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Chemical Compound Review

CHEMBL137283     2,4-dichloro-1-(2,4- dichlorophenyl)benzene

Synonyms: SureCN464507, PCB 47, AG-E-72405, CHEBI:34204, KB-67079, ...
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Disease relevance of PCB 47


Psychiatry related information on PCB 47


High impact information on PCB 47


Chemical compound and disease context of PCB 47


Biological context of PCB 47


Anatomical context of PCB 47

  • Testis weight was increased 22 and 13% in rats that received the 1.6 and 3.2 mg/day Aroclor 1242 doses, respectively, while the 0.4 mg/day dose did not produce significant increases [19].
  • Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2 [20].
  • PMNs elicited with glycogen from rat peritoneum were labeled with myo-[2-3H]inositol, and the effect of fMLP and Aroclor 1242 on accumulation of [3H]inositol phosphates was determined [16].
  • To determine the physiochemical behavior of xenobiotic hydrocarbons in simulated intestinal content, we examined the partition of 7,12-dimethylbenzanthracene (DMBA), 3-methyl cholanthrene (MC), benzo(a)pyrene, and a polychlorinated biphenyl compound (PCB, Aroclor 1242) between an emulsified oil phase and a mixed micellar solution [21].
  • PCB 47 accumulated preferentially in adipose tissues (subcutaneous fat > mesenteric fat); relatively high levels of PCB 47 were also found in adrenals, ovaries, lungs, liver, and skin [22].

Associations of PCB 47 with other chemical compounds


Gene context of PCB 47

  • COX-2 mRNA was significantly elevated in response to 2,2',4,4'-tetrachlorobiphenyl in a concentration-dependent manner [20].
  • COX-2 protein and activity were also increased after exposure to 2,2',4,4'-tetrachlorobiphenyl; COX-1 protein and activity were unaffected [20].
  • These results suggest that tyrosine kinases, PKC, and the MEK/MAPK pathway are involved in a fraction of Aroclor 1242-induced activation of PLA(2) [18].
  • Both growth and pituitary GH content were increased (P < 0.05) by 3,3',5,5'-TCB (low dose) or Aroclor 1242 treatment [11].
  • Fatty acids, lipids, and cytochrome p-450 monooxygenase in hepatic microsomes of minks fed fish-based diets and exposed to Aroclor 1242 [27].

