Tune, B.M., Reznik, V.M., Vazquez, M., Prime, D.J., Brock, P., Mendoza, S.A. Nephron (1987) [Pubmed]
  12. Biopsy of pediatric brain stem tumors. Reigel, D.H., Scarff, T.B., Woodford, J.E. Child's brain. (1979) [Pubmed]
  13. Disseminated aspergillosis following infliximab therapy in an immunosuppressed patient with Crohn's disease and chronic hepatitis C: a case study and review of the literature. Alderson, J.W., Van Dinter, T.G., Opatowsky, M.J., Burton, E.C. MedGenMed [electronic resource] : Medscape general medicine. (2005) [Pubmed]
  14. Effect of deflazacort versus methylprednisone on growth, body composition, lipid profile, and bone mass after renal transplantation. The Deflazacort Study Group. Ferraris, J.R., Pasqualini, T., Legal, S., Sorroche, P., Galich, A.M., Pennisi, P., Domene, H., Jasper, H. Pediatr. Nephrol. (2000) [Pubmed]
  15. Dose-dependent neuroprotective effects of melatonin on experimental spinal cord injury in rats. Gül, S., Celik, S.E., Kalayci, M., Taşyürekli, M., Cokar, N., Bilge, T. Surgical neurology. (2005) [Pubmed]
  16. Effects of basic fibroblast growth factor and phenytoin on healing of abdominal wall fascia and colonic anastomoses. Günes, H.V., Demirer, S., Aydinuraz, K., Kepenekci, I., Kuterdem, E., Aribal, D. International surgery. (2006) [Pubmed]
  17. The role of steroids in acute spinal cord injury: an evidence-based analysis. Hurlbert, R.J. Spine. (2001) [Pubmed]
  18. Hypothalamic-pituitary thyroid abnormalities in children after renal transplantation. Pasqualini, T., Ferraris, J., Fainstein-Day, P., Balzaretti, M., Ramirez, J., Ruiz, S., Gutman, R. Pediatr. Nephrol. (1996) [Pubmed]
  19. Adenosine-aminohydrolase activity in the erythrocytes, lymphocytes, and plasma of healthy subjects and kidney transplant recipients. Keogh, B., Pauly, J., Tritsch, G., Mittelman, A., Murphy, G.P. Journal of surgical oncology. (1976) [Pubmed]
  20. Successful outcome of a complicated pregnancy in a renal transplant recipient taking cyclosporine A. Derfler, K., Schaller, A., Herold, C., Balcke, P., Nowotny, C., Walter, R., Kopsa, H., Endler, M., Stockenhuber, F., Kletter, K. Clin. Nephrol. (1988) [Pubmed]
  21. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Braendstrup, P., Bjerrum, O.W., Nielsen, O.J., Jensen, B.A., Clausen, N.T., Hansen, P.B., Andersen, I., Schmidt, K., Andersen, T.M., Peterslund, N.A., Birgens, H.S., Plesner, T., Pedersen, B.B., Hasselbalch, H.C. Am. J. Hematol. (2005) [Pubmed]
  22. Alternation of epirubicin and mitoxantrone in CHOP-like regimens retains efficacy and reduces overall toxicity in elderly patients with high and intermediate grade non-Hodgkin lymphomas. Milone, G., Di Raimondo, F., Gioi, F.L., Palumbo, G.A., Manenti, G.O., Pafumi, M., Giustolisi, R. Leuk. Lymphoma (2002) [Pubmed]
  23. Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium. Collins, J.F., Xu, H., Kiela, P.R., Zeng, J., Ghishan, F.K. Am. J. Physiol. (1997) [Pubmed]
  24. Growth hormone--insulin-like growth factor-I (IGF-I) axis in prepubertal children with chronic renal failure. Ferraris, J., Pasqualini, T., Gutman, R., Ramírez, J., Fainstein-Day, P. Journal of pediatric endocrinology & metabolism : JPEM. (1997) [Pubmed]
  25. Comparison of the effects of antioxidant non-steroidal anti-inflammatory drugs against myeloperoxidase and hypochlorous acid luminol-enhanced chemiluminescence. Pekoe, G., Van Dyke, K., Mengoli, H., Peden, D., English, D. Agents Actions (1982) [Pubmed]
  26. Therapy with a new glucocorticoid: effect of deflazacort on linear growth and growth hormone secretion in renal transplantation. Ferraris, J.R., Pasqualini, T. The Journal of rheumatology. Supplement. (1993) [Pubmed]
  27. Effect of therapy with a new glucocorticoid, deflazacort, on linear growth and growth hormone secretion after renal transplantation. Ferraris, J.R., Day, P.F., Gutman, R., Granillo, E., Ramirez, J., Ruiz, S., Pasqualini, T. J. Pediatr. (1992) [Pubmed]
  28. Short-term effects of corticosteroids on trabecular bone remodeling in old ewes. Chavassieux, P., Buffet, A., Vergnaud, P., Garnero, P., Meunier, P.J. Bone (1997) [Pubmed]
  29. Immune responses in cardiac transplantation. I. Detection of activated TIa+ cells in the blood during herpes virus infections. O'Toole, C.M., Carvalho, G.S., Cranage, M.P., Large, S. Clin. Exp. Immunol. (1984) [Pubmed]
  30. Late manifestation of diabetes insipidus in "pure" cutaneous Langerhans cell histiocytosis. Hoeger, P.H., Janka-Schaub, G., Mensing, H. Eur. J. Pediatr. (1997) [Pubmed]
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