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Chemical Compound Review

PulmoLAR     (8S,9S,13S,14S,17S)-2- methoxy-13-methyl-6...

Synonyms: Panzem, SureCN8796, Panzem NCD, S1233_Selleck, CHEMBL299613, ...
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Disease relevance of Panzem


High impact information on Panzem


Chemical compound and disease context of Panzem


Biological context of Panzem


Anatomical context of Panzem


Associations of Panzem with other chemical compounds


Gene context of Panzem


Analytical, diagnostic and therapeutic context of Panzem


  1. 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. Chauhan, D., Catley, L., Hideshima, T., Li, G., Leblanc, R., Gupta, D., Sattler, M., Richardson, P., Schlossman, R.L., Podar, K., Weller, E., Munshi, N., Anderson, K.C. Blood (2002) [Pubmed]
  2. Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer. Han, G.Z., Liu, Z.J., Shimoi, K., Zhu, B.T. Cancer Res. (2005) [Pubmed]
  3. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Kang, S.H., Cho, H.T., Devi, S., Zhang, Z., Escuin, D., Liang, Z., Mao, H., Brat, D.J., Olson, J.J., Simons, J.W., Lavallee, T.M., Giannakakou, P., Van Meir, E.G., Shim, H. Cancer Res. (2006) [Pubmed]
  4. Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family. Basu, A., Castle, V.P., Bouziane, M., Bhalla, K., Haldar, S. Cancer Res. (2006) [Pubmed]
  5. Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Zhou, Y., Hileman, E.O., Plunkett, W., Keating, M.J., Huang, P. Blood (2003) [Pubmed]
  6. Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. Chauhan, D., Li, G., Auclair, D., Hideshima, T., Richardson, P., Podar, K., Mitsiades, N., Mitsiades, C., Li, C., Kim, R.S., Munshi, N., Chen, L.B., Wong, W., Anderson, K.C. Blood (2003) [Pubmed]
  7. 2-methoxyestradiol alters cell motility, migration, and adhesion. Sattler, M., Quinnan, L.R., Pride, Y.B., Gramlich, J.L., Chu, S.C., Even, G.C., Kraeft, S.K., Chen, L.B., Salgia, R. Blood (2003) [Pubmed]
  8. 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells. Bhati, R., Gökmen-Polar, Y., Sledge, G.W., Fan, C., Nakshatri, H., Ketelsen, D., Borchers, C.H., Dial, M.J., Patterson, C., Klauber-DeMore, N. Cancer Res. (2007) [Pubmed]
  9. Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause. Liu, Z.J., Lee, W.J., Zhu, B.T. Cancer Res. (2005) [Pubmed]
  10. Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells. Chauhan, D., Li, G., Sattler, M., Podar, K., Mitsiades, C., Mitsiades, N., Munshi, N., Hideshima, T., Anderson, K.C. Oncogene (2003) [Pubmed]
  11. Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Kachadourian, R., Day, B.J. Free Radic. Biol. Med. (2006) [Pubmed]
  12. Ovarian cancer risk and polymorphisms involved in estrogen catabolism. Holt, S.K., Rossing, M.A., Malone, K.E., Schwartz, S.M., Weiss, N.S., Chen, C. Cancer Epidemiol. Biomarkers Prev. (2007) [Pubmed]
  13. 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. LaVallee, T.M., Zhan, X.H., Herbstritt, C.J., Kough, E.C., Green, S.J., Pribluda, V.S. Cancer Res. (2002) [Pubmed]
  14. Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. Karbowski, M., Spodnik, J.H., Teranishi, M., Wozniak, M., Nishizawa, Y., Usukura, J., Wakabayashi, T. J. Cell. Sci. (2001) [Pubmed]
  15. A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Sweeney, C., Liu, G., Yiannoutsos, C., Kolesar, J., Horvath, D., Staab, M.J., Fife, K., Armstrong, V., Treston, A., Sidor, C., Wilding, G. Clin. Cancer Res. (2005) [Pubmed]
  16. beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells. Gökmen-Polar, Y., Escuin, D., Walls, C.D., Soule, S.E., Wang, Y., Sanders, K.L., Lavallee, T.M., Wang, M., Guenther, B.D., Giannakakou, P., Sledge, G.W. Cancer Res. (2005) [Pubmed]
  17. Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Josefsson, E., Tarkowski, A. Arthritis Rheum. (1997) [Pubmed]
  18. 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. Qanungo, S., Basu, A., Das, M., Haldar, S. Oncogene (2002) [Pubmed]
  19. Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta. Nishigaki, I., Sasaguri, Y., Yagi, K. Atherosclerosis (1995) [Pubmed]
  20. Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast. Dubey, R.K., Jackson, E.K., Gillespie, D.G., Rosselli, M., Barchiesi, F., Krust, A., Keller, H., Zacharia, L.C., Imthurn, B. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  21. Testosterone-estradiol binding globulin binds to 2-methoxyestradiol with greater affinity than to testosterone. Dunn, J.F., Merriam, G.R., Eil, C., Kono, S., Loriaux, D.L., Nisula, B.C. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  22. Sex hormone-binding globulin mediates prostate androgen receptor action via a novel signaling pathway. Ding, V.D., Moller, D.E., Feeney, W.P., Didolkar, V., Nakhla, A.M., Rhodes, L., Rosner, W., Smith, R.G. Endocrinology (1998) [Pubmed]
  23. Inhibition of the soluble form of testis adenylate cyclase by catechol estrogens and other catechols. Braun, T. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  24. Metabolism of [3H]2-hydroxyestradiol by cultured porcine granulosa cells: evidence for the presence of a catechol-O-methyltransferase pathway and a direct stimulatory effect of 2-methoxyestradiol on progesterone production. Spicer, L.J., Walega, M.A., Hammond, J.M. Biol. Reprod. (1987) [Pubmed]
  25. The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. Sweeney, C.J., Miller, K.D., Sissons, S.E., Nozaki, S., Heilman, D.K., Shen, J., Sledge, G.W. Cancer Res. (2001) [Pubmed]
  26. SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells. Spink, B.C., Katz, B.H., Hussain, M.M., Pang, S., Connor, S.P., Aldous, K.M., Gierthy, J.F., Spink, D.C. Carcinogenesis (2000) [Pubmed]
  27. Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Shimada, K., Nakamura, M., Ishida, E., Kishi, M., Konishi, N. Carcinogenesis (2003) [Pubmed]
  28. 2-Methoxyestradiol exhibits a biphasic effect on VEGF-A in tumor cells and upregulation is mediated through ER-alpha: a possible signaling pathway associated with the impact of 2-ME2 on proliferative cells. Banerjee, S.N., Sengupta, K., Banerjee, S., Saxena, N.K., Banerjee, S.K. Neoplasia (2003) [Pubmed]
  29. 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. LaVallee, T.M., Zhan, X.H., Johnson, M.S., Herbstritt, C.J., Swartz, G., Williams, M.S., Hembrough, W.A., Green, S.J., Pribluda, V.S. Cancer Res. (2003) [Pubmed]
  30. Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. Golab, J., Nowis, D., Skrzycki, M., Czeczot, H., Baranczyk-Kuzma, A., Wilczynski, G.M., Makowski, M., Mroz, P., Kozar, K., Kaminski, R., Jalili, A., Kopec', M., Grzela, T., Jakobisiak, M. J. Biol. Chem. (2003) [Pubmed]
  31. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site. Cushman, M., He, H.M., Katzenellenbogen, J.A., Lin, C.M., Hamel, E. J. Med. Chem. (1995) [Pubmed]
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