Analytical, diagnostic and therapeutic context of PCB 47


  1. Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria. De Matteis, F., Harvey, C., Reed, C., Hempenius, R. Biochem. J. (1988) [Pubmed]
  2. Genetic exchange in soil between introduced chlorobenzoate degraders and indigenous biphenyl degraders. Focht, D.D., Searles, D.B., Koh, S.C. Appl. Environ. Microbiol. (1996) [Pubmed]
  3. Degradation of aroclor 1242 dechlorination products in sediments by Burkholderia xenovorans LB400(ohb) and Rhodococcus sp. strain RHA1(fcb). Rodrigues, J.L., Kachel, C.A., Aiello, M.R., Quensen, J.F., Maltseva, O.V., Tsoi, T.V., Tiedje, J.M. Appl. Environ. Microbiol. (2006) [Pubmed]
  4. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. Bae, J., Peters-Golden, M., Loch-Caruso, R. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  5. Acutely administered polychlorinated biphenyls (PCBs) decrease splenic cellularity but increase its ability to cause graft-versus-host reactions in BALB/c mice. Carter, J.W., Clancy, J. Immunopharmacology (1980) [Pubmed]
  6. Effects of the polychlorinated biphenyl Aroclor 1242 on locomotor activity and on the neurotransmitters dopamine and norepinephrine in the brain of the gulf killifish, Fundulus grandis. Fingerman, S.W., Russell, L.C. Bulletin of environmental contamination and toxicology. (1980) [Pubmed]
  7. Distinct phospholipases A2 regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. Tithof, P.K., Peters-Golden, M., Ganey, P.E. J. Immunol. (1998) [Pubmed]
  8. Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity. Narayanan, P.K., Carter, W.O., Ganey, P.E., Roth, R.A., Voytik-Harbin, S.L., Robinson, J.P. J. Leukoc. Biol. (1998) [Pubmed]
  9. Inhibition of growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin in 5L rat hepatoma cells is associated with the presence of Ah receptor. Göttlicher, M., Cikryt, P., Wiebel, F.J. Carcinogenesis (1990) [Pubmed]
  10. Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Bae, J., Mousa, M.A., Quensen, J.F., Boyd, S.A., Loch-Caruso, R. Environ. Health Perspect. (2001) [Pubmed]
  11. Effects of polychlorinated biphenyl mixtures and three specific congeners on growth and circulating growth-related hormones. Gould, J.C., Cooper, K.R., Scanes, C.G. Gen. Comp. Endocrinol. (1997) [Pubmed]
  12. Environmental chemical-induced immune dysfunction. Loose, L.D., Pittman, K.A., Benitz, K.F., Silkworth, J.B., Mueller, W., Coulston, F. Ecotoxicol. Environ. Saf. (1978) [Pubmed]
  13. PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Khan, I.A., Thomas, P. Mar. Environ. Res. (2006) [Pubmed]
  14. Biotransformations of Aroclor 1242 in Hudson River test tube microcosms. Fish, K.M., Principe, J.M. Appl. Environ. Microbiol. (1994) [Pubmed]
  15. Behavioral effects following single and combined maternal exposure to PCB 77 (3,4,3',4'-tetrachlorobiphenyl) and PCB 47 (2,4,2',4'-tetrachlorobiphenyl) in rats. Hany, J., Lilienthal, H., Roth-Härer, A., Ostendorp, G., Heinzow, B., Winneke, G. Neurotoxicology and teratology. (1999) [Pubmed]
  16. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Tithof, P.K., Contreras, M.L., Ganey, P.E. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  17. The polychlorinated biphenyl mixture aroclor 1254 induces death of rat cerebellar granule cells: the involvement of the N-methyl-D-aspartate receptor and reactive oxygen species. Mariussen, E., Myhre, O., Reistad, T., Fonnum, F. Toxicol. Appl. Pharmacol. (2002) [Pubmed]
  18. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242. Olivero, J., Ganey, P.E. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  19. Neonatal polychlorinated biphenyl treatment increases adult testis size and sperm production in the rat. Cooke, P.S., Zhao, Y.D., Hansen, L.G. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  20. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Bezdecny, S.A., Roth, R.A., Ganey, P.E. Toxicol. Sci. (2005) [Pubmed]
  21. Polycyclic hydrocarbon and polychlorinated biphenyl solubilization in aqueous solutions of mixed micelles. Laher, J.M., Barrowman, J.A. Lipids (1983) [Pubmed]
  22. Short-term distribution, metabolism, and excretion of 2,2',5-tri-, 2, 2',4,4'-tetra-, and 3,3',4,4'-tetrachlorobiphenyls in prepubertal rats. Saghir, S.A., Koritz, G.D., Hansen, L.G. Arch. Environ. Contam. Toxicol. (1999) [Pubmed]
  23. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Tithof, P.K., Schiamberg, E., Peters-Golden, M., Ganey, P.E. Environ. Health Perspect. (1996) [Pubmed]
  24. Protein tyrosine kinase involvement in the production of superoxide anion by neutrophils exposed to Aroclor 1242, a mixture of polychlorinated biphenyls. Tithof, P.K., Watts, S., Ganey, P.E. Biochem. Pharmacol. (1997) [Pubmed]
  25. Participation of Ca2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls. Olivero, J., Ganey, P.E. Biochem. Pharmacol. (2001) [Pubmed]
  26. Comparison of gas chromatography and mineralization experiments for measuring loss of selected polychlorinated biphenyl congeners in cultures of white rot fungi. Beaudette, L.A., Davies, S., Fedorak, P.M., Ward, O.P., Pickard, M.A. Appl. Environ. Microbiol. (1998) [Pubmed]
  27. Fatty acids, lipids, and cytochrome p-450 monooxygenase in hepatic microsomes of minks fed fish-based diets and exposed to Aroclor 1242. Käkelä, R., Kinnunen, S., Käkelä, A., Hyvärinen, H., Asikainen, J. J. Toxicol. Environ. Health Part A (2001) [Pubmed]
  28. Degradation of aroclor 1242 in a single-stage coupled anaerobic/aerobic bioreactor. Tartakovsky, B., Michott, A., Cadieux, J.C., Hawari, J., Guiot, S.R. Water Res. (2001) [Pubmed]
  29. Chronic toxicity and bioaccumulation of 2,5,2',5'- and 3,4,3',4'-tetrachlorobiphenyl and Aroclor 1242 in the amphipod Hyalella azteca. Borgmann, U., Norwood, W.P., Ralph, K.M. Arch. Environ. Contam. Toxicol. (1990) [Pubmed]
  30. Evaluation of acute bioassays for assessing toxicity of polychlorinated biphenyl-contaminated soils. Hose, J.E., Barlow, L.A., Bent, S., Elseewi, A.A., Cliath, M., Resketo, M., Doyle, C. Regulatory toxicology and pharmacology : RTP. (1986) [Pubmed]
  31. Toxicity of certain polychlorinated and polybrominated biphenyls on reproductive efficiency of caged chickens. Lillie, R.J., Cecil, H.C., Bitman, J., Fries, G.F., Verrett, J. Poult. Sci. (1975) [Pubmed]
  32. Effects of polychlorinated biphenyls on thyroid hormones and liver type I monodeiodinase in the chick embryo. Gould, J.C., Cooper, K.R., Scanes, C.G. Ecotoxicol. Environ. Saf. (1999) [Pubmed]
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